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Article: Effectiveness of calcium acetate as a phosphate binder in patients undergoing continuous ambulatory peritoneal dialysis

TitleEffectiveness of calcium acetate as a phosphate binder in patients undergoing continuous ambulatory peritoneal dialysis
Authors
KeywordsAcetic acids - therapeutic use
Calcium carbonate/therapeutic use
Patient compliance
Peritoneal dialysis, continuous ambulatory
Phosphates/blood
Issue Date1998
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 1998, v. 4 n. 1, p. 23-26 How to Cite?
AbstractWe compared the effectiveness of calcium acetate as a phosphate binder with that of calcium carbonate by substituting one for the other in patients undergoing continuous ambulatory peritoneal dialysis. Twenty patients who had been receiving calcium carbonate as a phosphate binder were instead given calcium acetate, initially with two thirds of the previous dose of elemental calcium. The calcium acetate dose was adjusted to achieve adequate calcium-phosphate balance; 65.6% of the previous dose of elemental calcium in calcium carbonate was required. Eighteen of the 20 patients completed the 3-month study. There were no significant differences in the pre-study and study levels of serum phosphate (1.81Ը?0.04 [SEM] versus 1.89Ը?0.06 mmol/L), corrected serum calcium (2.54Ը?0.04 versus 2.57Ը?0.03 mmol/L), calcium phosphate product (4.60Ը?0.15 versus 4.87Ը?0.18), serum alkaline phosphatase (64.75Ը?4.17 versus 69.94Ը?3.77 U/L), and serum parathyroid hormone (122Ը?31 versus 124Ը?27 ng/L). Three patients developed a total of five episodes of hypercalcaemia (corrected calcium level >/=2.85 mmol/L) and four other patients developed gastrointestinal upset. Calcium acetate can thus achieve similar phosphate control to calcium carbonate, using 65.6% of the dose of elemental calcium in calcium carbonate; however, its clinical superiority was not demonstrated in this study.
Persistent Identifierhttp://hdl.handle.net/10722/45051
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChoy, CBYen_HK
dc.contributor.authorLo, WKen_HK
dc.contributor.authorCheng, IKPen_HK
dc.date.accessioned2007-10-30T06:16:26Z-
dc.date.available2007-10-30T06:16:26Z-
dc.date.issued1998en_HK
dc.identifier.citationHong Kong Medical Journal, 1998, v. 4 n. 1, p. 23-26en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45051-
dc.description.abstractWe compared the effectiveness of calcium acetate as a phosphate binder with that of calcium carbonate by substituting one for the other in patients undergoing continuous ambulatory peritoneal dialysis. Twenty patients who had been receiving calcium carbonate as a phosphate binder were instead given calcium acetate, initially with two thirds of the previous dose of elemental calcium. The calcium acetate dose was adjusted to achieve adequate calcium-phosphate balance; 65.6% of the previous dose of elemental calcium in calcium carbonate was required. Eighteen of the 20 patients completed the 3-month study. There were no significant differences in the pre-study and study levels of serum phosphate (1.81Ը?0.04 [SEM] versus 1.89Ը?0.06 mmol/L), corrected serum calcium (2.54Ը?0.04 versus 2.57Ը?0.03 mmol/L), calcium phosphate product (4.60Ը?0.15 versus 4.87Ը?0.18), serum alkaline phosphatase (64.75Ը?4.17 versus 69.94Ը?3.77 U/L), and serum parathyroid hormone (122Ը?31 versus 124Ը?27 ng/L). Three patients developed a total of five episodes of hypercalcaemia (corrected calcium level >/=2.85 mmol/L) and four other patients developed gastrointestinal upset. Calcium acetate can thus achieve similar phosphate control to calcium carbonate, using 65.6% of the dose of elemental calcium in calcium carbonate; however, its clinical superiority was not demonstrated in this study.en_HK
dc.format.extent30340 bytes-
dc.format.extent1819 bytes-
dc.format.extent2438 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hken_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAcetic acids - therapeutic useen_HK
dc.subjectCalcium carbonate/therapeutic useen_HK
dc.subjectPatient complianceen_HK
dc.subjectPeritoneal dialysis, continuous ambulatoryen_HK
dc.subjectPhosphates/blooden_HK
dc.titleEffectiveness of calcium acetate as a phosphate binder in patients undergoing continuous ambulatory peritoneal dialysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=4&issue=1&spage=23&epage=26&date=1998&atitle=Effectiveness+of+calcium+acetate+as+a+phosphate+binder+in+patients+undergoing+continuous+ambulatory+peritoneal+dialysisen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11832548en_HK
dc.identifier.scopuseid_2-s2.0-0031919807-
dc.identifier.hkuros32872-

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