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Article: Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation

TitleRelationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2007, v. 44 n. 6, p. 830-837 How to Cite?
AbstractBackground. Reactivation of polyoma BK virus (BKV) infection is consistently associated with hemorrhagic cystitis in persons who undergo hematopoietic stem cell transplantation (HSCT). In this study, we examined the relationship of reactivation of BKV infection with pre-HSCT serologic findings of BKV antibody. Methods. Serial urine samples (n = 1118) obtained from 140 HSCT recipients were prospectively obtained, and BKV loads were quantified by quantitative polymerase chain reaction. Pre-HSCT anti-BKV immunoglobulin G (IgG) levels were determined by indirect immunofluorescence. Results. In 68 patients, there was significant peaking (i.e., ≥3-log increase) in the urine BKV load (median peak, 1.7 × 109 copies/mL; range, 1.1 × 10 4 to 3.2 × 1014 copies/mL) occurring at a median time of 24.5 days (range, 7-49 days). In 72 patients, low-level BKV viruria occurred without peaking (median BKV load, 10 copies/mL; range, 9.9 × 103 to 1.2 × 1010 copies/mL) at a median time of 24.5 days (range, 7-49 days). Pre-HSCT anti-BKV IgG was positively related to elevated urine BKV load during HSCT (P < .001). Binary logistic regression revealed that pre-HSCT anti-BKV IgG level was the only statistically significant factor (P = .009) to be associated with a ≥3-log increase in the peak urine BKV load (positive and negative predictive values, 69% and 68%, respectively). Nine patients developed hemorrhagic cystitis at a median of 56 days (range, 29-160); 7 of these patients were evaluable and were found to have a ≥3-log increase in the peak BKV load. In binary logistic regression, peaking of the urine BKV load (P = .026) and graft-versus-host disease (P = .033) were found to be statistically significant risks for hemorrhagic cystitis. Conclusions. The identification of the serologic status of BKV as a significant risk factor for BKV viruria suggests that it should be included as an integral part of the pre-HSCT evaluation. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/45001
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, ASYen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLeung, AYHen_HK
dc.date.accessioned2007-10-30T06:15:21Z-
dc.date.available2007-10-30T06:15:21Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical Infectious Diseases, 2007, v. 44 n. 6, p. 830-837en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45001-
dc.description.abstractBackground. Reactivation of polyoma BK virus (BKV) infection is consistently associated with hemorrhagic cystitis in persons who undergo hematopoietic stem cell transplantation (HSCT). In this study, we examined the relationship of reactivation of BKV infection with pre-HSCT serologic findings of BKV antibody. Methods. Serial urine samples (n = 1118) obtained from 140 HSCT recipients were prospectively obtained, and BKV loads were quantified by quantitative polymerase chain reaction. Pre-HSCT anti-BKV immunoglobulin G (IgG) levels were determined by indirect immunofluorescence. Results. In 68 patients, there was significant peaking (i.e., ≥3-log increase) in the urine BKV load (median peak, 1.7 × 109 copies/mL; range, 1.1 × 10 4 to 3.2 × 1014 copies/mL) occurring at a median time of 24.5 days (range, 7-49 days). In 72 patients, low-level BKV viruria occurred without peaking (median BKV load, 10 copies/mL; range, 9.9 × 103 to 1.2 × 1010 copies/mL) at a median time of 24.5 days (range, 7-49 days). Pre-HSCT anti-BKV IgG was positively related to elevated urine BKV load during HSCT (P < .001). Binary logistic regression revealed that pre-HSCT anti-BKV IgG level was the only statistically significant factor (P = .009) to be associated with a ≥3-log increase in the peak urine BKV load (positive and negative predictive values, 69% and 68%, respectively). Nine patients developed hemorrhagic cystitis at a median of 56 days (range, 29-160); 7 of these patients were evaluable and were found to have a ≥3-log increase in the peak BKV load. In binary logistic regression, peaking of the urine BKV load (P = .026) and graft-versus-host disease (P = .033) were found to be statistically significant risks for hemorrhagic cystitis. Conclusions. The identification of the serologic status of BKV as a significant risk factor for BKV viruria suggests that it should be included as an integral part of the pre-HSCT evaluation. © 2007 by the Infectious Diseases Society of America. All rights reserved.en_HK
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dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBK Virus - isolation & purificationen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effects - methodsen_HK
dc.subject.meshPolyomavirus Infections - complications - diagnosisen_HK
dc.subject.meshViral Loaden_HK
dc.subject.meshFluorescent Antibody Technique, Indirecten_HK
dc.titleRelationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=44&issue=6&spage=830&epage=837&date=2007&atitle=Relationship+of+pretransplantation+polyoma+BK+virus+serologic+findings+and+BK+viral+reactivation+after+hematopoietic+stem+cell+transplantationen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/511863en_HK
dc.identifier.pmid17304456-
dc.identifier.scopuseid_2-s2.0-33847638925en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847638925&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue6en_HK
dc.identifier.spage830en_HK
dc.identifier.epage837en_HK
dc.identifier.isiWOS:000244242500012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, ASY=7403144356en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK

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