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Article: Loci of intestinal distress in cystic fibrosis knockout mice

TitleLoci of intestinal distress in cystic fibrosis knockout mice
Authors
KeywordsModifier gene
Transmission distortion
Issue Date2003
PublisherAmerican Physiological Society.
Citation
Physiological Genomics, 2003, v. 12, p. 79-84 How to Cite?
AbstractThe strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 × 10-4) to predict for intestinal distress in CF male mice. An × chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/44379
ISSN
2015 SCImago Journal Rankings: 1.545
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHaston, CKen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:52:24Z-
dc.date.available2007-09-12T03:52:24Z-
dc.date.issued2003en_HK
dc.identifier.citationPhysiological Genomics, 2003, v. 12, p. 79-84en_HK
dc.identifier.issn1531-2267en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44379-
dc.description.abstractThe strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 × 10-4) to predict for intestinal distress in CF male mice. An × chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Society.en_HK
dc.relation.ispartofPhysiological Genomicsen_HK
dc.subjectModifier geneen_HK
dc.subjectTransmission distortionen_HK
dc.subject.meshCystic fibrosis - genetics - physiopathologyen_HK
dc.subject.meshCystic fibrosis transmembrane conductance regulator - deficiency - geneticsen_HK
dc.subject.meshGenetic markers - genetics - physiologyen_HK
dc.subject.meshIntestinal diseases - genetics - physiopathologyen_HK
dc.subject.meshMice, inbred balb cen_HK
dc.titleLoci of intestinal distress in cystic fibrosis knockout miceen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1152/physiolgenomics.00114.2002en_HK
dc.identifier.pmid12441405-
dc.identifier.scopuseid_2-s2.0-0037678280en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037678280&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.spage79en_HK
dc.identifier.epage84en_HK
dc.identifier.isiWOS:000180400100003-
dc.identifier.scopusauthoridHaston, CK=6602880337en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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