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Article: Evidence-based medical practice: as viewed by a clinical researcher

TitleEvidence-based medical practice: as viewed by a clinical researcher
Authors
KeywordsClinical trials
Ethics/medical
Evidence-based medicine
Practice guidelines
Issue Date1998
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 1998, v. 4 n. 2, p. 175-182 How to Cite?
AbstractIn this era of information technology, clinicians need to understand how to conduct ethical and effective clinical research. The principles of Ը?good clinical practiceԸ? have been established to prevent mistakes and malpractice, and to protect research subjects. A researcher must carefully design the study and perform a thorough review of the literature. A detailed protocol that has been approved by the institution's Ethics Committee must be constructed before commencement of the study and followed accordingly. Comparable control group(s), recruited in a double-blind fashion, ensure that the effects observed are specific to the intervention itself. While a retrospective data review is sometimes useful, only prospective studies provide solid evidence. Outcome parameters must be defined that are clinically appropriate and measurable. Subjects should only be recruited with consent and in a randomised fashion. Elimination of inter- and intra-observer errors can be achieved by appointing an assessor (or team) and by training personnel. Proper documentation of all the events and outcome parameters is of paramount importance and is a requirement for good clinical practice. Data analysis should be done by a qualified and experienced biostatistician and the personnel involved in the study must be fully aware of their moral, legal, and scientific responsibilities and be able to work with each other.
Persistent Identifierhttp://hdl.handle.net/10722/45066
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2007-10-30T06:16:44Z-
dc.date.available2007-10-30T06:16:44Z-
dc.date.issued1998en_HK
dc.identifier.citationHong Kong Medical Journal, 1998, v. 4 n. 2, p. 175-182en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45066-
dc.description.abstractIn this era of information technology, clinicians need to understand how to conduct ethical and effective clinical research. The principles of Ը?good clinical practiceԸ? have been established to prevent mistakes and malpractice, and to protect research subjects. A researcher must carefully design the study and perform a thorough review of the literature. A detailed protocol that has been approved by the institution's Ethics Committee must be constructed before commencement of the study and followed accordingly. Comparable control group(s), recruited in a double-blind fashion, ensure that the effects observed are specific to the intervention itself. While a retrospective data review is sometimes useful, only prospective studies provide solid evidence. Outcome parameters must be defined that are clinically appropriate and measurable. Subjects should only be recruited with consent and in a randomised fashion. Elimination of inter- and intra-observer errors can be achieved by appointing an assessor (or team) and by training personnel. Proper documentation of all the events and outcome parameters is of paramount importance and is a requirement for good clinical practice. Data analysis should be done by a qualified and experienced biostatistician and the personnel involved in the study must be fully aware of their moral, legal, and scientific responsibilities and be able to work with each other.en_HK
dc.format.extent42481 bytes-
dc.format.extent21099 bytes-
dc.format.extent21721 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hken_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectClinical trialsen_HK
dc.subjectEthics/medicalen_HK
dc.subjectEvidence-based medicineen_HK
dc.subjectPractice guidelinesen_HK
dc.titleEvidence-based medical practice: as viewed by a clinical researcheren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=4&issue=2&spage=175&epage=182&date=1998&atitle=Evidence-based+medical+practice:+as+viewed+by+a+clinical+researcheren_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11832570en_HK
dc.identifier.hkuros38204-

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