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Article: Development of the mammalian retinogeniculate pathway: Target finding, transient synapses and binocular segregation

TitleDevelopment of the mammalian retinogeniculate pathway: Target finding, transient synapses and binocular segregation
Authors
Issue Date1990
PublisherCompany of Biologists Ltd.
Citation
Journal Of Experimental Biology, 1990, v. 153, p. 85-104 How to Cite?
AbstractThis review is concerned with the development of the mammalian retinogeniculate projection from the perspective of our studies on the hamster and to a lesser extent on the cat. In these, and other mammalian species, axons from the two eyes initially spread throughout the dorsal lateral geniculate nucleus (dLGN) and thus completely overlap. Later they segregate, the axons from each eye coming to occupy discrete, non-overlapping territories within the dLGN. The process of segregation to establish the adult pattern coincides with the death of retinal ganglion cells projecting to inappropriate areas of the dLGN and with the loss, by degeneration or retraction, of the axons and/or axonal branches initially located within inappropriate territory of the dLGN. These events occur in the early postnatal period in hamsters, before the eyes have opened, and in cats and monkeys they occur entirely during embryonic life: thus, they do not depend on the onset of normal visual function. If one eye is removed before segregation has begun, the terminal fields of the crossed and uncrossed axons from the remaining eye do not segregate, suggesting that segregation in normal development may depend on some form of interaction between retinal ganglion cells from the two eyes. Attractive and/or repulsive influences exerted by the dLGN on retinogeniculate axons may also be involved in the formation of eye-specific territories. Experimental ultrastructural studies in hamster and cat show that the overlap phase is associated with the formation, by inappropriately located axons, of transient synapses similar to those made by retinogeniculate axons in appropriate parts of the dLGN. In the cat, the transient synapses are made by the axon trunk and by side branches of retinogeniculate axons with terminal arbors in appropriate parts of the nucleus; the transient synapses disappear as the side branches are shed or retracted during the segregation period. Because of good evidence that electrical activity of the retinogeniculate axons may be involved in binocular segregation of inputs, we suggest that the formation and elimination of transient synapses play a significant role in the development of the orderly retinogeniculate projections.
Persistent Identifierhttp://hdl.handle.net/10722/44572
ISSN
2015 Impact Factor: 2.914
2015 SCImago Journal Rankings: 1.815
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_HK
dc.contributor.authorCampbell, Gen_HK
dc.contributor.authorLieberman, ARen_HK
dc.date.accessioned2007-10-30T06:04:38Z-
dc.date.available2007-10-30T06:04:38Z-
dc.date.issued1990en_HK
dc.identifier.citationJournal Of Experimental Biology, 1990, v. 153, p. 85-104en_HK
dc.identifier.issn0022-0949en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44572-
dc.description.abstractThis review is concerned with the development of the mammalian retinogeniculate projection from the perspective of our studies on the hamster and to a lesser extent on the cat. In these, and other mammalian species, axons from the two eyes initially spread throughout the dorsal lateral geniculate nucleus (dLGN) and thus completely overlap. Later they segregate, the axons from each eye coming to occupy discrete, non-overlapping territories within the dLGN. The process of segregation to establish the adult pattern coincides with the death of retinal ganglion cells projecting to inappropriate areas of the dLGN and with the loss, by degeneration or retraction, of the axons and/or axonal branches initially located within inappropriate territory of the dLGN. These events occur in the early postnatal period in hamsters, before the eyes have opened, and in cats and monkeys they occur entirely during embryonic life: thus, they do not depend on the onset of normal visual function. If one eye is removed before segregation has begun, the terminal fields of the crossed and uncrossed axons from the remaining eye do not segregate, suggesting that segregation in normal development may depend on some form of interaction between retinal ganglion cells from the two eyes. Attractive and/or repulsive influences exerted by the dLGN on retinogeniculate axons may also be involved in the formation of eye-specific territories. Experimental ultrastructural studies in hamster and cat show that the overlap phase is associated with the formation, by inappropriately located axons, of transient synapses similar to those made by retinogeniculate axons in appropriate parts of the dLGN. In the cat, the transient synapses are made by the axon trunk and by side branches of retinogeniculate axons with terminal arbors in appropriate parts of the nucleus; the transient synapses disappear as the side branches are shed or retracted during the segregation period. Because of good evidence that electrical activity of the retinogeniculate axons may be involved in binocular segregation of inputs, we suggest that the formation and elimination of transient synapses play a significant role in the development of the orderly retinogeniculate projections.en_HK
dc.format.extent3678060 bytes-
dc.format.extent2945 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCompany of Biologists Ltd.en_HK
dc.relation.ispartofJournal of Experimental Biologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshGeniculate-Bodies-physiologyen_HK
dc.subject.meshRetina-physiologyen_HK
dc.subject.meshSynapses-physiologyen_HK
dc.subject.meshVision,-Binocularen_HK
dc.subject.meshVisual-Pathways-physiologyen_HK
dc.titleDevelopment of the mammalian retinogeniculate pathway: Target finding, transient synapses and binocular segregationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0949&volume=153&spage=85&epage=104&date=1990&atitle=Development+of+the+mammalian+retinogeniculate+pathway:+target+finding,+transient+synapses+and+binocular+segregationen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid2280230-
dc.identifier.scopuseid_2-s2.0-0025154854en_HK
dc.identifier.volume153en_HK
dc.identifier.spage85en_HK
dc.identifier.epage104en_HK
dc.identifier.isiWOS:A1990EG83700008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridCampbell, G=7401889253en_HK
dc.identifier.scopusauthoridLieberman, AR=7202118609en_HK

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