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Article: Helicobacter pylori and associated duodenal ulcer

TitleHelicobacter pylori and associated duodenal ulcer
Authors
Issue Date1990
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 1990, v. 65 n. 11, p. 1212-1216 How to Cite?
AbstractTwenty three children with coexistent duodenal ulcer and Helicobacter pylori infection were treated with either two weeks of amoxycillin (25 mg/kg/day) in addition to six weeks of cimetidine, or cimetidine alone. Endoscopy with antral and duodenal biopsies for urease test, microaerophilic culture, and histological studies were performed at entry, six weeks, 12 weeks, and at six months. Children with persistent H pylori infection at six weeks were given a further two weeks' course of amoxycillin. H pylori persisted in all children not receiving amoxycillin treatment but cleared in six of the 13 children (46%) treated with amoxycillin. With failure of H pylori clearance at six months, only two out of six (33%) ulcers had healed and 50% of patients had experienced ulcer recurrence. In contrast, when H pylori remained cleared all ulcers healed and no ulcer recurred. Persistent H pylori infection was associated with persistent gastritis and duodenitis despite endoscopic evidence of ulcer healing. Detection and eradication of H pylori deserves particular attention in the routine management of duodenal ulceration in children.
Persistent Identifierhttp://hdl.handle.net/10722/45184
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYeung, CKen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorTsang, TMen_HK
dc.contributor.authorBranicki, FJen_HK
dc.contributor.authorSaing, Hen_HK
dc.date.accessioned2007-10-30T06:19:17Z-
dc.date.available2007-10-30T06:19:17Z-
dc.date.issued1990en_HK
dc.identifier.citationArchives Of Disease In Childhood, 1990, v. 65 n. 11, p. 1212-1216en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45184-
dc.description.abstractTwenty three children with coexistent duodenal ulcer and Helicobacter pylori infection were treated with either two weeks of amoxycillin (25 mg/kg/day) in addition to six weeks of cimetidine, or cimetidine alone. Endoscopy with antral and duodenal biopsies for urease test, microaerophilic culture, and histological studies were performed at entry, six weeks, 12 weeks, and at six months. Children with persistent H pylori infection at six weeks were given a further two weeks' course of amoxycillin. H pylori persisted in all children not receiving amoxycillin treatment but cleared in six of the 13 children (46%) treated with amoxycillin. With failure of H pylori clearance at six months, only two out of six (33%) ulcers had healed and 50% of patients had experienced ulcer recurrence. In contrast, when H pylori remained cleared all ulcers healed and no ulcer recurred. Persistent H pylori infection was associated with persistent gastritis and duodenitis despite endoscopic evidence of ulcer healing. Detection and eradication of H pylori deserves particular attention in the routine management of duodenal ulceration in children.en_HK
dc.format.extent755748 bytes-
dc.format.extent7189 bytes-
dc.format.extent2101 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.relation.ispartofArchives of Disease in Childhooden_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.subject.meshDuodenal-Ulcer-microbiologyen_HK
dc.subject.meshHelicobacter-Infections-complicationsen_HK
dc.subject.meshHelicobacter-pylorien_HK
dc.titleHelicobacter pylori and associated duodenal ulceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=65&issue=11&spage=1212&epage=1216&date=1990&atitle=Helicobacter+pylori+and+associated+duodenal+ulceren_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid2248531-
dc.identifier.pmcidPMC1792624-
dc.identifier.scopuseid_2-s2.0-0025092764en_HK
dc.identifier.volume65en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1212en_HK
dc.identifier.epage1216en_HK
dc.identifier.isiWOS:A1990EF09600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYeung, CK=23101255300en_HK
dc.identifier.scopusauthoridFu, KH=36902087400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridNg, WF=36787040900en_HK
dc.identifier.scopusauthoridTsang, TM=7101832390en_HK
dc.identifier.scopusauthoridBranicki, FJ=7003617514en_HK
dc.identifier.scopusauthoridSaing, H=7005715754en_HK

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