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Article: Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis

TitleOverlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis
Authors
KeywordsAdult tissue
Eyelid
Intestine
Lung
Mouse embryo
Nasal epithelium
Nasal gland
Neural tube
Ptch
Ptch2
Shh
Stomach
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modo
Citation
Mechanisms Of Development, 1998, v. 78 n. 1-2, p. 81-84 How to Cite?
AbstractIn Drosophila, patched encodes a negative regulator of Hedgehog signaling. Biochemical experiments have demonstrated that vertebrate patched homologues might function as a Sonic hedgehog (Shh) receptor. In mice, two patched homologues, Ptch and Ptch2, have been identified. Sequence comparison have suggested that they might possess distinct properties in Shh signaling. In the developing tooth, hair and whisker, Shh and Ptch2 are co-expressed in the epithelium while Ptch is strongly expressed in the mesenchymal cells. We report here the chromosomal localization of Ptch2 and further analysis of Ptch2 expression. Throughout mouse development, the level of Ptch2 expression is significantly lower than that of Ptch. In early mouse embryos, Ptch and Ptch2 were found to be co-expressed in regions adjacent to Shh-expressing cells in the developing CNS. Similar to other epidermal structures, Shh and Ptch2 also show overlapping expression in the developing nasal gland and eyelids. Thus, during mouse development, Ptch2 is expressed in both Shh- producing and nonproducing cells.
Persistent Identifierhttp://hdl.handle.net/10722/44345
ISSN
2015 Impact Factor: 2.041
2015 SCImago Journal Rankings: 1.368
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMotoyama, Jen_HK
dc.contributor.authorHeng, Hen_HK
dc.contributor.authorCrackower, MAen_HK
dc.contributor.authorTakabatake, Ten_HK
dc.contributor.authorTakeshima, Ken_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorHui, CCen_HK
dc.date.accessioned2007-09-12T03:51:49Z-
dc.date.available2007-09-12T03:51:49Z-
dc.date.issued1998en_HK
dc.identifier.citationMechanisms Of Development, 1998, v. 78 n. 1-2, p. 81-84en_HK
dc.identifier.issn0925-4773en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44345-
dc.description.abstractIn Drosophila, patched encodes a negative regulator of Hedgehog signaling. Biochemical experiments have demonstrated that vertebrate patched homologues might function as a Sonic hedgehog (Shh) receptor. In mice, two patched homologues, Ptch and Ptch2, have been identified. Sequence comparison have suggested that they might possess distinct properties in Shh signaling. In the developing tooth, hair and whisker, Shh and Ptch2 are co-expressed in the epithelium while Ptch is strongly expressed in the mesenchymal cells. We report here the chromosomal localization of Ptch2 and further analysis of Ptch2 expression. Throughout mouse development, the level of Ptch2 expression is significantly lower than that of Ptch. In early mouse embryos, Ptch and Ptch2 were found to be co-expressed in regions adjacent to Shh-expressing cells in the developing CNS. Similar to other epidermal structures, Shh and Ptch2 also show overlapping expression in the developing nasal gland and eyelids. Thus, during mouse development, Ptch2 is expressed in both Shh- producing and nonproducing cells.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modoen_HK
dc.relation.ispartofMechanisms of Developmenten_HK
dc.subjectAdult tissueen_HK
dc.subjectEyeliden_HK
dc.subjectIntestineen_HK
dc.subjectLungen_HK
dc.subjectMouse embryoen_HK
dc.subjectNasal epitheliumen_HK
dc.subjectNasal glanden_HK
dc.subjectNeural tubeen_HK
dc.subjectPtchen_HK
dc.subjectPtch2en_HK
dc.subjectShhen_HK
dc.subjectStomachen_HK
dc.subject.meshMouse embryoen_HK
dc.subject.meshAdult tissueen_HK
dc.subject.meshNeural tubeen_HK
dc.subject.meshNasal epitheliumen_HK
dc.subject.meshNasal glanden_HK
dc.titleOverlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-4773&volume=78&issue=1-2&spage=81&epage=84&date=1998&atitle=Overlapping+and+non-overlapping+Ptch2+expression+with+Shh+during+mouse+embryogenesisen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/S0925-4773(98)00149-Xen_HK
dc.identifier.pmid9858693-
dc.identifier.scopuseid_2-s2.0-0031647943en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031647943&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage81en_HK
dc.identifier.epage84en_HK
dc.identifier.isiWOS:000077724000007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridMotoyama, J=6701556287en_HK
dc.identifier.scopusauthoridHeng, H=7005338076en_HK
dc.identifier.scopusauthoridCrackower, MA=6701530321en_HK
dc.identifier.scopusauthoridTakabatake, T=7101600377en_HK
dc.identifier.scopusauthoridTakeshima, K=7006875146en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridHui, CC=7202876913en_HK

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