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Article: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
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TitleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
 
AuthorsChong, WP1
Ip, WKE1
Tso, GHW1
Ng, MW1
Wong, WHS1
Law, HKW1
Yung, RWH4
Chow, EY5
Au, KL2
Chan, EYT1
Lim, W3
Peiris, JSM1
Lau, YL1
 
Issue Date2006
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
 
CitationBmc Infectious Diseases, 2006, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-6-82
 
AbstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
 
ISSN1471-2334
2013 Impact Factor: 2.561
2013 SCImago Journal Rankings: 1.420
 
DOIhttp://dx.doi.org/10.1186/1471-2334-6-82
 
PubMed Central IDPMC1468415
 
ISI Accession Number IDWOS:000237978900001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChong, WP
 
dc.contributor.authorIp, WKE
 
dc.contributor.authorTso, GHW
 
dc.contributor.authorNg, MW
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorLaw, HKW
 
dc.contributor.authorYung, RWH
 
dc.contributor.authorChow, EY
 
dc.contributor.authorAu, KL
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorLim, W
 
dc.contributor.authorPeiris, JSM
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2007-10-30T06:18:55Z
 
dc.date.available2007-10-30T06:18:55Z
 
dc.date.issued2006
 
dc.description.abstractBackground: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility. © 2006 Po Chong et al; licensee BioMed Central Ltd.
 
dc.description.naturepublished_or_final_version
 
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dc.identifier.citationBmc Infectious Diseases, 2006, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-6-82
 
dc.identifier.citeulike687042
 
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-6-82
 
dc.identifier.isiWOS:000237978900001
 
dc.identifier.issn1471-2334
2013 Impact Factor: 2.561
2013 SCImago Journal Rankings: 1.420
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1468415
 
dc.identifier.pmid16672072
 
dc.identifier.scopuseid_2-s2.0-33646891057
 
dc.identifier.urihttp://hdl.handle.net/10722/45169
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBMC Infectious Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshGenetic-Predisposition-to-Disease
 
dc.subject.meshInterferon-Type-II-genetics
 
dc.subject.meshPolymorphism,-Single-Nucleotide
 
dc.subject.meshSevere-Acute-Respiratory-Syndrome-genetics
 
dc.titleThe interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
 
dc.typeArticle
 
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<description.abstract>Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-&#947;,TNF-&#945; and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-&#947;,TNF-&#945; and IL-10 for their associations with SARS. Results: IFN- &#947;+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P &lt; 0.001). Individuals with IFN-&#947; +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-&#945; were not associated with SARS susceptibility. Conclusion: IFN-&#947;+874A allele was shown to be a risk factor in SARS susceptibility. &#169; 2006 Po Chong et al; licensee BioMed Central Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Government Virus Unit
  4. Pamela Youde Nethersole Eastern Hospital
  5. United Christian Hospital Hong Kong