Different uses of angiostensin - converting enzyme inhibitors

Abstract

The renin-angiotensin-a/dosterone system plays a keyrole in the regulation of fluid and electrolyte balance. Angiotensinconverting enzyme inhibitors (ACE/s) inhibit angiotensin-converting enzyme and have been shown to be effective in many cardiovascular diseases, including hypertension, heart failure, myocardial infarction and diabetic nephropathy. ACE/s are the most effective class of drugs in reversing left ventricular hypertrophy due to hypertension. ACE/s improve cardiac function and reduce mortality in congestive heart failure and after myocardial infarction. ACE/s should be considered in diabetics with microalbuminuria or albuminuria, especially in the presence of hypertension. There are many different ACE/s available now; they are largely similar in their effects, but differ particularly in pharmacokinetics. Choice will depend on previous experience, availability and price. There are a number of side-effects associated with ACEIs; periodic monitoring of renal function and electrolytes is required.