File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

TitleDysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations
Authors
Keywords7q translocations
CDK6
SLVL
SMZL
Issue Date1999
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1999, v. 18 n. 46, p. 6271-6277 How to Cite?
AbstractThe increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the pathogenesis of B-cell lymphoproliferative diseases. Recent studies have found deletions or translocations of chromosome 7q to be the most common cytogenetic abnormality observed in SLVL, a leukemic variant of SMZL, with the q21-q22 region being most frequently affected. In three patients with translocations between chromosomes 2 and 7, the cloning of the breakpoints at 7q21 revealed that each was located within a small region of DNA 3.6 kb upstream of the transcription start site of cyclin dependent kinase 6 (CDK6). In each case the translocation event was consistent with aberrant VJ recombination between the immunoglobulin light chain region (Ig kappa) on chromosome 2p12 and DNA sequences at 7q21, resembling the heptamer recombination site, The t(7;21) breakpoint in an additional patient with splenic marginal zone lymphoma (SMZL), resided 66 kb telomeric to the t(2;7) breakpoints juxtaposing CDK6 to an uncharacterized transcript. In two of the SLVL patient samples, the CDK6 protein was found to be markedly over expressed. These results suggest that dysregulation of CDK6 gene expression contributes to the pathogenesis of SLVL and SMZL.
Persistent Identifierhttp://hdl.handle.net/10722/44355
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCorcoran, MMen_HK
dc.contributor.authorMould, SJen_HK
dc.contributor.authorOrchard, JAen_HK
dc.contributor.authorIbbotson, REen_HK
dc.contributor.authorChapman, RMen_HK
dc.contributor.authorBoright, APen_HK
dc.contributor.authorPlatt, Cen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorOscier, DGen_HK
dc.date.accessioned2007-09-12T03:52:00Z-
dc.date.available2007-09-12T03:52:00Z-
dc.date.issued1999en_HK
dc.identifier.citationOncogene, 1999, v. 18 n. 46, p. 6271-6277en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44355-
dc.description.abstractThe increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the pathogenesis of B-cell lymphoproliferative diseases. Recent studies have found deletions or translocations of chromosome 7q to be the most common cytogenetic abnormality observed in SLVL, a leukemic variant of SMZL, with the q21-q22 region being most frequently affected. In three patients with translocations between chromosomes 2 and 7, the cloning of the breakpoints at 7q21 revealed that each was located within a small region of DNA 3.6 kb upstream of the transcription start site of cyclin dependent kinase 6 (CDK6). In each case the translocation event was consistent with aberrant VJ recombination between the immunoglobulin light chain region (Ig kappa) on chromosome 2p12 and DNA sequences at 7q21, resembling the heptamer recombination site, The t(7;21) breakpoint in an additional patient with splenic marginal zone lymphoma (SMZL), resided 66 kb telomeric to the t(2;7) breakpoints juxtaposing CDK6 to an uncharacterized transcript. In two of the SLVL patient samples, the CDK6 protein was found to be markedly over expressed. These results suggest that dysregulation of CDK6 gene expression contributes to the pathogenesis of SLVL and SMZL.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subject7q translocationsen_HK
dc.subjectCDK6en_HK
dc.subjectSLVLen_HK
dc.subjectSMZLen_HK
dc.subject.meshCdk6en_HK
dc.subject.mesh7q translocationsen_HK
dc.subject.meshSmzlen_HK
dc.subject.meshSlvlen_HK
dc.subject.meshCyclin-dependent kinasesen_HK
dc.titleDysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=18&issue=46&spage=6271&epage=6277&date=1999&atitle=Dysregulation+of+cyclin+dependent+kinase+6+expression+in+splenic+marginal+zone+lymphoma+through+chromosome+7q+translocationsen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1038/sj.onc.1203033-
dc.identifier.pmid10597225-
dc.identifier.scopuseid_2-s2.0-0033523992en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033523992&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue46en_HK
dc.identifier.spage6271en_HK
dc.identifier.epage6277en_HK
dc.identifier.isiWOS:000083934100010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCorcoran, MM=7102551160en_HK
dc.identifier.scopusauthoridMould, SJ=6603176921en_HK
dc.identifier.scopusauthoridOrchard, JA=7006933405en_HK
dc.identifier.scopusauthoridIbbotson, RE=7005590857en_HK
dc.identifier.scopusauthoridChapman, RM=7403127841en_HK
dc.identifier.scopusauthoridBoright, AP=6603298498en_HK
dc.identifier.scopusauthoridPlatt, C=7006575437en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridOscier, DG=7005408586en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats