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Article: Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia
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TitleClinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia
 
AuthorsWoo, PCY2
Lau, SKP2
Tsoi, HW2
Huang, Y2
Poon, RWS2
Chu, CM4
Lee, RA3
Luk, WK1
Wong, GKM2
Wong, BHL2
Cheng, VCC2
Tang, BSF2
Wu, AKL2
Yung, RWH3
Chen, H2
Guan, Y2
Chan, KH2
Yuen, KY2
 
Issue Date2005
 
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
CitationJournal Of Infectious Diseases, 2005, v. 192 n. 11, p. 1898-1907 [How to Cite?]
DOI: http://dx.doi.org/10.1086/497151
 
AbstractBackground. Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. Methods. Prospectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1-associated pneumonia were analyzed. The pol, spike (S), and nucleocapsid (N) genes were also sequenced. Results. NPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol, S, and N genes revealed 2 genotypes of CoV-HKU1. Conclusions. CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses. © 2005 by the Infectious Diseases Society of America. All rights reserved.
 
ISSN0022-1899
2013 Impact Factor: 5.778
 
DOIhttp://dx.doi.org/10.1086/497151
 
ISI Accession Number IDWOS:000233018200007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWoo, PCY
 
dc.contributor.authorLau, SKP
 
dc.contributor.authorTsoi, HW
 
dc.contributor.authorHuang, Y
 
dc.contributor.authorPoon, RWS
 
dc.contributor.authorChu, CM
 
dc.contributor.authorLee, RA
 
dc.contributor.authorLuk, WK
 
dc.contributor.authorWong, GKM
 
dc.contributor.authorWong, BHL
 
dc.contributor.authorCheng, VCC
 
dc.contributor.authorTang, BSF
 
dc.contributor.authorWu, AKL
 
dc.contributor.authorYung, RWH
 
dc.contributor.authorChen, H
 
dc.contributor.authorGuan, Y
 
dc.contributor.authorChan, KH
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2007-10-30T06:19:01Z
 
dc.date.available2007-10-30T06:19:01Z
 
dc.date.issued2005
 
dc.description.abstractBackground. Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. Methods. Prospectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1-associated pneumonia were analyzed. The pol, spike (S), and nucleocapsid (N) genes were also sequenced. Results. NPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol, S, and N genes revealed 2 genotypes of CoV-HKU1. Conclusions. CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses. © 2005 by the Infectious Diseases Society of America. All rights reserved.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent650187 bytes
 
dc.format.extent1831689 bytes
 
dc.format.extent2713 bytes
 
dc.format.mimetypeapplication/pdf
 
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dc.identifier.citationJournal Of Infectious Diseases, 2005, v. 192 n. 11, p. 1898-1907 [How to Cite?]
DOI: http://dx.doi.org/10.1086/497151
 
dc.identifier.doihttp://dx.doi.org/10.1086/497151
 
dc.identifier.epage1907
 
dc.identifier.hkuros114686
 
dc.identifier.isiWOS:000233018200007
 
dc.identifier.issn0022-1899
2013 Impact Factor: 5.778
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid16267760
 
dc.identifier.scopuseid_2-s2.0-27544516178
 
dc.identifier.spage1898
 
dc.identifier.urihttp://hdl.handle.net/10722/45173
 
dc.identifier.volume192
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Infectious Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCommunity-Acquired-Infections-epidemiology
 
dc.subject.meshCommunity-Acquired-Infections-mortality
 
dc.subject.meshCommunity-Acquired-Infections-physiopathology
 
dc.subject.meshCommunity-Acquired-Infections-virology
 
dc.subject.meshCoronavirus-genetics
 
dc.titleClinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia
 
dc.typeArticle
 
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Author Affiliations
  1. Tseung Kwan O Hospital
  2. The University of Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong