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Article: Circling, deafness, and yellow coat displayed by yellow submarine (Ysb) and light coat and circling (Lcc) mice with mutations on chromosome 3

TitleCircling, deafness, and yellow coat displayed by yellow submarine (Ysb) and light coat and circling (Lcc) mice with mutations on chromosome 3
Authors
KeywordsChromosome 3
Deaf
Ear
Hair
Mouse
Pigmentation
Transgenic
X-irradiation
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 2002, v. 79 n. 6, p. 777-784 How to Cite?
AbstractWe describe here two mouse mutants, yellow submarine (Ysb) and light coat and circling (Lcc). Ysb arose as the result of insertions of a transgene, pAA2, into the genome. Lcc is an independent, radiation-induced mutation. Both mutants are characterized by recessive circling behavior and deafness, associated with a non-segregating, semi-dominant yellow coat color. Complementation tests showed that Ysb and Lcc are allelic. We attribute the yellow coat in Ysb and Lcc mice to the absence of black awl overhairs, increased agouti zigzag underhairs, and the presence of agouti awls with long subapical yellow pigment. Chromosomal mapping and genomic characterization showed the Ysb and Lcc mutations involve complex chromosomal rearrangements in overlapping regions of mouse chromosome 3, A2/A3-B/C and B-E1, respectively. Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair.
Persistent Identifierhttp://hdl.handle.net/10722/44371
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDong, Sen_HK
dc.contributor.authorLeung, KKHen_HK
dc.contributor.authorPelling, ALen_HK
dc.contributor.authorLee, PYTen_HK
dc.contributor.authorTang, ASPen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorTease, Cen_HK
dc.contributor.authorFisher, Gen_HK
dc.contributor.authorSteel, KPen_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2007-09-12T03:52:16Z-
dc.date.available2007-09-12T03:52:16Z-
dc.date.issued2002en_HK
dc.identifier.citationGenomics, 2002, v. 79 n. 6, p. 777-784en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44371-
dc.description.abstractWe describe here two mouse mutants, yellow submarine (Ysb) and light coat and circling (Lcc). Ysb arose as the result of insertions of a transgene, pAA2, into the genome. Lcc is an independent, radiation-induced mutation. Both mutants are characterized by recessive circling behavior and deafness, associated with a non-segregating, semi-dominant yellow coat color. Complementation tests showed that Ysb and Lcc are allelic. We attribute the yellow coat in Ysb and Lcc mice to the absence of black awl overhairs, increased agouti zigzag underhairs, and the presence of agouti awls with long subapical yellow pigment. Chromosomal mapping and genomic characterization showed the Ysb and Lcc mutations involve complex chromosomal rearrangements in overlapping regions of mouse chromosome 3, A2/A3-B/C and B-E1, respectively. Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subjectChromosome 3en_HK
dc.subjectDeafen_HK
dc.subjectEaren_HK
dc.subjectHairen_HK
dc.subjectMouseen_HK
dc.subjectPigmentationen_HK
dc.subjectTransgenicen_HK
dc.subjectX-irradiationen_HK
dc.subject.meshDeafness - geneticsen_HK
dc.subject.meshMutation - radiation effectsen_HK
dc.subject.meshPigmentation - genetics - radiation effectsen_HK
dc.subject.meshPostural Balance - physiology - radiation effectsen_HK
dc.subject.meshPostural Balance - physiology - radiation effectsen_HK
dc.titleCircling, deafness, and yellow coat displayed by yellow submarine (Ysb) and light coat and circling (Lcc) mice with mutations on chromosome 3en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=79&issue=6&spage=777&epage=784&date=2002&atitle=Circling,+deafness,+and+yellow+coat+displayed+by+yellow+submarine+(ysb)+and+light+coat+and+circling+(lcc)+mice+with+mutations+on+chromosome+3en_HK
dc.identifier.emailLeung, KKH: keithlee@hku.hken_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.authorityLeung, KKH=rp00298en_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.2002.6783en_HK
dc.identifier.pmid12036291-
dc.identifier.scopuseid_2-s2.0-0036271852en_HK
dc.identifier.hkuros69488-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036271852&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue6en_HK
dc.identifier.spage777en_HK
dc.identifier.epage784en_HK
dc.identifier.isiWOS:000175963600007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDong, S=36837767100en_HK
dc.identifier.scopusauthoridLeung, KKH=7401860467en_HK
dc.identifier.scopusauthoridPelling, AL=6602962713en_HK
dc.identifier.scopusauthoridLee, PYT=37056380600en_HK
dc.identifier.scopusauthoridTang, ASP=8384496800en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridTease, C=7004043261en_HK
dc.identifier.scopusauthoridFisher, G=7402440339en_HK
dc.identifier.scopusauthoridSteel, KP=7102712349en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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