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Article: Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites

TitleGenetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites
Authors
KeywordsAlberta Hutterites
Genetic variation
Paraoxonase-1
Paraoxonase-2
Plasma lipoproteins
PON1
PON2
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 1998, v. 139 n. 1, p. 131-136 How to Cite?
Abstract
In a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic variation in PON2 and variation in plasma quantitative traits variation in a sample of 745 Alberta Hutterites. We found novel genetic associations between PON2 variation and variation in fasting plasma concentrations of total cholesterol and apolipoprotein AI. We confirmed our previously observed significant associations in this study sample between PON1 genetic variation and variation in plasma apo B-related traits, such as LDL, non-HDL and HDL cholesterol and apo B itself. Furthermore, there was almost complete linkage disequilibrium between PON2 alleles G148 and C311. We found no association between PON2 variation and plasma glucose or insulin. Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in both PON1 and PON2 that affects the amino acid sequence of the respective gene products is associated with significant variation in intermediate traits in plasma lipoprotein metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/44342
ISSN
2013 Impact Factor: 3.971
2013 SCImago Journal Rankings: 1.728
ISI Accession Number ID
References

 

Author Affiliations
  1. Saint Michael's Hospital University of Toronto
  2. Western University
  3. University of Victoria
  4. Hospital for Sick Children University of Toronto
DC FieldValueLanguage
dc.contributor.authorBoright, APen_HK
dc.contributor.authorConnelly, PWen_HK
dc.contributor.authorBrunt, JHen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorHegele, RAen_HK
dc.date.accessioned2007-09-12T03:51:46Z-
dc.date.available2007-09-12T03:51:46Z-
dc.date.issued1998en_HK
dc.identifier.citationAtherosclerosis, 1998, v. 139 n. 1, p. 131-136en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44342-
dc.description.abstractIn a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic variation in PON2 and variation in plasma quantitative traits variation in a sample of 745 Alberta Hutterites. We found novel genetic associations between PON2 variation and variation in fasting plasma concentrations of total cholesterol and apolipoprotein AI. We confirmed our previously observed significant associations in this study sample between PON1 genetic variation and variation in plasma apo B-related traits, such as LDL, non-HDL and HDL cholesterol and apo B itself. Furthermore, there was almost complete linkage disequilibrium between PON2 alleles G148 and C311. We found no association between PON2 variation and plasma glucose or insulin. Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in both PON1 and PON2 that affects the amino acid sequence of the respective gene products is associated with significant variation in intermediate traits in plasma lipoprotein metabolism.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.subjectAlberta Hutteritesen_HK
dc.subjectGenetic variationen_HK
dc.subjectParaoxonase-1en_HK
dc.subjectParaoxonase-2en_HK
dc.subjectPlasma lipoproteinsen_HK
dc.subjectPON1en_HK
dc.subjectPON2en_HK
dc.subject.meshGenetic variationen_HK
dc.subject.meshParaoxonase-1en_HK
dc.subject.meshParaoxonase-2en_HK
dc.subject.meshPlasma lipoproteinsen_HK
dc.subject.meshAlberta hutteritesen_HK
dc.titleGenetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutteritesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=139&issue=1&spage=131&epage=136&date=1998&atitle=Genetic+variation+in+paraoxonase-1+and+paraoxonase-2+is+associated+with+variation+in+plasma+lipoproteins+in+Alberta+Hutteritesen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.natureabstracten_HK
dc.identifier.doi10.1016/S0021-9150(98)00071-9en_HK
dc.identifier.pmid9699900en_HK
dc.identifier.scopuseid_2-s2.0-0032127075en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032127075&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume139en_HK
dc.identifier.issue1en_HK
dc.identifier.spage131en_HK
dc.identifier.epage136en_HK
dc.identifier.isiWOS:000074981400015-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridBoright, AP=6603298498en_HK
dc.identifier.scopusauthoridConnelly, PW=16738577100en_HK
dc.identifier.scopusauthoridBrunt, JH=7006565892en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridHegele, RA=35399481100en_HK

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