Article: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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TitleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
AuthorsChong, WP1
Ip, WKE1
Tso, GHW1
Ng, MW1
Wong, WHS1
Law, HKW1
Yung, RWH1
Chow, EY1
Au, KL1
Chan, EYT1
Lim, W1
Peiris, JSM1
Lau, YL1
Issue Date2006
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
CitationBmc Infectious Diseases, 2006, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-6-82
AbstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
ISSN1471-2334
2011 Impact Factor: 3.118
2011 SCImago Journal Rankings: 0.263
DOIhttp://dx.doi.org/10.1186/1471-2334-6-82
ISI Accession Number IDWOS:000237978900001
PubMed Central IDPMC1468415
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChong, WP
dc.contributor.authorIp, WKE
dc.contributor.authorTso, GHW
dc.contributor.authorNg, MW
dc.contributor.authorWong, WHS
dc.contributor.authorLaw, HKW
dc.contributor.authorYung, RWH
dc.contributor.authorChow, EY
dc.contributor.authorAu, KL
dc.contributor.authorChan, EYT
dc.contributor.authorLim, W
dc.contributor.authorPeiris, JSM
dc.contributor.authorLau, YL
dc.date.accessioned2007-10-30T06:18:55Z
dc.date.available2007-10-30T06:18:55Z
dc.date.issued2006
dc.description.abstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
dc.description.naturepublished_or_final_version
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dc.identifier.citationBmc Infectious Diseases, 2006, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-6-82
dc.identifier.citeulike687042
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-6-82
dc.identifier.isiWOS:000237978900001
dc.identifier.issn1471-2334
2011 Impact Factor: 3.118
2011 SCImago Journal Rankings: 0.263
dc.identifier.openurl
dc.identifier.pmcidPMC1468415
dc.identifier.pmid16672072
dc.identifier.scopuseid_2-s2.0-33646891057
dc.identifier.urihttp://hdl.handle.net/10722/45169
dc.identifier.volume6
dc.languageeng
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBMC Infectious Diseases
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshGenetic-Predisposition-to-Disease
dc.subject.meshInterferon-Type-II-genetics
dc.subject.meshPolymorphism,-Single-Nucleotide
dc.subject.meshSevere-Acute-Respiratory-Syndrome-genetics
dc.titleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong