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- PMID: 9780243
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Article: Early diagnosis of primary human herpesvirus 6 infection in childhood: Serology, polymerase chain reaction, and virus load
Title | Early diagnosis of primary human herpesvirus 6 infection in childhood: Serology, polymerase chain reaction, and virus load |
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Authors | |
Issue Date | 1998 |
Publisher | Oxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org |
Citation | Journal Of Infectious Diseases, 1998, v. 178 n. 5, p. 1250-1256 How to Cite? |
Abstract | Qualitative and quantitative polymerase chain reaction (PCR) for human herpesvirus 6 (HHV-6) DNA in whole blood and plasma was correlated with serology and clinical assessment in 143 children hospitalized for undifferentiated febrile illness to evaluate options for diagnosis of primary HHV-6 infection on the acute blood specimen. PCR and serology for HHV-7 were done in parallel to define serologic cross-reactions. Using HHV-6 seroconversion as the reference standard, detection of HHV-6 DNA in whole blood in the absence of antibody in the plasma was the most reliable evidence of primary HHV-6 infection. Detection of HHV-6 DNA in plasma and a high virus load in whole blood (>3.3 log 10 copies/5 μL) had a sensitivity of 90% and 100%, respectively, in diagnosing primary HHV-6 infection. However, both were occasionally found in patients with other infections, possibly associated with HHV-6 reactivation. Maternal antibody may confound interpretation of serology in patients under 3 months of age. |
Persistent Identifier | http://hdl.handle.net/10722/45178 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chiu, SS | en_HK |
dc.contributor.author | Cheung, CY | en_HK |
dc.contributor.author | Tse, CYC | en_HK |
dc.contributor.author | Peiris, M | en_HK |
dc.date.accessioned | 2007-10-30T06:19:08Z | - |
dc.date.available | 2007-10-30T06:19:08Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Journal Of Infectious Diseases, 1998, v. 178 n. 5, p. 1250-1256 | en_HK |
dc.identifier.issn | 0022-1899 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/45178 | - |
dc.description.abstract | Qualitative and quantitative polymerase chain reaction (PCR) for human herpesvirus 6 (HHV-6) DNA in whole blood and plasma was correlated with serology and clinical assessment in 143 children hospitalized for undifferentiated febrile illness to evaluate options for diagnosis of primary HHV-6 infection on the acute blood specimen. PCR and serology for HHV-7 were done in parallel to define serologic cross-reactions. Using HHV-6 seroconversion as the reference standard, detection of HHV-6 DNA in whole blood in the absence of antibody in the plasma was the most reliable evidence of primary HHV-6 infection. Detection of HHV-6 DNA in plasma and a high virus load in whole blood (>3.3 log 10 copies/5 μL) had a sensitivity of 90% and 100%, respectively, in diagnosing primary HHV-6 infection. However, both were occasionally found in patients with other infections, possibly associated with HHV-6 reactivation. Maternal antibody may confound interpretation of serology in patients under 3 months of age. | en_HK |
dc.format.extent | 258994 bytes | - |
dc.format.extent | 2677 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org | en_HK |
dc.relation.ispartof | Journal of Infectious Diseases | en_HK |
dc.rights | Journal of Infectious Diseases. Copyright © University of Chicago Press. | en_HK |
dc.subject.mesh | Exanthema-Subitum-diagnosis | en_HK |
dc.subject.mesh | Viral-Load | en_HK |
dc.title | Early diagnosis of primary human herpesvirus 6 infection in childhood: Serology, polymerase chain reaction, and virus load | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=178&issue=5&spage=1250&epage=1256&date=1998&atitle=Early+diagnosis+of+primary+human+herpesvirus+6+infection+in+childhood:+serology,+polymerase+chain+reaction,+and+virus+load | en_HK |
dc.identifier.email | Chiu, SS: ssschiu@hku.hk | en_HK |
dc.identifier.email | Peiris, M: malik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chiu, SS=rp00421 | en_HK |
dc.identifier.authority | Peiris, M=rp00410 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1086/314432 | en_HK |
dc.identifier.pmid | 9780243 | - |
dc.identifier.scopus | eid_2-s2.0-0031755699 | en_HK |
dc.identifier.hkuros | 44816 | - |
dc.identifier.volume | 178 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 1250 | en_HK |
dc.identifier.epage | 1256 | en_HK |
dc.identifier.isi | WOS:000076989500003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chiu, SS=7202291500 | en_HK |
dc.identifier.scopusauthorid | Cheung, CY=55437572500 | en_HK |
dc.identifier.scopusauthorid | Tse, CYC=36958767800 | en_HK |
dc.identifier.scopusauthorid | Peiris, M=7005486823 | en_HK |
dc.identifier.issnl | 0022-1899 | - |