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Article: An update on myasthenia gravis
Title | An update on myasthenia gravis |
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Authors | |
Keywords | Medical sciences |
Issue Date | 2000 |
Publisher | Hong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/ |
Citation | Hong Kong Practitioner, 2000, v. 22 n. 1, p. 8-20 How to Cite? |
Abstract | Myasthenia gravis (MG) is an autoimmune disease characterised by autoantibodies against acetylcholine receptors at neuromuscular junctions, resulting in defective neuromuscular transmission. The characteristic features are fatigability and fluctuating weakness of skeletal muscles. It commonly presents with diplopia or unilateral ptosis, which are worse in the evenings. Respiratory muscle weakness may result in respiratory failure. MG is associated with various autoimmune diseases, and thymic hyperplasia or thymoma. An early diagnosis depends on a high index of suspicion, and is confirmed using tensilon test, and electromyography (EMG), and by a raised acetylcholine receptor antibody titre. Symptomatic treatment consists of cholinesterase inhibitors, corticosteroids and other immunosuppressants. Plasmapheresis or pooled intravenous human IgG (IVIgG) provides rapid but short-term relief for acute exacerbations. Thymectomy provides long-term control for patients with thymic hyperplasia, and is essential for thymomas. |
Persistent Identifier | http://hdl.handle.net/10722/45090 |
ISSN | 2023 SCImago Journal Rankings: 0.119 |
DC Field | Value | Language |
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dc.contributor.author | Chan, KH | en_HK |
dc.contributor.author | Ho, SL | en_HK |
dc.date.accessioned | 2007-10-30T06:17:13Z | - |
dc.date.available | 2007-10-30T06:17:13Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | Hong Kong Practitioner, 2000, v. 22 n. 1, p. 8-20 | en_HK |
dc.identifier.issn | 1027-3948 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/45090 | - |
dc.description.abstract | Myasthenia gravis (MG) is an autoimmune disease characterised by autoantibodies against acetylcholine receptors at neuromuscular junctions, resulting in defective neuromuscular transmission. The characteristic features are fatigability and fluctuating weakness of skeletal muscles. It commonly presents with diplopia or unilateral ptosis, which are worse in the evenings. Respiratory muscle weakness may result in respiratory failure. MG is associated with various autoimmune diseases, and thymic hyperplasia or thymoma. An early diagnosis depends on a high index of suspicion, and is confirmed using tensilon test, and electromyography (EMG), and by a raised acetylcholine receptor antibody titre. Symptomatic treatment consists of cholinesterase inhibitors, corticosteroids and other immunosuppressants. Plasmapheresis or pooled intravenous human IgG (IVIgG) provides rapid but short-term relief for acute exacerbations. Thymectomy provides long-term control for patients with thymic hyperplasia, and is essential for thymomas. | en_HK |
dc.format.extent | 3059297 bytes | - |
dc.format.extent | 9894 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Hong Kong College of Family Physicians. The Journal's web site is located at http://www.hkcfp.org.hk/ | en_HK |
dc.relation.ispartof | Hong Kong Practitioner | en_HK |
dc.subject | Medical sciences | en_HK |
dc.title | An update on myasthenia gravis | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=22&issue=1&spage=8&epage=20&date=2000&atitle=An+update+on+myasthenia+gravis | en_HK |
dc.identifier.email | Ho, SL:slho@hku.hk | en_HK |
dc.identifier.authority | Ho, SL=rp00240 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.scopus | eid_2-s2.0-0034063991 | en_HK |
dc.identifier.hkuros | 49903 | - |
dc.identifier.volume | 22 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 8 | en_HK |
dc.identifier.epage | 20 | en_HK |
dc.publisher.place | Hong Kong | en_HK |
dc.identifier.scopusauthorid | Chan, KH=7406034963 | en_HK |
dc.identifier.scopusauthorid | Ho, SL=25959633500 | en_HK |
dc.identifier.issnl | 1027-3948 | - |