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Article: Genome scan for linkage to Gilles de la Tourette syndrome

TitleGenome scan for linkage to Gilles de la Tourette syndrome
Authors
KeywordsGenetics
Genome scan
Gilles de la Tourette syndrome
Linkage
Issue Date1999
PublisherJohn Wiley & Sons, Inc.
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 4, p. 437-445 How to Cite?
AbstractGilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Despite clear evidence for a genetic predisposition to TS from family, twin, and adoption studies, there have been no confirmed linkage findings. In this article we test for linkage to TS in multigenerational families segregating TS using a panel of 386 markers with the largest interval between any two markers being 28 cM and an average distance between markers of 10 cM. We tested for linkage using an autosomal dominant model with reduced penetrance and using nonparametric methods. No significant evidence for linkage was found with parametric analysis. A logarithm of the odds (LOD) score of greater or equal to one under the autosomal dominant model was observed in 24 of these markers in at least one of the families tested. No LOD scores greater than two were observed with any of the markers. For the nonparametric analysis, eight markers were observed with a P-value less than 0.00005 for significance evidence of linkage in at least one family. However caution should be used in the interpretation of the nonparametric analyses as this statistic (the affected-pedigree-member method) is know to have a high false-positive rate. Further support for linkage in these regions is required before linkage can be assumed.
Persistent Identifierhttp://hdl.handle.net/10722/44352
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarr, CLen_HK
dc.contributor.authorWigg, KGen_HK
dc.contributor.authorPakstis, AJen_HK
dc.contributor.authorKurlan, Ren_HK
dc.contributor.authorPauls, Den_HK
dc.contributor.authorKidd, KKen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorSandor, Pen_HK
dc.date.accessioned2007-09-12T03:51:57Z-
dc.date.available2007-09-12T03:51:57Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 4, p. 437-445en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44352-
dc.description.abstractGilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Despite clear evidence for a genetic predisposition to TS from family, twin, and adoption studies, there have been no confirmed linkage findings. In this article we test for linkage to TS in multigenerational families segregating TS using a panel of 386 markers with the largest interval between any two markers being 28 cM and an average distance between markers of 10 cM. We tested for linkage using an autosomal dominant model with reduced penetrance and using nonparametric methods. No significant evidence for linkage was found with parametric analysis. A logarithm of the odds (LOD) score of greater or equal to one under the autosomal dominant model was observed in 24 of these markers in at least one of the families tested. No LOD scores greater than two were observed with any of the markers. For the nonparametric analysis, eight markers were observed with a P-value less than 0.00005 for significance evidence of linkage in at least one family. However caution should be used in the interpretation of the nonparametric analyses as this statistic (the affected-pedigree-member method) is know to have a high false-positive rate. Further support for linkage in these regions is required before linkage can be assumed.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.subjectGeneticsen_HK
dc.subjectGenome scanen_HK
dc.subjectGilles de la Tourette syndromeen_HK
dc.subjectLinkageen_HK
dc.subject.meshGilles de la tourette syndromeen_HK
dc.subject.meshGeneticsen_HK
dc.subject.meshGenome scanen_HK
dc.subject.meshLinkageen_HK
dc.subject.meshLinkage (genetics)en_HK
dc.titleGenome scan for linkage to Gilles de la Tourette syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=88&issue=4&spage=437&epage=445&date=1999&atitle=Genome+scan+for+linkage+to+Gilles+de+la+Tourette+syndromeen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1002/(SICI)1096-8628(19990820)88:4<437::AID-AJMG24>3.0.CO;2-Een_HK
dc.identifier.pmid10402514-
dc.identifier.scopuseid_2-s2.0-0033588323en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033588323&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue4en_HK
dc.identifier.spage437en_HK
dc.identifier.epage445en_HK
dc.identifier.isiWOS:000081581400024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBarr, CL=35447356300en_HK
dc.identifier.scopusauthoridWigg, KG=6602896419en_HK
dc.identifier.scopusauthoridPakstis, AJ=7003963252en_HK
dc.identifier.scopusauthoridKurlan, R=19735255600en_HK
dc.identifier.scopusauthoridPauls, D=7007038603en_HK
dc.identifier.scopusauthoridKidd, KK=35292270000en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridSandor, P=7006004292en_HK

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