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Article: Retinal ganglion cells toxicity caused by photosensitising effects of intravitreal indocyanine green with illumination in rat eyes

TitleRetinal ganglion cells toxicity caused by photosensitising effects of intravitreal indocyanine green with illumination in rat eyes
Authors
Issue Date2006
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2006, v. 90 n. 1, p. 99-102 How to Cite?
AbstractAim: To investigate the effects of indocyanine green (ICG) with or without illumination on rat retinal ganglion cells (RGC) and retinal morphology. Methods: Intravitreal injections of 1.0 mg/ml ICG solution were performed in rat eyes with or without subsequent illumination for 5 minutes. Eyes in the control group had intravitreal injections of balanced salt solution with illumination. Retrograde labelling of RGC with 6% Fluoro-Gold was performed 1 month later and RGC densities were compared between the three groups. Light microscopy with measurements of outer nuclear layer (ONL) and inner nuclear layer (INL) thicknesses were also performed and compared. Results: Eyes with ICG without illumination showed insignificant reduction in RGC density compared with the control group (p = 0.28), whereas a significant decrease in RGC density was found in eyes that had ICG injection with illumination (p = 0.036). A significant increase in ONL thickness was also observed in the ICG with illumination treated eyes compared with the ICG without illumination and the control groups (p<0.001). No significant difference in INL thickness was observed between the three groups. Conclusions: Intravitreal injection of 0.1 mg/ml ICG in rat eyes followed by illumination resulted in photosensitising toxicity to RGC. Lower ICG concentration or illumination level should be considered when performing ICG assisted macular surgery.
Persistent Identifierhttp://hdl.handle.net/10722/44567
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYip, HKFen_HK
dc.contributor.authorLai, TYYen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorKwok, AKHen_HK
dc.date.accessioned2007-10-30T06:04:29Z-
dc.date.available2007-10-30T06:04:29Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2006, v. 90 n. 1, p. 99-102en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44567-
dc.description.abstractAim: To investigate the effects of indocyanine green (ICG) with or without illumination on rat retinal ganglion cells (RGC) and retinal morphology. Methods: Intravitreal injections of 1.0 mg/ml ICG solution were performed in rat eyes with or without subsequent illumination for 5 minutes. Eyes in the control group had intravitreal injections of balanced salt solution with illumination. Retrograde labelling of RGC with 6% Fluoro-Gold was performed 1 month later and RGC densities were compared between the three groups. Light microscopy with measurements of outer nuclear layer (ONL) and inner nuclear layer (INL) thicknesses were also performed and compared. Results: Eyes with ICG without illumination showed insignificant reduction in RGC density compared with the control group (p = 0.28), whereas a significant decrease in RGC density was found in eyes that had ICG injection with illumination (p = 0.036). A significant increase in ONL thickness was also observed in the ICG with illumination treated eyes compared with the ICG without illumination and the control groups (p<0.001). No significant difference in INL thickness was observed between the three groups. Conclusions: Intravitreal injection of 0.1 mg/ml ICG in rat eyes followed by illumination resulted in photosensitising toxicity to RGC. Lower ICG concentration or illumination level should be considered when performing ICG assisted macular surgery.en_HK
dc.format.extent107958 bytes-
dc.format.extent2945 bytes-
dc.format.extent2857 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsBritish Journal of Ophthalmology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshIndocyanine-Green-toxicityen_HK
dc.subject.meshRetinal-Ganglion-Cells-drug-effectsen_HK
dc.titleRetinal ganglion cells toxicity caused by photosensitising effects of intravitreal indocyanine green with illumination in rat eyesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1161&volume=90&issue=1&spage=99&epage=102&date=2006&atitle=Retinal+ganglion+cells+toxicity+caused+by+photosensitising+effects+of+intravitreal+indocyanine+green+with+illumination+in+rat+eyesen_HK
dc.identifier.emailYip, HKF:hkfyip@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityYip, HKF=rp00285en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/bjo.2005.076042en_HK
dc.identifier.pmid16361677-
dc.identifier.pmcidPMC1856904-
dc.identifier.scopuseid_2-s2.0-29744433827en_HK
dc.identifier.hkuros115064-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29744433827&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue1en_HK
dc.identifier.spage99en_HK
dc.identifier.epage102en_HK
dc.identifier.isiWOS:000233994900026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYip, HKF=7101980864en_HK
dc.identifier.scopusauthoridLai, TYY=7202203581en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridKwok, AKH=7005913424en_HK

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