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Article: An update on myasthenia gravis

TitleAn update on myasthenia gravis
Authors
KeywordsMedical sciences
Issue Date2000
PublisherHong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/
Citation
Hong Kong Practitioner, 2000, v. 22 n. 1, p. 8-20 How to Cite?
AbstractMyasthenia gravis (MG) is an autoimmune disease characterised by autoantibodies against acetylcholine receptors at neuromuscular junctions, resulting in defective neuromuscular transmission. The characteristic features are fatigability and fluctuating weakness of skeletal muscles. It commonly presents with diplopia or unilateral ptosis, which are worse in the evenings. Respiratory muscle weakness may result in respiratory failure. MG is associated with various autoimmune diseases, and thymic hyperplasia or thymoma. An early diagnosis depends on a high index of suspicion, and is confirmed using tensilon test, and electromyography (EMG), and by a raised acetylcholine receptor antibody titre. Symptomatic treatment consists of cholinesterase inhibitors, corticosteroids and other immunosuppressants. Plasmapheresis or pooled intravenous human IgG (IVIgG) provides rapid but short-term relief for acute exacerbations. Thymectomy provides long-term control for patients with thymic hyperplasia, and is essential for thymomas.
Persistent Identifierhttp://hdl.handle.net/10722/45090
ISSN
2015 SCImago Journal Rankings: 0.101

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2007-10-30T06:17:13Z-
dc.date.available2007-10-30T06:17:13Z-
dc.date.issued2000en_HK
dc.identifier.citationHong Kong Practitioner, 2000, v. 22 n. 1, p. 8-20en_HK
dc.identifier.issn1027-3948en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45090-
dc.description.abstractMyasthenia gravis (MG) is an autoimmune disease characterised by autoantibodies against acetylcholine receptors at neuromuscular junctions, resulting in defective neuromuscular transmission. The characteristic features are fatigability and fluctuating weakness of skeletal muscles. It commonly presents with diplopia or unilateral ptosis, which are worse in the evenings. Respiratory muscle weakness may result in respiratory failure. MG is associated with various autoimmune diseases, and thymic hyperplasia or thymoma. An early diagnosis depends on a high index of suspicion, and is confirmed using tensilon test, and electromyography (EMG), and by a raised acetylcholine receptor antibody titre. Symptomatic treatment consists of cholinesterase inhibitors, corticosteroids and other immunosuppressants. Plasmapheresis or pooled intravenous human IgG (IVIgG) provides rapid but short-term relief for acute exacerbations. Thymectomy provides long-term control for patients with thymic hyperplasia, and is essential for thymomas.en_HK
dc.format.extent3059297 bytes-
dc.format.extent9894 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/en_HK
dc.relation.ispartofHong Kong Practitioneren_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciencesen_HK
dc.titleAn update on myasthenia gravisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=22&issue=1&spage=8&epage=20&date=2000&atitle=An+update+on+myasthenia+gravisen_HK
dc.identifier.emailHo, SL:slho@hku.hken_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.scopuseid_2-s2.0-0034063991en_HK
dc.identifier.hkuros49903-
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage8en_HK
dc.identifier.epage20en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK

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