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Article: The use of anti-ribosomal P antibodies in the diagnosis of cerebral lupus: superiority of western blotting over enzyme-linnked immunosorbent assay

TitleThe use of anti-ribosomal P antibodies in the diagnosis of cerebral lupus: superiority of western blotting over enzyme-linnked immunosorbent assay
Authors
KeywordsAutoantibodies - analysis
Blotting, western
Enzyme-linked immunosorbent assay
Lupus erythematosus, systemic/immunology
Ribosomal proteins/immunology
Issue Date1998
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 1998, v. 4 n. 2, p. 145-150 How to Cite?
AbstractThis study investigated the use of anti-ribosomal P antibodies in the diagnosis of cerebral complications of systemic lupus erythematosus using two different methodsԸ?western blotting and enzyme-linked immunosorbent assay. Anti-ribosomal P antibodies in patient serum were detected in both methods using a purified ribosomal P antigen substrate. Western blotting detected anti-ribosomal P antibodies with a 90% specificity for systemic lupus erythematosus in 56% of patients with the disease. The detection of anti-ribosomal P antibodies by western blotting in patients with systemic lupus erythematosus was significantly associated with psychosis and/or seizures; detection was positive in 90% of patients with these cerebral complications and in 41% of those without. Elevation of the level of anti-ribosomal P antibody, as measured by enzyme-linked immunosorbent assay, was 99% specific for systemic lupus erythematosus in 44% of patients with systemic lupus erythematosus that was not associated with cerebral involvement. We conclude that the measurement of anti-ribosomal P antibodies by western blotting is helpful in the diagnosis of cerebral lupus in selected patients.
Persistent Identifierhttp://hdl.handle.net/10722/45065
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorKo, OKHen_HK
dc.contributor.authorLawton, JWMen_HK
dc.contributor.authorLau, WCSen_HK
dc.date.accessioned2007-10-30T06:16:43Z-
dc.date.available2007-10-30T06:16:43Z-
dc.date.issued1998en_HK
dc.identifier.citationHong Kong Medical Journal, 1998, v. 4 n. 2, p. 145-150en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45065-
dc.description.abstractThis study investigated the use of anti-ribosomal P antibodies in the diagnosis of cerebral complications of systemic lupus erythematosus using two different methodsԸ?western blotting and enzyme-linked immunosorbent assay. Anti-ribosomal P antibodies in patient serum were detected in both methods using a purified ribosomal P antigen substrate. Western blotting detected anti-ribosomal P antibodies with a 90% specificity for systemic lupus erythematosus in 56% of patients with the disease. The detection of anti-ribosomal P antibodies by western blotting in patients with systemic lupus erythematosus was significantly associated with psychosis and/or seizures; detection was positive in 90% of patients with these cerebral complications and in 41% of those without. Elevation of the level of anti-ribosomal P antibody, as measured by enzyme-linked immunosorbent assay, was 99% specific for systemic lupus erythematosus in 44% of patients with systemic lupus erythematosus that was not associated with cerebral involvement. We conclude that the measurement of anti-ribosomal P antibodies by western blotting is helpful in the diagnosis of cerebral lupus in selected patients.en_HK
dc.format.extent36966 bytes-
dc.format.extent11668 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hken_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAutoantibodies - analysisen_HK
dc.subjectBlotting, westernen_HK
dc.subjectEnzyme-linked immunosorbent assayen_HK
dc.subjectLupus erythematosus, systemic/immunologyen_HK
dc.subjectRibosomal proteins/immunologyen_HK
dc.titleThe use of anti-ribosomal P antibodies in the diagnosis of cerebral lupus: superiority of western blotting over enzyme-linnked immunosorbent assayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=4&issue=2&spage=145&epage=150&date=1998&atitle=The+use+of+anti-ribosomal+P+antibodies+in+the+diagnosis+of+cerebral+lupus:+superiority+of+western+blotting+over+enzyme-linnked+immunosorbent+assayen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros38187-

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