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Article: Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human

TitleCloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human
Authors
Issue Date1999
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1999, v. 55 n. 3, p. 257-267 How to Cite?
AbstractCytoplasmic dynein is a large multisubunit microtubule-based motor protein, which mediates movement of numerous intracellular organelles. We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS. A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human.
Persistent Identifierhttp://hdl.handle.net/10722/44349
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCrackower, MAen_HK
dc.contributor.authorSnasac, DSen_HK
dc.contributor.authorXia, Jen_HK
dc.contributor.authorMotoyama, Jen_HK
dc.contributor.authorProchazka, Men_HK
dc.contributor.authorRommens, JMen_HK
dc.contributor.authorSbherer, SWen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:51:53Z-
dc.date.available2007-09-12T03:51:53Z-
dc.date.issued1999en_HK
dc.identifier.citationGenomics, 1999, v. 55 n. 3, p. 257-267en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44349-
dc.description.abstractCytoplasmic dynein is a large multisubunit microtubule-based motor protein, which mediates movement of numerous intracellular organelles. We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS. A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshDynein atpase - genetics - metabolism - physiologyen_HK
dc.subject.meshTissue distributionen_HK
dc.subject.meshLimb bud - metabolismen_HK
dc.subject.meshEmbryonic and fetal developmenten_HK
dc.subject.meshSequence homology, amino aciden_HK
dc.titleCloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and humanen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=55&issue=3&spage=257&epage=267&date=1999&atitle=Cloning+and+characterization+of+two+cytoplasmic+dynein+intermediate+chain+genes+in+mouse+and+humanen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1998.5665en_HK
dc.identifier.pmid10049579-
dc.identifier.scopuseid_2-s2.0-0033083051en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033083051&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue3en_HK
dc.identifier.spage257en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000078771400001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCrackower, MA=6701530321en_HK
dc.identifier.scopusauthoridSnasac, DS=7801388288en_HK
dc.identifier.scopusauthoridXia, J=36930606800en_HK
dc.identifier.scopusauthoridMotoyama, J=6701556287en_HK
dc.identifier.scopusauthoridProchazka, M=7102572739en_HK
dc.identifier.scopusauthoridRommens, JM=7006884140en_HK
dc.identifier.scopusauthoridSbherer, SW=35381313100en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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