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Article: Peri-operative administration of rectal diclofenac sodium. The effect on renal function in patients undergoing minor orthopaedic surgery

TitlePeri-operative administration of rectal diclofenac sodium. The effect on renal function in patients undergoing minor orthopaedic surgery
Authors
KeywordsAnalgesics, diclofenac pethidine
Enzymes, lysosomal, N-acetyl-b-D-glucosaminidase
Kidney, function, nephrotoxicity
Toxicity, renal
Issue Date1995
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=EJA
Citation
European Journal Of Anaesthesiology, 1995, v. 12 n. 4, p. 403-406 How to Cite?
AbstractIn a randomized, double-blind study, we administered placebo and diclofenac sodium 100 mg suppositories 1 h pre-operatively and on the first post-operative morning to 22 adult patients undergoing minor orthopaedic surgery. A standardized post-operative intravenous fluid regimen was instituted until oral fluids were tolerated. Renal function was assessed pre-operatively, and on the first and second post-operative days by the measurement of urine output, creatinine, urea, sodium, potassium and NAG (N-acetyl-b-D-glucosaminidase) levels and serum creatinine, urea, sodium and potassium concentrations. On the first postoperative day, the diclofenac group demonstrated a reduced urinary sodium excretion. On the second postoperative day, a reduced urinary NAG/creatinine ratio was observed in the diclofenac group when compared to placebo. We conclude that peri-operative administration of diclofenac causes changes in renal function consistent with prostaglandin inhibition on the first post-operative day but had no lasting adverse effects in this group of patients. Our results reinforce the need for caution when administering this drug in the context of pre-existing renal impairment.
Persistent Identifierhttp://hdl.handle.net/10722/44558
ISSN
2015 Impact Factor: 3.634
2015 SCImago Journal Rankings: 0.999
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorRoulson, CJen_HK
dc.contributor.authorJones, RDMen_HK
dc.contributor.authorCheng, IKPen_HK
dc.contributor.authorVisram, ARen_HK
dc.contributor.authorChan, YMen_HK
dc.date.accessioned2007-10-30T06:04:13Z-
dc.date.available2007-10-30T06:04:13Z-
dc.date.issued1995en_HK
dc.identifier.citationEuropean Journal Of Anaesthesiology, 1995, v. 12 n. 4, p. 403-406en_HK
dc.identifier.issn0265-0215en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44558-
dc.description.abstractIn a randomized, double-blind study, we administered placebo and diclofenac sodium 100 mg suppositories 1 h pre-operatively and on the first post-operative morning to 22 adult patients undergoing minor orthopaedic surgery. A standardized post-operative intravenous fluid regimen was instituted until oral fluids were tolerated. Renal function was assessed pre-operatively, and on the first and second post-operative days by the measurement of urine output, creatinine, urea, sodium, potassium and NAG (N-acetyl-b-D-glucosaminidase) levels and serum creatinine, urea, sodium and potassium concentrations. On the first postoperative day, the diclofenac group demonstrated a reduced urinary sodium excretion. On the second postoperative day, a reduced urinary NAG/creatinine ratio was observed in the diclofenac group when compared to placebo. We conclude that peri-operative administration of diclofenac causes changes in renal function consistent with prostaglandin inhibition on the first post-operative day but had no lasting adverse effects in this group of patients. Our results reinforce the need for caution when administering this drug in the context of pre-existing renal impairment.en_HK
dc.format.extent268389 bytes-
dc.format.extent1101122 bytes-
dc.format.extent2438 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=EJAen_HK
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsEuropean Journal of Anaesthesiology. Copyright © Cambridge University Press.en_HK
dc.subjectAnalgesics, diclofenac pethidineen_HK
dc.subjectEnzymes, lysosomal, N-acetyl-b-D-glucosaminidaseen_HK
dc.subjectKidney, function, nephrotoxicityen_HK
dc.subjectToxicity, renalen_HK
dc.subject.meshAnti-Inflammatory-Agents,-Non-Steroidal-administration-and-dosageen_HK
dc.subject.meshBone-and-Bones-surgeryen_HK
dc.subject.meshCyclooxygenase-Inhibitors-administration-and-dosageen_HK
dc.subject.meshDiclofenac-administration-and-dosageen_HK
dc.subject.meshKidney-drug-effectsen_HK
dc.titlePeri-operative administration of rectal diclofenac sodium. The effect on renal function in patients undergoing minor orthopaedic surgeryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0265-0215&volume=12&issue=4&spage=403&epage=406&date=1995&atitle=Peri-operative+administration+of+rectal+diclofenac+sodium.+The+effect+on+renal+function+in+patients+undergoing+minor+orthopaedic+surgeryen_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7588670-
dc.identifier.scopuseid_2-s2.0-0029091685en_HK
dc.identifier.hkuros10576-
dc.identifier.volume12en_HK
dc.identifier.issue4en_HK
dc.identifier.spage403en_HK
dc.identifier.epage406en_HK
dc.identifier.isiWOS:A1995RN39700011-
dc.publisher.placeUnited Kingdomen_HK

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