File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses

TitleDifferential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2006, v. 194 n. 1, p. 61-70 How to Cite?
AbstractIn 1997, avian influenza virus H5N1 was transmitted directly from chicken to human and resulted in a severe disease that had a higher mortality rate in adults than in children. The characteristic mononuclear leukocyte infiltration in the lung and the high inflammatory response in H5N1 infection prompted us to compare the chemokine responses between influenza virus-infected adult and neonatal monocyte-derived macrophages (MDMs). The effects of avian influenza virus A/Hong Kong/483/97 (H5N1) (H5N1/97), its precursor A/Quail/Hong Kong/G1/97 (H9N2) (H9N2/G1), and human influenza virus A/Hong Kong/54/98 (H1N1) (H1N1/98) were compared. Significantly higher expression of CCL2, CCL3, CCL5, and CXCL10 was induced by avian influenza viruses than by human influenza virus. Moreover, the increase in CCL3 expression in H5N1/97-infected adult MDMs was significantly higher than that in neonatal MDMs. Enhanced expression of CCR1 and CCR5 was found in avian virus-infected adult MDMs. The strong induction of chemokines and their receptors by avian influenza viruses, particularly in adult MDMs, may account for the severity of H5N1 disease. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/45170
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorNg, IHYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2007-10-30T06:18:57Z-
dc.date.available2007-10-30T06:18:57Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2006, v. 194 n. 1, p. 61-70en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45170-
dc.description.abstractIn 1997, avian influenza virus H5N1 was transmitted directly from chicken to human and resulted in a severe disease that had a higher mortality rate in adults than in children. The characteristic mononuclear leukocyte infiltration in the lung and the high inflammatory response in H5N1 infection prompted us to compare the chemokine responses between influenza virus-infected adult and neonatal monocyte-derived macrophages (MDMs). The effects of avian influenza virus A/Hong Kong/483/97 (H5N1) (H5N1/97), its precursor A/Quail/Hong Kong/G1/97 (H9N2) (H9N2/G1), and human influenza virus A/Hong Kong/54/98 (H1N1) (H1N1/98) were compared. Significantly higher expression of CCL2, CCL3, CCL5, and CXCL10 was induced by avian influenza viruses than by human influenza virus. Moreover, the increase in CCL3 expression in H5N1/97-infected adult MDMs was significantly higher than that in neonatal MDMs. Enhanced expression of CCR1 and CCR5 was found in avian virus-infected adult MDMs. The strong induction of chemokines and their receptors by avian influenza viruses, particularly in adult MDMs, may account for the severity of H5N1 disease. © 2006 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.format.extent1152541 bytes-
dc.format.extent90580 bytes-
dc.format.extent2695 bytes-
dc.format.extent3264 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshChemokines-biosynthesisen_HK
dc.subject.meshInfluenza-A-Virus,-H1N1-Subtype-immunologyen_HK
dc.subject.meshInfluenza-A-Virus,-H5N1-Subtype-immunologyen_HK
dc.subject.meshInfluenza-A-Virus,-H9N2-Subtype-immunologyen_HK
dc.subject.meshMacrophages-immunologyen_HK
dc.titleDifferential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza virusesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=194&issue=1&spage=61&epage=70&date=2006&atitle=Differential+expression+of+chemokines+and+their+receptors+in+adult+and+neonatal+macrophages+infected+with+human+or+avian+influenza+virusesen_HK
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityCheung, CY=rp00404en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/504690en_HK
dc.identifier.pmid16741883-
dc.identifier.scopuseid_2-s2.0-33745216720en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745216720&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue1en_HK
dc.identifier.spage61en_HK
dc.identifier.epage70en_HK
dc.identifier.isiWOS:000238337400010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, J=34871165300en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridCheung, CY=7202061836en_HK
dc.identifier.scopusauthoridNg, IHY=8671050800en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats