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Article: Nicotine induced gastric injury A quantitative macroscopic and microscopic analysis of the protective effects of sucralfate and feeding

TitleNicotine induced gastric injury A quantitative macroscopic and microscopic analysis of the protective effects of sucralfate and feeding
Authors
Issue Date1991
PublisherB M J Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 1991, v. 32 n. 4, p. 372-376 How to Cite?
AbstractNicotine, while an important component of cigarettes, does not cause gross gastric mucosal damage, although its microscopic effect remains unknown. We have evaluated the histology and the microvascular permeability of (a) the effect of nicotine alone or in combination with ethanol on the gastric mucosa of rats and (b) the effect of feeding and sucralfate on the mucosa of rats treated with nicotine and ethanol. Mucosal injury was assessed histologically by the depth of injury and microvascular permeability by the leakage of fluorescein isothiocyanate-labelled albumin. Our results show that nicotine induced microscopic mucosal damage and accentuated the damage induced by alcohol. The damaging effects on mucosa of nicotine and ethanol, alone or in combination, were reduced by pretreatment with sucralfate. Similarly, feeding reduced the degree of mucosal injury. Nicotine and ethanol increased leakage of albumin into the interstitium and the leakage was reduced after sucralfate pretreatment. This study substantiates the adverse effect of smoking on mucosal damage. Vascular factors are probably involved in the pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/44979
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, WMen_HK
dc.contributor.authorJoana, Hen_HK
dc.contributor.authorChen, BWen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorLuk, CTen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2007-10-30T06:14:52Z-
dc.date.available2007-10-30T06:14:52Z-
dc.date.issued1991en_HK
dc.identifier.citationGut, 1991, v. 32 n. 4, p. 372-376en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44979-
dc.description.abstractNicotine, while an important component of cigarettes, does not cause gross gastric mucosal damage, although its microscopic effect remains unknown. We have evaluated the histology and the microvascular permeability of (a) the effect of nicotine alone or in combination with ethanol on the gastric mucosa of rats and (b) the effect of feeding and sucralfate on the mucosa of rats treated with nicotine and ethanol. Mucosal injury was assessed histologically by the depth of injury and microvascular permeability by the leakage of fluorescein isothiocyanate-labelled albumin. Our results show that nicotine induced microscopic mucosal damage and accentuated the damage induced by alcohol. The damaging effects on mucosa of nicotine and ethanol, alone or in combination, were reduced by pretreatment with sucralfate. Similarly, feeding reduced the degree of mucosal injury. Nicotine and ethanol increased leakage of albumin into the interstitium and the leakage was reduced after sucralfate pretreatment. This study substantiates the adverse effect of smoking on mucosal damage. Vascular factors are probably involved in the pathogenesis.en_HK
dc.format.extent1035429 bytes-
dc.format.extent3803 bytes-
dc.format.extent5131 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGut. Copyright © B M J Publishing Group.en_HK
dc.subject.meshFood-en_HK
dc.subject.meshGastric-Mucosa-drug-effectsen_HK
dc.subject.meshNicotine-toxicityen_HK
dc.subject.meshSucralfate-pharmacologyen_HK
dc.titleNicotine induced gastric injury A quantitative macroscopic and microscopic analysis of the protective effects of sucralfate and feedingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=32&issue=4&spage=372&epage=376&date=1991&atitle=Nicotine+induced+gastric+injury+A+quantitative+macroscopic+and+microscopic+analysis+of+the+protective+effects+of+sucralfate+and+feedingen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid2026336-
dc.identifier.pmcidPMC1379073-
dc.identifier.scopuseid_2-s2.0-0025801671-
dc.identifier.isiWOS:A1991FG25200007-

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