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Article: Oseltamivir resistance during treatment of influenza A (H5N1) infection

TitleOseltamivir resistance during treatment of influenza A (H5N1) infection
Authors
KeywordsMedical sciences
Issue Date2005
PublisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/
Citation
New England Journal Of Medicine, 2005, v. 353 n. 25, p. 2667-2672 How to Cite?
AbstractInfluenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents. Copyright © 2005 Massachusetts Medical Society.
Persistent Identifierhttp://hdl.handle.net/10722/45199
ISSN
2015 Impact Factor: 59.558
2015 SCImago Journal Rankings: 14.619
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDe Jong, MDen_HK
dc.contributor.authorThanh, TTen_HK
dc.contributor.authorKhanh, THen_HK
dc.contributor.authorHien, VMen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorChau, NVen_HK
dc.contributor.authorVan Cam, Ben_HK
dc.contributor.authorQui, PTen_HK
dc.contributor.authorHa, DQen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorHien, TTen_HK
dc.contributor.authorFarrar, Jen_HK
dc.date.accessioned2007-10-30T06:19:36Z-
dc.date.available2007-10-30T06:19:36Z-
dc.date.issued2005en_HK
dc.identifier.citationNew England Journal Of Medicine, 2005, v. 353 n. 25, p. 2667-2672en_HK
dc.identifier.issn0028-4793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45199-
dc.description.abstractInfluenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents. Copyright © 2005 Massachusetts Medical Society.en_HK
dc.format.extent755226 bytes-
dc.format.extent2713 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/en_HK
dc.relation.ispartofNew England Journal of Medicineen_HK
dc.rightsNew England Journal of Medicine. Copyright © Massachusetts Medical Society.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciencesen_HK
dc.subject.meshAcetamides - therapeutic useen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAmino Acid Substitutionen_HK
dc.subject.meshAntiviral Agents - therapeutic useen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshChilden_HK
dc.subject.meshDrug Resistance, Viralen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics - isolation & purificationen_HK
dc.subject.meshInfluenza, Human - drug therapy - virologyen_HK
dc.subject.meshLung - radiographyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeuraminidase - antagonists & inhibitors - geneticsen_HK
dc.subject.meshOseltamiviren_HK
dc.subject.meshPneumonia, Viral - radiography - virologyen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.subject.meshViral Loaden_HK
dc.titleOseltamivir resistance during treatment of influenza A (H5N1) infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-4793&volume=353&issue=25&spage=2667&epage=2672&date=2005&atitle=Oseltamivir+Resistance+during+Treatment+of+Influenza+A+(H5N1)+Infectionen_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1056/NEJMoa054512en_HK
dc.identifier.pmid16371632en_HK
dc.identifier.scopuseid_2-s2.0-29144528757en_HK
dc.identifier.hkuros124271-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29144528757&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume353en_HK
dc.identifier.issue25en_HK
dc.identifier.spage2667en_HK
dc.identifier.epage2672en_HK
dc.identifier.isiWOS:000234094400007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10005014-
dc.identifier.scopusauthoridDe Jong, MD=7201366838en_HK
dc.identifier.scopusauthoridThanh, TT=7004531564en_HK
dc.identifier.scopusauthoridKhanh, TH=10041123400en_HK
dc.identifier.scopusauthoridHien, VM=10043209900en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridChau, NV=7102121470en_HK
dc.identifier.scopusauthoridVan Cam, B=16640670000en_HK
dc.identifier.scopusauthoridQui, PT=10042125000en_HK
dc.identifier.scopusauthoridHa, DQ=7101767746en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridHien, TT=7005271267en_HK
dc.identifier.scopusauthoridFarrar, J=7103292979en_HK
dc.identifier.citeulike464583-

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