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Article: Gene structure of the human MET proto-oncogene

TitleGene structure of the human MET proto-oncogene
Authors
KeywordsHGF/SF receptor
MET proto-oncogene
Renal carcinoma
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1997, v. 15 n. 13, p. 1583-1586 How to Cite?
AbstractBy direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one additional exon. These 20 exons, together with a previously reported exon, bring the total exon number of MET to 21. Oligonucleotide primers were designed to amplify each exon and adjacent intronic sequences to permit examination of each exon for mutations. By restriction mapping, we assembled a 110 kb genomic contig that covered almost the entire MET protooncogene. This information is relevant for the screening of recently reported mutations of the MET gene which cause hereditary papillary renal carcinomas and for the search for additional mutations of the same gene which may play a role in the pathogenesis of common human carcinomas including carcinomas of the breast, ovary and pancreas.
Persistent Identifierhttp://hdl.handle.net/10722/44328
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuh, FMen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorLerman, MIen_HK
dc.contributor.authorZbar, Ben_HK
dc.contributor.authorSchmidt, Len_HK
dc.date.accessioned2007-09-12T03:51:29Z-
dc.date.available2007-09-12T03:51:29Z-
dc.date.issued1997en_HK
dc.identifier.citationOncogene, 1997, v. 15 n. 13, p. 1583-1586en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44328-
dc.description.abstractBy direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one additional exon. These 20 exons, together with a previously reported exon, bring the total exon number of MET to 21. Oligonucleotide primers were designed to amplify each exon and adjacent intronic sequences to permit examination of each exon for mutations. By restriction mapping, we assembled a 110 kb genomic contig that covered almost the entire MET protooncogene. This information is relevant for the screening of recently reported mutations of the MET gene which cause hereditary papillary renal carcinomas and for the search for additional mutations of the same gene which may play a role in the pathogenesis of common human carcinomas including carcinomas of the breast, ovary and pancreas.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectHGF/SF receptoren_HK
dc.subjectMET proto-oncogeneen_HK
dc.subjectRenal carcinomaen_HK
dc.subject.meshProto-oncogene proteins c-meten_HK
dc.subject.meshProto-oncogenesen_HK
dc.subject.meshReceptor protein-tyrosine kinases - geneticsen_HK
dc.subject.meshMolecular sequence dataen_HK
dc.subject.meshMutationen_HK
dc.titleGene structure of the human MET proto-oncogeneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=15&issue=13&spage=1583&epage=1586&date=1997&atitle=Gene+structure+of+the+human+MET+proto-oncogeneen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1038/sj.onc.1201338-
dc.identifier.pmid9380410-
dc.identifier.scopuseid_2-s2.0-0030699255en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030699255&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue13en_HK
dc.identifier.spage1583en_HK
dc.identifier.epage1586en_HK
dc.identifier.isiWOS:A1997XX36900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridDuh, FM=7004146642en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridLerman, MI=24356375900en_HK
dc.identifier.scopusauthoridZbar, B=7102209278en_HK
dc.identifier.scopusauthoridSchmidt, L=7401563940en_HK

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