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Article: Human PON2 gene at 7q21.3: Cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence

TitleHuman PON2 gene at 7q21.3: Cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence
Authors
Mochizuki, HScherer, SWXi, TNickle, DCMajer, MHuizenga, JJTsui, LCProchazka, M
KeywordsAlternative splicing
Amino acid variants
Exon-intron structure
Paraoxonase-2
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 1998, v. 213 n. 1-2, p. 149-157 How to Cite?
DOI: http://dx.doi.org/10.1016/S0378-1119(98)00193-0
AbstractWe report the cloning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked with PON1 and PON3 on 7q21.3. PON2 is ubiquitously expressed and we identified several mRNA forms produced by alternative splicing, or by the use of a second transcription start site. We also describe two polymorphisms in the coding sequences that, in the protein deduced from the longest open reading frame, predict an alanine-to-glycine substitution at residue 147 and a serine-to-cysteine substitution at residue 310.
Persistent Identifierhttp://hdl.handle.net/10722/44346
ISSN
0378-1119
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.725
ISI Accession Number ID
WOS:000074481000019
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMochizuki, Hen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorXi, Ten_HK
dc.contributor.authorNickle, DCen_HK
dc.contributor.authorMajer, Men_HK
dc.contributor.authorHuizenga, JJen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorProchazka, Men_HK
dc.date.accessioned2007-09-12T03:51:50Z-
dc.date.available2007-09-12T03:51:50Z-
dc.date.issued1998en_HK
dc.identifier.citationGene, 1998, v. 213 n. 1-2, p. 149-157en_HK
dc.identifier.issn0378-1119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44346-
dc.description.abstractWe report the cloning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked with PON1 and PON3 on 7q21.3. PON2 is ubiquitously expressed and we identified several mRNA forms produced by alternative splicing, or by the use of a second transcription start site. We also describe two polymorphisms in the coding sequences that, in the protein deduced from the longest open reading frame, predict an alanine-to-glycine substitution at residue 147 and a serine-to-cysteine substitution at residue 310.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/geneen_HK
dc.relation.ispartofGeneen_HK
dc.subjectAlternative splicingen_HK
dc.subjectAmino acid variantsen_HK
dc.subjectExon-intron structureen_HK
dc.subjectParaoxonase-2en_HK
dc.subject.meshParaoxonase-2en_HK
dc.subject.meshExon–intron structureen_HK
dc.subject.meshAlternative splicingen_HK
dc.subject.meshAmino acid variantsen_HK
dc.subject.meshEsterases - biosynthesis - geneticsen_HK
dc.titleHuman PON2 gene at 7q21.3: Cloning, multiple mRNA forms, and missense polymorphisms in the coding sequenceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-1119&volume=213&issue=1-2&spage=149&epage=157&date=1998&atitle=Human+PON2+gene+at+7q21.3:+cloning,+multiple+mRNA+forms,+and+missense+polymorphisms+in+the+coding+sequenceen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/S0378-1119(98)00193-0en_HK
dc.identifier.pmid9714608-
dc.identifier.scopuseid_2-s2.0-0032526104en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032526104&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume213en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage149en_HK
dc.identifier.epage157en_HK
dc.identifier.isiWOS:000074481000019-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMochizuki, H=7202006117en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridXi, T=36889083500en_HK
dc.identifier.scopusauthoridNickle, DC=6603553175en_HK
dc.identifier.scopusauthoridMajer, M=36819915400en_HK
dc.identifier.scopusauthoridHuizenga, JJ=7005960086en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridProchazka, M=7102572739en_HK
dc.identifier.issnl0378-1119-

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