Article: Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleClinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia
AuthorsWoo, PCY2
Lau, SKP2
Tsoi, HW2
Huang, Y2
Poon, RWS2
Chu, CM4
Lee, RA3
Luk, WK1
Wong, GKM2
Wong, BHL2
Cheng, VCC2
Tang, BSF2
Wu, AKL2
Yung, RWH3
Chen, H2
Guan, Y2
Chan, KH2
Yuen, KY2
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
CitationJournal Of Infectious Diseases, 2005, v. 192 n. 11, p. 1898-1907 [How to Cite?]
DOI: http://dx.doi.org/10.1086/497151
AbstractBackground. Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. Methods. Prospectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1-associated pneumonia were analyzed. The pol, spike (S), and nucleocapsid (N) genes were also sequenced. Results. NPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol, S, and N genes revealed 2 genotypes of CoV-HKU1. Conclusions. CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses. © 2005 by the Infectious Diseases Society of America. All rights reserved.
ISSN0022-1899
2011 Impact Factor: 6.41
2011 SCImago Journal Rankings: 0.831
DOIhttp://dx.doi.org/10.1086/497151
ISI Accession Number IDWOS:000233018200007
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWoo, PCY
dc.contributor.authorLau, SKP
dc.contributor.authorTsoi, HW
dc.contributor.authorHuang, Y
dc.contributor.authorPoon, RWS
dc.contributor.authorChu, CM
dc.contributor.authorLee, RA
dc.contributor.authorLuk, WK
dc.contributor.authorWong, GKM
dc.contributor.authorWong, BHL
dc.contributor.authorCheng, VCC
dc.contributor.authorTang, BSF
dc.contributor.authorWu, AKL
dc.contributor.authorYung, RWH
dc.contributor.authorChen, H
dc.contributor.authorGuan, Y
dc.contributor.authorChan, KH
dc.contributor.authorYuen, KY
dc.date.accessioned2007-10-30T06:19:01Z
dc.date.available2007-10-30T06:19:01Z
dc.date.issued2005
dc.description.abstractBackground. Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. Methods. Prospectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1-associated pneumonia were analyzed. The pol, spike (S), and nucleocapsid (N) genes were also sequenced. Results. NPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol, S, and N genes revealed 2 genotypes of CoV-HKU1. Conclusions. CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses. © 2005 by the Infectious Diseases Society of America. All rights reserved.
dc.description.naturepublished_or_final_version
dc.format.extent650187 bytes
dc.format.extent1831689 bytes
dc.format.extent2713 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.citationJournal Of Infectious Diseases, 2005, v. 192 n. 11, p. 1898-1907 [How to Cite?]
DOI: http://dx.doi.org/10.1086/497151
dc.identifier.doihttp://dx.doi.org/10.1086/497151
dc.identifier.epage1907
dc.identifier.hkuros114686
dc.identifier.isiWOS:000233018200007
dc.identifier.issn0022-1899
2011 Impact Factor: 6.41
2011 SCImago Journal Rankings: 0.831
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid16267760
dc.identifier.scopuseid_2-s2.0-27544516178
dc.identifier.spage1898
dc.identifier.urihttp://hdl.handle.net/10722/45173
dc.identifier.volume192
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Infectious Diseases
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCommunity-Acquired-Infections-epidemiology
dc.subject.meshCommunity-Acquired-Infections-mortality
dc.subject.meshCommunity-Acquired-Infections-physiopathology
dc.subject.meshCommunity-Acquired-Infections-virology
dc.subject.meshCoronavirus-genetics
dc.titleClinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia
dc.typeArticle
Author Affiliations
  1. Tseung Kwan O Hospital
  2. The University of Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong