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Article: Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

TitleDistribution of amantadine-resistant H5N1 avian influenza variants in Asia
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2006, v. 193 n. 12, p. 1626-1629 How to Cite?
AbstractWe examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine→isoleucine at aa 26 and serine→asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/45168
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorNaipospos, TSPen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, Hen_HK
dc.date.accessioned2007-10-30T06:18:53Z-
dc.date.available2007-10-30T06:18:53Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2006, v. 193 n. 12, p. 1626-1629en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45168-
dc.description.abstractWe examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine→isoleucine at aa 26 and serine→asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations. © 2006 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.format.extent186630 bytes-
dc.format.extent2695 bytes-
dc.format.extent7189 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAmantadine-pharmacologyen_HK
dc.subject.meshDrug-Resistance,-Viral-geneticsen_HK
dc.subject.meshInfluenza-A-Virus,-H5N1-Subtype-drug-effectsen_HK
dc.subject.meshInfluenza-A-Virus,-H5N1-Subtype-geneticsen_HK
dc.subject.meshRimantadine-pharmacologyen_HK
dc.titleDistribution of amantadine-resistant H5N1 avian influenza variants in Asiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=193&issue=12&spage=1626&epage=1629&date=2006&atitle=Distribution+of+amantadine-resistant+H5N1+avian+influenza+variants+in+Asiaen_HK
dc.identifier.emailSmith, GJD:gjsmith@hkucc.hku.hken_HK
dc.identifier.emailZhang, J:zhangajx@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM:malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y:yguan@hkucc.hku.hken_HK
dc.identifier.emailChen, H:hlchen@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/504723en_HK
dc.identifier.pmid16703504-
dc.identifier.scopuseid_2-s2.0-33744786760en_HK
dc.identifier.hkuros120653-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744786760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume193en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1626en_HK
dc.identifier.epage1629en_HK
dc.identifier.isiWOS:000237553400003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridRayner, JM=12752258200en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridNaipospos, TSP=8722763000en_HK
dc.identifier.scopusauthoridZhang, J=12752135600en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK

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