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Article: Molecular detection of minimal residual disease for patients with leukemia and lymphoma
Title | Molecular detection of minimal residual disease for patients with leukemia and lymphoma |
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Authors | |
Keywords | Neoplasm, residual Leukaemia Lymphoma Polymerase chain reaction |
Issue Date | 1997 |
Publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk |
Citation | Hong Kong Medical Journal, 1997, v. 3 n. 2, p. 195-200 How to Cite? |
Abstract | Although a complete clinical remission can often be achieved with chemotherapy for patients with leukaemia and lymphoma, relapses still occur. Residual tumour cells probably have survived therapy and account for subsequent disease relapse. The sensitivity of conventioned ways of detecting residual tumour cells, such as morphological studies, immunophenotyping, and cytogenetics, is only about 1% to 5% and may be inadequate. Polymerase chain reaction technology had provided a simple and highly sensitive means for the detection of minimal residual disease. The technology has been successfully applied to study biopsy samples obtained from patients with leukaemia and lymphpma. Its clinical usefulness, however, requires further evaluation by prospective clinical studies. |
Persistent Identifier | http://hdl.handle.net/10722/45045 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Liang, RHS | en_HK |
dc.contributor.author | Chan, DW | en_HK |
dc.contributor.author | Kwong, YL | en_HK |
dc.contributor.author | Chan, VNY | en_HK |
dc.date.accessioned | 2007-10-30T06:16:18Z | - |
dc.date.available | 2007-10-30T06:16:18Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | Hong Kong Medical Journal, 1997, v. 3 n. 2, p. 195-200 | en_HK |
dc.identifier.issn | 1024-2708 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/45045 | - |
dc.description.abstract | Although a complete clinical remission can often be achieved with chemotherapy for patients with leukaemia and lymphoma, relapses still occur. Residual tumour cells probably have survived therapy and account for subsequent disease relapse. The sensitivity of conventioned ways of detecting residual tumour cells, such as morphological studies, immunophenotyping, and cytogenetics, is only about 1% to 5% and may be inadequate. Polymerase chain reaction technology had provided a simple and highly sensitive means for the detection of minimal residual disease. The technology has been successfully applied to study biopsy samples obtained from patients with leukaemia and lymphpma. Its clinical usefulness, however, requires further evaluation by prospective clinical studies. | en_HK |
dc.format.extent | 394517 bytes | - |
dc.format.extent | 517067 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.language | eng | en_HK |
dc.publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk | en_HK |
dc.subject | Neoplasm, residual | en_HK |
dc.subject | Leukaemia | en_HK |
dc.subject | Lymphoma | en_HK |
dc.subject | Polymerase chain reaction | en_HK |
dc.title | Molecular detection of minimal residual disease for patients with leukemia and lymphoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=3&issue=2&spage=195&epage=200&date=1997&atitle=Molecular+detection+of+minimal+residual+disease+for+patients+with+leukemia+and+lymphoma | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.pmid | 11850571 | en_HK |
dc.identifier.hkuros | 25479 | - |
dc.identifier.issnl | 1024-2708 | - |