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Article: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

TitleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Authors
Chong, WPIp, WKETso, GHWNg, MWWong, WHSLaw, HKWYung, RWHChow, EYAu, KLChan, EYTLim, WPeiris, JSMLau, YL
Issue Date2006
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2006, v. 6 How to Cite?
DOI: http://dx.doi.org/10.1186/1471-2334-6-82
AbstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/45169
ISSN
1471-2334
2021 Impact Factor: 3.667
2020 SCImago Journal Rankings: 1.278
PubMed Central ID
PMC1468415
ISI Accession Number ID
WOS:000237978900001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChong, WPen_HK
dc.contributor.authorIp, WKEen_HK
dc.contributor.authorTso, GHWen_HK
dc.contributor.authorNg, MWen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorChow, EYen_HK
dc.contributor.authorAu, KLen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2007-10-30T06:18:55Z-
dc.date.available2007-10-30T06:18:55Z-
dc.date.issued2006en_HK
dc.identifier.citationBmc Infectious Diseases, 2006, v. 6en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45169-
dc.description.abstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.en_HK
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dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject.meshGenetic-Predisposition-to-Diseaseen_HK
dc.subject.meshInterferon-Type-II-geneticsen_HK
dc.subject.meshPolymorphism,-Single-Nucleotideen_HK
dc.subject.meshSevere-Acute-Respiratory-Syndrome-geneticsen_HK
dc.titleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=6&spage=82&epage=&date=2006&atitle=The+interferon+gamma+gene+polymorphism++874+A/T+is+associated+with+severe+acute+respiratory+syndromeen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1471-2334-6-82en_HK
dc.identifier.pmid16672072-
dc.identifier.pmcidPMC1468415-
dc.identifier.scopuseid_2-s2.0-33646891057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646891057&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.isiWOS:000237978900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridIp, WKE=35083568800en_HK
dc.identifier.scopusauthoridTso, GHW=8617703000en_HK
dc.identifier.scopusauthoridNg, MW=9238285000en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK
dc.identifier.scopusauthoridChow, EY=7102595571en_HK
dc.identifier.scopusauthoridAu, KL=7006641953en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLim, W=16205075400en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike687042-
dc.identifier.issnl1471-2334-

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