File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites
  • Basic View
  • Metadata View
  • XML View
TitleGenetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites
 
AuthorsBoright, AP1
Connelly, PW1 1
Brunt, JH3
Scherer, SW4
Tsui, LC4
Hegele, RA2
 
KeywordsAlberta Hutterites
Genetic variation
Paraoxonase-1
Paraoxonase-2
Plasma lipoproteins
PON1
PON2
 
Issue Date1998
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
 
CitationAtherosclerosis, 1998, v. 139 n. 1, p. 131-136 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0021-9150(98)00071-9
 
AbstractIn a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic variation in PON2 and variation in plasma quantitative traits variation in a sample of 745 Alberta Hutterites. We found novel genetic associations between PON2 variation and variation in fasting plasma concentrations of total cholesterol and apolipoprotein AI. We confirmed our previously observed significant associations in this study sample between PON1 genetic variation and variation in plasma apo B-related traits, such as LDL, non-HDL and HDL cholesterol and apo B itself. Furthermore, there was almost complete linkage disequilibrium between PON2 alleles G148 and C311. We found no association between PON2 variation and plasma glucose or insulin. Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in both PON1 and PON2 that affects the amino acid sequence of the respective gene products is associated with significant variation in intermediate traits in plasma lipoprotein metabolism.
 
ISSN0021-9150
2012 Impact Factor: 3.706
2012 SCImago Journal Rankings: 1.388
 
DOIhttp://dx.doi.org/10.1016/S0021-9150(98)00071-9
 
ISI Accession Number IDWOS:000074981400015
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBoright, AP
 
dc.contributor.authorConnelly, PW
 
dc.contributor.authorBrunt, JH
 
dc.contributor.authorScherer, SW
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorHegele, RA
 
dc.date.accessioned2007-09-12T03:51:46Z
 
dc.date.available2007-09-12T03:51:46Z
 
dc.date.issued1998
 
dc.description.abstractIn a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic variation in PON2 and variation in plasma quantitative traits variation in a sample of 745 Alberta Hutterites. We found novel genetic associations between PON2 variation and variation in fasting plasma concentrations of total cholesterol and apolipoprotein AI. We confirmed our previously observed significant associations in this study sample between PON1 genetic variation and variation in plasma apo B-related traits, such as LDL, non-HDL and HDL cholesterol and apo B itself. Furthermore, there was almost complete linkage disequilibrium between PON2 alleles G148 and C311. We found no association between PON2 variation and plasma glucose or insulin. Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in both PON1 and PON2 that affects the amino acid sequence of the respective gene products is associated with significant variation in intermediate traits in plasma lipoprotein metabolism.
 
dc.description.natureabstract
 
dc.identifier.citationAtherosclerosis, 1998, v. 139 n. 1, p. 131-136 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0021-9150(98)00071-9
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0021-9150(98)00071-9
 
dc.identifier.epage136
 
dc.identifier.isiWOS:000074981400015
 
dc.identifier.issn0021-9150
2012 Impact Factor: 3.706
2012 SCImago Journal Rankings: 1.388
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid9699900
 
dc.identifier.scopuseid_2-s2.0-0032127075
 
dc.identifier.spage131
 
dc.identifier.urihttp://hdl.handle.net/10722/44342
 
dc.identifier.volume139
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
 
dc.publisher.placeIreland
 
dc.relation.ispartofAtherosclerosis
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshGenetic variation
 
dc.subject.meshParaoxonase-1
 
dc.subject.meshParaoxonase-2
 
dc.subject.meshPlasma lipoproteins
 
dc.subject.meshAlberta hutterites
 
dc.subjectAlberta Hutterites
 
dc.subjectGenetic variation
 
dc.subjectParaoxonase-1
 
dc.subjectParaoxonase-2
 
dc.subjectPlasma lipoproteins
 
dc.subjectPON1
 
dc.subjectPON2
 
dc.titleGenetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Boright, AP</contributor.author>
<contributor.author>Connelly, PW</contributor.author>
<contributor.author>Brunt, JH</contributor.author>
<contributor.author>Scherer, SW</contributor.author>
<contributor.author>Tsui, LC</contributor.author>
<contributor.author>Hegele, RA</contributor.author>
<date.accessioned>2007-09-12T03:51:46Z</date.accessioned>
<date.available>2007-09-12T03:51:46Z</date.available>
<date.issued>1998</date.issued>
<identifier.citation>Atherosclerosis, 1998, v. 139 n. 1, p. 131-136</identifier.citation>
<identifier.issn>0021-9150</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/44342</identifier.uri>
<description.abstract>In a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic variation in PON2 and variation in plasma quantitative traits variation in a sample of 745 Alberta Hutterites. We found novel genetic associations between PON2 variation and variation in fasting plasma concentrations of total cholesterol and apolipoprotein AI. We confirmed our previously observed significant associations in this study sample between PON1 genetic variation and variation in plasma apo B-related traits, such as LDL, non-HDL and HDL cholesterol and apo B itself. Furthermore, there was almost complete linkage disequilibrium between PON2 alleles G148 and C311. We found no association between PON2 variation and plasma glucose or insulin. Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in both PON1 and PON2 that affects the amino acid sequence of the respective gene products is associated with significant variation in intermediate traits in plasma lipoprotein metabolism.</description.abstract>
<language>eng</language>
<publisher>Elsevier Ireland Ltd. The Journal&apos;s web site is located at http://www.elsevier.com/locate/atherosclerosis</publisher>
<relation.ispartof>Atherosclerosis</relation.ispartof>
<subject>Alberta Hutterites</subject>
<subject>Genetic variation</subject>
<subject>Paraoxonase-1</subject>
<subject>Paraoxonase-2</subject>
<subject>Plasma lipoproteins</subject>
<subject>PON1</subject>
<subject>PON2</subject>
<subject.mesh>Genetic variation</subject.mesh>
<subject.mesh>Paraoxonase-1</subject.mesh>
<subject.mesh>Paraoxonase-2</subject.mesh>
<subject.mesh>Plasma lipoproteins</subject.mesh>
<subject.mesh>Alberta hutterites</subject.mesh>
<title>Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0021-9150&amp;volume=139&amp;issue=1&amp;spage=131&amp;epage=136&amp;date=1998&amp;atitle=Genetic+variation+in+paraoxonase-1+and+paraoxonase-2+is+associated+with+variation+in+plasma+lipoproteins+in+Alberta+Hutterites</identifier.openurl>
<description.nature>abstract</description.nature>
<identifier.doi>10.1016/S0021-9150(98)00071-9</identifier.doi>
<identifier.pmid>9699900</identifier.pmid>
<identifier.scopus>eid_2-s2.0-0032127075</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032127075&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>139</identifier.volume>
<identifier.issue>1</identifier.issue>
<identifier.spage>131</identifier.spage>
<identifier.epage>136</identifier.epage>
<identifier.isi>WOS:000074981400015</identifier.isi>
<publisher.place>Ireland</publisher.place>
</item>
Author Affiliations
  1. Saint Michael's Hospital University of Toronto
  2. Western University
  3. University of Victoria
  4. Hospital for Sick Children University of Toronto