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Article: Heterogeneity of reproductive tract abnormalities in men with absence of the vas deferens: Role of cystic fibrosis transmembrane conductance regulator gene mutations

TitleHeterogeneity of reproductive tract abnormalities in men with absence of the vas deferens: Role of cystic fibrosis transmembrane conductance regulator gene mutations
Authors
KeywordsCystic fibrosis transmembrane conductance regulator
Male infertility
Testicular microlithiasis
Vas deferens
Wolffian duct
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 1998, v. 70 n. 4, p. 724-728 How to Cite?
AbstractObjective: To determine if the types of reproductive tract abnormalities linked to absence of the vas deferens varies with the cystic fibrosis transmembrane conductance regulator (CFTR) genotype. Design: Prospective data gathering. Setting: University infertility clinic. Patient(s): Forty-six infertile men with absence of the scrotal vas deferens and no signs of cystic fibrosis. Intervention(s): All had blood taken for CFTR gene analysis, 33 had scrotal ultrasounds, and 25 had transrectal ultrasounds. Main Outcome Measure(s): The frequency of testicular, seminal vesicle, and ampullae of the vas deferens malformations was compared between subgroups of men with two, one, or no CFTR gene mutations. Result(s): None (0 of 21) of the men with at least one CFTR gene mutations had normal ampullae of the vas or seminal vesicles bilaterally. Two (50%) of 4 men with no CFTR gene mutations had normal ampullae of the vas deferens bilaterally, and 50% had normal bilateral seminal vesicles (statistically significantly different). There was no correlation between testicular malformations and CFTR genotype. Conclusion(s): This study indicates that the severity of the malformations in the testis is unrelated to the CFTR genotype, whereas the frequency and severity of wolffian duct malformations are related directly to the CFTR genotype.
Persistent Identifierhttp://hdl.handle.net/10722/44348
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJarvi, Ken_HK
dc.contributor.authorMcCallum, Sen_HK
dc.contributor.authorZielenski, Jen_HK
dc.contributor.authorDurie, Pen_HK
dc.contributor.authorTullis, Een_HK
dc.contributor.authorWilchanski, Men_HK
dc.contributor.authorMargolis, Men_HK
dc.contributor.authorAsch, Men_HK
dc.contributor.authorGinzburg, Ben_HK
dc.contributor.authorMartin, Sen_HK
dc.contributor.authorBuckspan, MBen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:51:52Z-
dc.date.available2007-09-12T03:51:52Z-
dc.date.issued1998en_HK
dc.identifier.citationFertility And Sterility, 1998, v. 70 n. 4, p. 724-728en_HK
dc.identifier.issn0015-0282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44348-
dc.description.abstractObjective: To determine if the types of reproductive tract abnormalities linked to absence of the vas deferens varies with the cystic fibrosis transmembrane conductance regulator (CFTR) genotype. Design: Prospective data gathering. Setting: University infertility clinic. Patient(s): Forty-six infertile men with absence of the scrotal vas deferens and no signs of cystic fibrosis. Intervention(s): All had blood taken for CFTR gene analysis, 33 had scrotal ultrasounds, and 25 had transrectal ultrasounds. Main Outcome Measure(s): The frequency of testicular, seminal vesicle, and ampullae of the vas deferens malformations was compared between subgroups of men with two, one, or no CFTR gene mutations. Result(s): None (0 of 21) of the men with at least one CFTR gene mutations had normal ampullae of the vas or seminal vesicles bilaterally. Two (50%) of 4 men with no CFTR gene mutations had normal ampullae of the vas deferens bilaterally, and 50% had normal bilateral seminal vesicles (statistically significantly different). There was no correlation between testicular malformations and CFTR genotype. Conclusion(s): This study indicates that the severity of the malformations in the testis is unrelated to the CFTR genotype, whereas the frequency and severity of wolffian duct malformations are related directly to the CFTR genotype.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_HK
dc.relation.ispartofFertility and Sterilityen_HK
dc.subjectCystic fibrosis transmembrane conductance regulatoren_HK
dc.subjectMale infertilityen_HK
dc.subjectTesticular microlithiasisen_HK
dc.subjectVas deferensen_HK
dc.subjectWolffian ducten_HK
dc.subject.meshMale infertilityen_HK
dc.subject.meshVas deferensen_HK
dc.subject.meshWolffian ducten_HK
dc.subject.meshYstic fibrosis transmembrane conductance regulatoren_HK
dc.subject.meshTesticular microlithiasisen_HK
dc.titleHeterogeneity of reproductive tract abnormalities in men with absence of the vas deferens: Role of cystic fibrosis transmembrane conductance regulator gene mutationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0015-0282&volume=70&issue=4&spage=724&epage=728&date=1999&atitle=Heterogeneity+of+reproductive+tract+abnormalities+in+men+with+absence+of+the+vas+deferens:+role+of+cystic+fibrosis+transmembrane+conductance+regulator+gene+mutationsen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/S0015-0282(98)00247-7en_HK
dc.identifier.pmid9797105-
dc.identifier.scopuseid_2-s2.0-0031722993en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031722993&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue4en_HK
dc.identifier.spage724en_HK
dc.identifier.epage728en_HK
dc.identifier.isiWOS:000076505400020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJarvi, K=23392788300en_HK
dc.identifier.scopusauthoridMcCallum, S=7007104727en_HK
dc.identifier.scopusauthoridZielenski, J=7003732699en_HK
dc.identifier.scopusauthoridDurie, P=7005360997en_HK
dc.identifier.scopusauthoridTullis, E=6602749234en_HK
dc.identifier.scopusauthoridWilchanski, M=6504021422en_HK
dc.identifier.scopusauthoridMargolis, M=7101753534en_HK
dc.identifier.scopusauthoridAsch, M=7007065024en_HK
dc.identifier.scopusauthoridGinzburg, B=7102439417en_HK
dc.identifier.scopusauthoridMartin, S=35611051800en_HK
dc.identifier.scopusauthoridBuckspan, MB=6602082010en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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