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Article: Screening for hepatocellular carcinoma (HCC): Is it cost-effective?

TitleScreening for hepatocellular carcinoma (HCC): Is it cost-effective?
Authors
KeywordsMedical sciences
Issue Date2000
PublisherHong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/
Citation
Hong Kong Practitioner, 2000, v. 22 n. 11, p. 546-551 How to Cite?
AbstractHepatocellular carcinoma (HCC) killed 1286 people in 1996 in Hong Kong. It is the second most common cancer death for men and the fourth for women. Over 90% of HCC occur after the age of 40 and 84% are in chronic hepatitis B carriers. The only cure for HCC is surgical resection when it is small. This article applies current evidence to our local epidemiological data to estimate the cost-effectiveness of different HCC screening programmes for hepatitis B carriers aged 40 to 69. The estimated number of persons needed to screen (NNT) for 30 years is 16 for men and 44 for women and the cost is HK$1.30 million for men and HK$3.56 million for women per life saved by four-monthly ultrasonography and serum alpha foetal protein (α-FP) screening. The cost per life saved is lower for the less intensive screening programmes but some potentially preventable HCC deaths may be missed. HCC screening for chronic hepatitis B carriers is more cost-effective than mammogram screening and is comparable to cervical cancer screening. Screening for HCC satisfies nearly all the principles for screening, but its effectiveness and feasibility have to be proven by further clinical trials.
Persistent Identifierhttp://hdl.handle.net/10722/45109
ISSN
2015 SCImago Journal Rankings: 0.101
References

 

DC FieldValueLanguage
dc.contributor.authorLam, CLKen_HK
dc.date.accessioned2007-10-30T06:17:36Z-
dc.date.available2007-10-30T06:17:36Z-
dc.date.issued2000en_HK
dc.identifier.citationHong Kong Practitioner, 2000, v. 22 n. 11, p. 546-551en_HK
dc.identifier.issn1027-3948en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45109-
dc.description.abstractHepatocellular carcinoma (HCC) killed 1286 people in 1996 in Hong Kong. It is the second most common cancer death for men and the fourth for women. Over 90% of HCC occur after the age of 40 and 84% are in chronic hepatitis B carriers. The only cure for HCC is surgical resection when it is small. This article applies current evidence to our local epidemiological data to estimate the cost-effectiveness of different HCC screening programmes for hepatitis B carriers aged 40 to 69. The estimated number of persons needed to screen (NNT) for 30 years is 16 for men and 44 for women and the cost is HK$1.30 million for men and HK$3.56 million for women per life saved by four-monthly ultrasonography and serum alpha foetal protein (α-FP) screening. The cost per life saved is lower for the less intensive screening programmes but some potentially preventable HCC deaths may be missed. HCC screening for chronic hepatitis B carriers is more cost-effective than mammogram screening and is comparable to cervical cancer screening. Screening for HCC satisfies nearly all the principles for screening, but its effectiveness and feasibility have to be proven by further clinical trials.en_HK
dc.format.extent340923 bytes-
dc.format.extent6261 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/en_HK
dc.relation.ispartofHong Kong Practitioneren_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciencesen_HK
dc.titleScreening for hepatocellular carcinoma (HCC): Is it cost-effective?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=22&issue=11&spage=546&epage=551&date=2000&atitle=Screening+for+hepatocellular+carcinoma+(HCC):+is+it+cost-effective?en_HK
dc.identifier.emailLam, CLK:clklam@hku.hken_HK
dc.identifier.authorityLam, CLK=rp00350en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.scopuseid_2-s2.0-0033647155en_HK
dc.identifier.hkuros60943-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033647155&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue11en_HK
dc.identifier.spage546en_HK
dc.identifier.epage551en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLam, CLK=24755913900en_HK

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