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Article: Glucose intolerance in children with cystic fibrosis

TitleGlucose intolerance in children with cystic fibrosis
Authors
Issue Date2003
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpeds
Citation
Journal Of Pediatrics, 2003, v. 142 n. 2, p. 128-132 How to Cite?
Abstract
Objective: To evaluate the relations among glucose intolerance, genotype, and exocrine pancreatic status in patients with cystic fibrosis (CF). Study design: Data on 335 patients <18 years of age were from the Toronto CF database. A modified oral glucose tolerance test was given to 94 patients 10 to 18 years of age without recognized CF-related diabetes. CF transmembrane conductance regulator mutations and exocrine pancreatic status were determined for all patients. Results: CF-related diabetes was clinically recognized in 9 of 335 (2.7%) patients <18 years of age, all of whom were pancreatic insufficient, and 8 of 9 had severe (classes I through III) mutations on both alleles. The ninth patient had unidentified mutations. Although all patients given the oral glucose tolerance test were asymptomatic and had normal fasting blood glucose, 16 of 94 (17%) had impaired glucose tolerance and 4 of 94 (4.3%) had CF-related diabetes without fasting hyperglycemia. Abnormal glucose tolerance was associated exclusively with severe mutations and exocrine pancreatic insufficiency. Glycosylated hemoglobin (HbA 1C) levels did not correlate with glucose tolerance results. Conclusions: Screening of pancreatic-insufficient, adolescent patients with CF identified more with abnormal oral glucose tolerance than was suspected clinically and is recommended as a routine practice. HbA 1C was not useful in screening for CF-related glucose intolerance.
Persistent Identifierhttp://hdl.handle.net/10722/44380
ISSN
2013 Impact Factor: 3.736
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSolomon, MPen_HK
dc.contributor.authorWilson, DCen_HK
dc.contributor.authorCorey, Men_HK
dc.contributor.authorKalnins, Den_HK
dc.contributor.authorZielenski, Jen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorPencharz, Pen_HK
dc.contributor.authorDurie, Pen_HK
dc.contributor.authorSweezey, NBen_HK
dc.date.accessioned2007-09-12T03:52:25Z-
dc.date.available2007-09-12T03:52:25Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Pediatrics, 2003, v. 142 n. 2, p. 128-132en_HK
dc.identifier.issn0022-3476en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44380-
dc.description.abstractObjective: To evaluate the relations among glucose intolerance, genotype, and exocrine pancreatic status in patients with cystic fibrosis (CF). Study design: Data on 335 patients <18 years of age were from the Toronto CF database. A modified oral glucose tolerance test was given to 94 patients 10 to 18 years of age without recognized CF-related diabetes. CF transmembrane conductance regulator mutations and exocrine pancreatic status were determined for all patients. Results: CF-related diabetes was clinically recognized in 9 of 335 (2.7%) patients <18 years of age, all of whom were pancreatic insufficient, and 8 of 9 had severe (classes I through III) mutations on both alleles. The ninth patient had unidentified mutations. Although all patients given the oral glucose tolerance test were asymptomatic and had normal fasting blood glucose, 16 of 94 (17%) had impaired glucose tolerance and 4 of 94 (4.3%) had CF-related diabetes without fasting hyperglycemia. Abnormal glucose tolerance was associated exclusively with severe mutations and exocrine pancreatic insufficiency. Glycosylated hemoglobin (HbA 1C) levels did not correlate with glucose tolerance results. Conclusions: Screening of pancreatic-insufficient, adolescent patients with CF identified more with abnormal oral glucose tolerance than was suspected clinically and is recommended as a routine practice. HbA 1C was not useful in screening for CF-related glucose intolerance.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpedsen_HK
dc.relation.ispartofJournal of Pediatricsen_HK
dc.subject.meshCystic Fibrosis - complications - geneticsen_HK
dc.subject.meshDiabetes Mellitus - blood - diagnosis - epidemiology - etiologyen_HK
dc.subject.meshGlucose Intolerance - blood - diagnosis - epidemiology - etiologyen_HK
dc.subject.meshHemoglobin A, Glycosylated - metabolismen_HK
dc.subject.meshMass Screening - methodsen_HK
dc.titleGlucose intolerance in children with cystic fibrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3476&volume=142&issue=2&spage=128&epage=132&date=2003&atitle=Glucose+intolerance+in+children+with+cystic+fibrosisen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.natureabstracten_HK
dc.identifier.doi10.1067/mpd.2003.5en_HK
dc.identifier.pmid12584532en_HK
dc.identifier.scopuseid_2-s2.0-0037326312en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037326312&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume142en_HK
dc.identifier.issue2en_HK
dc.identifier.spage128en_HK
dc.identifier.epage132en_HK
dc.identifier.isiWOS:000181144400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSolomon, MP=7202021353en_HK
dc.identifier.scopusauthoridWilson, DC=9035958000en_HK
dc.identifier.scopusauthoridCorey, M=7005819978en_HK
dc.identifier.scopusauthoridKalnins, D=7801381520en_HK
dc.identifier.scopusauthoridZielenski, J=7003732699en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridPencharz, P=7102429571en_HK
dc.identifier.scopusauthoridDurie, P=7005360997en_HK
dc.identifier.scopusauthoridSweezey, NB=6701894781en_HK

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