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Article: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

TitleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Authors
Issue Date2006
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2006, v. 6 How to Cite?
AbstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/45169
ISSN
2014 Impact Factor: 2.613
2013 SCImago Journal Rankings: 1.420
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChong, WPen_HK
dc.contributor.authorIp, WKEen_HK
dc.contributor.authorTso, GHWen_HK
dc.contributor.authorNg, MWen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorChow, EYen_HK
dc.contributor.authorAu, KLen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2007-10-30T06:18:55Z-
dc.date.available2007-10-30T06:18:55Z-
dc.date.issued2006en_HK
dc.identifier.citationBmc Infectious Diseases, 2006, v. 6en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45169-
dc.description.abstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.en_HK
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dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshGenetic-Predisposition-to-Diseaseen_HK
dc.subject.meshInterferon-Type-II-geneticsen_HK
dc.subject.meshPolymorphism,-Single-Nucleotideen_HK
dc.subject.meshSevere-Acute-Respiratory-Syndrome-geneticsen_HK
dc.titleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=6&spage=82&epage=&date=2006&atitle=The+interferon+gamma+gene+polymorphism++874+A/T+is+associated+with+severe+acute+respiratory+syndromeen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1471-2334-6-82en_HK
dc.identifier.pmid16672072en_HK
dc.identifier.pmcidPMC1468415-
dc.identifier.scopuseid_2-s2.0-33646891057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646891057&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.isiWOS:000237978900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridIp, WKE=35083568800en_HK
dc.identifier.scopusauthoridTso, GHW=8617703000en_HK
dc.identifier.scopusauthoridNg, MW=9238285000en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK
dc.identifier.scopusauthoridChow, EY=7102595571en_HK
dc.identifier.scopusauthoridAu, KL=7006641953en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLim, W=16205075400en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike687042-

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