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Article: The human metabotropic glutamate receptor 8 (GRM8) gene: A disproportionately large gene located at 7q31.3-q32.1

TitleThe human metabotropic glutamate receptor 8 (GRM8) gene: A disproportionately large gene located at 7q31.3-q32.1
Authors
Issue Date1997
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1997, v. 44 n. 2, p. 232-236 How to Cite?
AbstractMetabotropic glutamate receptors (GRMs), which constitute a family of genes, are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Pharmacological and expression studies of the rodent Grm8 gene suggest it could be a presynaptic receptor modulating glutamate release at the axon terminals. To study human GRM8, we have determined its nucleotide sequence and genomic organization. While the coding region of the gene spans only 2.3 kb, the gene encompasses approximately 1000 kb of DNA at the boundary of the q31.3-q32.1 bands of chromosome 7. This observation is relevant to the study of Smith-Lemli-Opitz syndrome and an autosomal dominant form of retinitis pigmentosa (RP10), since they map to the same region.
Persistent Identifierhttp://hdl.handle.net/10722/44320
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorSoder, Sen_HK
dc.contributor.authorDuvoisin, RMen_HK
dc.contributor.authorHuizenga, JJen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:51:20Z-
dc.date.available2007-09-12T03:51:20Z-
dc.date.issued1997en_HK
dc.identifier.citationGenomics, 1997, v. 44 n. 2, p. 232-236en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44320-
dc.description.abstractMetabotropic glutamate receptors (GRMs), which constitute a family of genes, are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Pharmacological and expression studies of the rodent Grm8 gene suggest it could be a presynaptic receptor modulating glutamate release at the axon terminals. To study human GRM8, we have determined its nucleotide sequence and genomic organization. While the coding region of the gene spans only 2.3 kb, the gene encompasses approximately 1000 kb of DNA at the boundary of the q31.3-q32.1 bands of chromosome 7. This observation is relevant to the study of Smith-Lemli-Opitz syndrome and an autosomal dominant form of retinitis pigmentosa (RP10), since they map to the same region.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshChromosomes, human, pair 7 - geneticsen_HK
dc.subject.meshDna, complementary - geneticsen_HK
dc.subject.meshReceptors, metabotropic glutamate - geneticsen_HK
dc.subject.meshSmith-lemli-opitz syndrome - geneticsen_HK
dc.subject.meshGenetic markersen_HK
dc.titleThe human metabotropic glutamate receptor 8 (GRM8) gene: A disproportionately large gene located at 7q31.3-q32.1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=44&issue=2&spage=232&epage=236&date=1997&atitle=The+human+metabotropic+glutamate+receptor+8+(GRM8)+gene:+a+disproportionately+large+gene+located+at+7q31.3-q32.1+en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1997.4842en_HK
dc.identifier.pmid9299241-
dc.identifier.scopuseid_2-s2.0-0031238650en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031238650&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue2en_HK
dc.identifier.spage232en_HK
dc.identifier.epage236en_HK
dc.identifier.isiWOS:A1997XY07700011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridSoder, S=6602121375en_HK
dc.identifier.scopusauthoridDuvoisin, RM=7004387475en_HK
dc.identifier.scopusauthoridHuizenga, JJ=7005960086en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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