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Article: Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice

TitleMapping of genetic factors influencing the weight of cystic fibrosis knockout mice
Authors
Issue Date2002
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/
Citation
Mammalian Genome, 2002, v. 13 n. 11, p. 614-618 How to Cite?
AbstractOne of the poorly understood clinical manifestations of cystic fibrosis (CF) is low body weight. Mice in which the CF causative gene, cystic fibrosis transmembrane conductance regulator (Cftr), has been knocked out reflect this as they are smaller than age-matched littermates. The variable weight of F2 Cftr -/- (CF) mice derived from a cross between congenic C57BL/6J and BALB/cJ Cftr heterozygotic mice permits the mapping of modifiers of this cystic fibrosis phenotype. In this report, quantitative trait loci (QTL) mapping was used to identify the chromosomal locations of genes that contribute to the body weight of 12-week-old F2 CF mice. Five loci of CF body weight were detected with four of the five acting in a sex-specific manner. Significant linkage of the phenotype to a region of Chromosome (Chr) 13 from D13Mit179 to D13Mit254 (LOD = 4.2) was established in female mice; and suggestive loci on Chrs 7 and 10 were identified. The weights of F2 male CF mice were suggestively linked to regions of Chrs 1 and 6, and to the same locus on Chr 7 as in female mice. The suggestive loci did not influence the weight of the limited set of control mice and thus are presumed to be CF specific in their effects. Further study of these putative CF body weight modifiers may provide insight on the pathogenesis of cystic fibrosis.
Persistent Identifierhttp://hdl.handle.net/10722/44377
ISSN
2015 Impact Factor: 2.078
2015 SCImago Journal Rankings: 2.082
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHaston, CKen_HK
dc.contributor.authorCorey, Men_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:52:22Z-
dc.date.available2007-09-12T03:52:22Z-
dc.date.issued2002en_HK
dc.identifier.citationMammalian Genome, 2002, v. 13 n. 11, p. 614-618en_HK
dc.identifier.issn0938-8990en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44377-
dc.description.abstractOne of the poorly understood clinical manifestations of cystic fibrosis (CF) is low body weight. Mice in which the CF causative gene, cystic fibrosis transmembrane conductance regulator (Cftr), has been knocked out reflect this as they are smaller than age-matched littermates. The variable weight of F2 Cftr -/- (CF) mice derived from a cross between congenic C57BL/6J and BALB/cJ Cftr heterozygotic mice permits the mapping of modifiers of this cystic fibrosis phenotype. In this report, quantitative trait loci (QTL) mapping was used to identify the chromosomal locations of genes that contribute to the body weight of 12-week-old F2 CF mice. Five loci of CF body weight were detected with four of the five acting in a sex-specific manner. Significant linkage of the phenotype to a region of Chromosome (Chr) 13 from D13Mit179 to D13Mit254 (LOD = 4.2) was established in female mice; and suggestive loci on Chrs 7 and 10 were identified. The weights of F2 male CF mice were suggestively linked to regions of Chrs 1 and 6, and to the same locus on Chr 7 as in female mice. The suggestive loci did not influence the weight of the limited set of control mice and thus are presumed to be CF specific in their effects. Further study of these putative CF body weight modifiers may provide insight on the pathogenesis of cystic fibrosis.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/en_HK
dc.relation.ispartofMammalian Genomeen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.subject.meshBody weight - geneticsen_HK
dc.subject.meshCystic fibrosis - geneticsen_HK
dc.subject.meshMice, inbred balb cen_HK
dc.subject.meshMice, inbred c57blen_HK
dc.subject.meshChromosome mappingen_HK
dc.titleMapping of genetic factors influencing the weight of cystic fibrosis knockout miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0938-8990&volume=13&issue=11&spage=614&epage=618&date=2002&atitle=Mapping+of+genetic+factors+influencing+the+weight+of+cystic+fibrosis+knockout+miceen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1007/s00335-002-2195-2en_HK
dc.identifier.pmid12461646en_HK
dc.identifier.scopuseid_2-s2.0-0036855271en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036855271&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue11en_HK
dc.identifier.spage614en_HK
dc.identifier.epage618en_HK
dc.identifier.isiWOS:000179616200002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHaston, CK=6602880337en_HK
dc.identifier.scopusauthoridCorey, M=7005819978en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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