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Article: Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene

TitleExpression analysis and chromosomal assignment of the human SFRS5/SRp40 gene
Authors
Issue Date1997
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1997, v. 43 n. 2, p. 165-170 How to Cite?
AbstractAlternative splicing plays a major role in the regulation of gene expression. SFRS5/SRp40 is a member of the serine/arginine (SR) protein family of regulators of alternative pre-mRNA splicing. We cloned the human SFRS5 cDNA and observed two major SFRS5 transcripts, an ~1.8-kb short form and an ~3.3-kb long form, in both human and rat tissues. Both transcripts were detected in all human tissues examined, but there were notable tissue- specific differences in their relative abundance, the short form being most abundant in retina. Affinity-purified SFRS5 antisera recognized a single 40- kDa polypeptide in human and mouse retinal lysates. The abundant retinal expression of SFRS5 was not restricted to any specific cell type, since immunofluorescent labeling of human retinal sections identified the SFRS5 protein in nuclei of all three nuclear layers of the retina. The human SFRS5 gene was localized to human chromosome 14q24 by fluorescence in situ hybridization and PCR analysis of a human/hamster somatic cell hybrid panel.
Persistent Identifierhttp://hdl.handle.net/10722/44319
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSnow, BEen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorDu, Ken_HK
dc.contributor.authorTaub, Ren_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorMcInnes, RRen_HK
dc.date.accessioned2007-09-12T03:51:19Z-
dc.date.available2007-09-12T03:51:19Z-
dc.date.issued1997en_HK
dc.identifier.citationGenomics, 1997, v. 43 n. 2, p. 165-170en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44319-
dc.description.abstractAlternative splicing plays a major role in the regulation of gene expression. SFRS5/SRp40 is a member of the serine/arginine (SR) protein family of regulators of alternative pre-mRNA splicing. We cloned the human SFRS5 cDNA and observed two major SFRS5 transcripts, an ~1.8-kb short form and an ~3.3-kb long form, in both human and rat tissues. Both transcripts were detected in all human tissues examined, but there were notable tissue- specific differences in their relative abundance, the short form being most abundant in retina. Affinity-purified SFRS5 antisera recognized a single 40- kDa polypeptide in human and mouse retinal lysates. The abundant retinal expression of SFRS5 was not restricted to any specific cell type, since immunofluorescent labeling of human retinal sections identified the SFRS5 protein in nuclei of all three nuclear layers of the retina. The human SFRS5 gene was localized to human chromosome 14q24 by fluorescence in situ hybridization and PCR analysis of a human/hamster somatic cell hybrid panel.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshChromosome mappingen_HK
dc.subject.meshChromosomes, human, pair 14 - geneticsen_HK
dc.subject.meshGene expression regulation - geneticsen_HK
dc.subject.meshNuclear proteins - analysis - geneticsen_HK
dc.subject.meshPhosphoproteins - analysis - geneticsen_HK
dc.titleExpression analysis and chromosomal assignment of the human SFRS5/SRp40 geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=43&issue=2&spage=165&epage=170&date=1997&atitle=Expression+analysis+and+chromosomal+assignment+of+the+human+SFRS5/SRp40+geneen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1997.4794en_HK
dc.identifier.pmid9244433-
dc.identifier.scopuseid_2-s2.0-0031571123en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031571123&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue2en_HK
dc.identifier.spage165en_HK
dc.identifier.epage170en_HK
dc.identifier.isiWOS:A1997XN41300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSnow, BE=7101600914en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridShi, XM=7402953863en_HK
dc.identifier.scopusauthoridZhou, Y=7405368195en_HK
dc.identifier.scopusauthoridDu, K=7004936400en_HK
dc.identifier.scopusauthoridTaub, R=7103300569en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridMcInnes, RR=7006946516en_HK

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