File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Late onset systemic lupus erythematosus in southern Chinese

TitleLate onset systemic lupus erythematosus in southern Chinese
Authors
Issue Date1998
PublisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/
Citation
Annals Of The Rheumatic Diseases, 1998, v. 57 n. 7, p. 437-440 How to Cite?
AbstractObjective - Systemic lupus erythematosus (SLE) is a multisystem disorder that predominately affects women of the reproductive age. Onset of the disease beyond the age of 50 years is unusual. This study was undertaken to compare retrospectively the clinical and laboratory features between early and late onset (onset of disease beyond the age of 50 years) SLE patients in a Chinese population. Methods - Case records of all SLE patients who attended our rheumatology clinics between 1971 and 1997 were reviewed. Patients with a disease onset beyond the age of 50 years were identified. One hundred consecutive SLE patients who had their disease onset before the age of 50 were recruited as controls. The presenting clinical features, autoantibody profile, number of major organs involved, number of major relapses, and the use of cytotoxic agents in the two groups of patients were obtained and compared. Results - 25 patients with late onset SLE were identified. All the female patients in the late onset group were postmenopausal. The female to male ratio was 3.2 to 1, compared with 13.3 to 1 in the control group (p<0.02). Both groups had a comparable duration of disease. There were no significant differences in the presenting features between the two groups except for a lower prevalence of malar rash (24% v 86%, p<0.0001) and a higher prevalence of rheumatoid factor (32% v 1%, p<0.0001) in the late onset patients. On subsequent visits, the late onset group had a lower prevalence of lupus nephritis (4% v 51%, p<0.001), fewer major organs involved (mean number of major organs involved; 0.3 v 0.9, p<0.02), fewer major relapses (mean number of major relapses/patient; 0.08 v 0.47, p<0.002, number of major relapses/patient year; 0.009 v 0.12 p<0.001), and required fewer cytotoxic agents for disease control (percentage of patients on cytotoxic agents; 32% v 79%, p<0.002). Conclusion - Late onset SLE in Chinese tends to run a more benign course with fewer major organ involvement and fewer major relapses. The significantly higher incidence of male sex in late onset SLE and the milder disease course in the postmenopausal female patients suggest that oestrogen status may influence disease activity.
Persistent Identifierhttp://hdl.handle.net/10722/45070
ISSN
2015 Impact Factor: 12.384
2015 SCImago Journal Rankings: 4.537
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, CTKen_HK
dc.contributor.authorMok, CCen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorWong, RWSen_HK
dc.date.accessioned2007-10-30T06:16:49Z-
dc.date.available2007-10-30T06:16:49Z-
dc.date.issued1998en_HK
dc.identifier.citationAnnals Of The Rheumatic Diseases, 1998, v. 57 n. 7, p. 437-440en_HK
dc.identifier.issn0003-4967en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45070-
dc.description.abstractObjective - Systemic lupus erythematosus (SLE) is a multisystem disorder that predominately affects women of the reproductive age. Onset of the disease beyond the age of 50 years is unusual. This study was undertaken to compare retrospectively the clinical and laboratory features between early and late onset (onset of disease beyond the age of 50 years) SLE patients in a Chinese population. Methods - Case records of all SLE patients who attended our rheumatology clinics between 1971 and 1997 were reviewed. Patients with a disease onset beyond the age of 50 years were identified. One hundred consecutive SLE patients who had their disease onset before the age of 50 were recruited as controls. The presenting clinical features, autoantibody profile, number of major organs involved, number of major relapses, and the use of cytotoxic agents in the two groups of patients were obtained and compared. Results - 25 patients with late onset SLE were identified. All the female patients in the late onset group were postmenopausal. The female to male ratio was 3.2 to 1, compared with 13.3 to 1 in the control group (p<0.02). Both groups had a comparable duration of disease. There were no significant differences in the presenting features between the two groups except for a lower prevalence of malar rash (24% v 86%, p<0.0001) and a higher prevalence of rheumatoid factor (32% v 1%, p<0.0001) in the late onset patients. On subsequent visits, the late onset group had a lower prevalence of lupus nephritis (4% v 51%, p<0.001), fewer major organs involved (mean number of major organs involved; 0.3 v 0.9, p<0.02), fewer major relapses (mean number of major relapses/patient; 0.08 v 0.47, p<0.002, number of major relapses/patient year; 0.009 v 0.12 p<0.001), and required fewer cytotoxic agents for disease control (percentage of patients on cytotoxic agents; 32% v 79%, p<0.002). Conclusion - Late onset SLE in Chinese tends to run a more benign course with fewer major organ involvement and fewer major relapses. The significantly higher incidence of male sex in late onset SLE and the milder disease course in the postmenopausal female patients suggest that oestrogen status may influence disease activity.en_HK
dc.format.extent107320 bytes-
dc.format.extent11668 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/en_HK
dc.relation.ispartofAnnals of the Rheumatic Diseasesen_HK
dc.rightsAnnals of the Rheumatic Diseases: the EULAR journal. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshLupus Erythematosus, Systemic - immunology - pathologyen_HK
dc.subject.meshAutoantibodies - blooden_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRheumatoid Factor - blooden_HK
dc.titleLate onset systemic lupus erythematosus in southern Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4967&volume=57&issue=7&spage=437&epage=440&date=1998&atitle=Late+onset+systemic+lupus+erythematosus+in+southern+Chineseen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9797573-
dc.identifier.pmcidPMC1752656-
dc.identifier.scopuseid_2-s2.0-0011757525en_HK
dc.identifier.hkuros40627-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0011757525&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue7en_HK
dc.identifier.spage437en_HK
dc.identifier.epage440en_HK
dc.identifier.isiWOS:000075407100012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, CTK=7404652632en_HK
dc.identifier.scopusauthoridMok, CC=34668219600en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats