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Article: Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas

TitleLoss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas
Authors
KeywordsChromosome 7q22
CUTL1
Human Cut homeobox gene
Loss of heterozygosity
Tumor suppressor gene
Uterine leiomyoma
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1997, v. 14 n. 19, p. 2355-2365 How to Cite?
AbstractCytogenetic analyses has revealed deletions and/or rearrangments at several chromosomal positions in approximately half of uterine leiomyomas. The most frequent genetic alteration, deletion of 7q22, was found in approximately 35% of studied cases with cytogenetic abnormalities (128/366 = 35%). The same chromosomal band was also found to be deleted in a fraction of acute myeloid leukemias and myelodysplastic syndromes. The frequent deletion of 7q22 in some tumors suggest that a tumor suppressor gene may be located in this region. The human Cut-like homeobox gene, CUTL1, is one of the genes localized to 7q22 and it was shown previously to encode a transcriptional repressor that down-modulates the expression of c-Myc. Activation of the c-Myc oncogenic potential has been shown in many cancers to result from alterations in one or the other of its several mechanisms of regulation. These observations led us to hypothesize that CUTL1 could act as a tumor suppressor gene. In the present study, we have identified polymorphic markers within and directly adjacent to CUTL1 at 7q22 and demonstrated that these markers are present in a commonly deleted region in seven out of 50 uterine leiomyomas samples examined. Furthermore, Northern blot analysis revealed that CUTL1 mRNA levels were reduced in eight tumors out of 13. These results suggest that CUTL1 may act as a tumor suppressor gene whose inactivation could be of pathological importance in the etiology of uterine leiomyomas.
Persistent Identifierhttp://hdl.handle.net/10722/44317
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZeng, WRen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorKoutsilieris, Men_HK
dc.contributor.authorHuizenga, JJen_HK
dc.contributor.authorFilteau, Fen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorNepveu, Aen_HK
dc.date.accessioned2007-09-12T03:51:17Z-
dc.date.available2007-09-12T03:51:17Z-
dc.date.issued1997en_HK
dc.identifier.citationOncogene, 1997, v. 14 n. 19, p. 2355-2365en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44317-
dc.description.abstractCytogenetic analyses has revealed deletions and/or rearrangments at several chromosomal positions in approximately half of uterine leiomyomas. The most frequent genetic alteration, deletion of 7q22, was found in approximately 35% of studied cases with cytogenetic abnormalities (128/366 = 35%). The same chromosomal band was also found to be deleted in a fraction of acute myeloid leukemias and myelodysplastic syndromes. The frequent deletion of 7q22 in some tumors suggest that a tumor suppressor gene may be located in this region. The human Cut-like homeobox gene, CUTL1, is one of the genes localized to 7q22 and it was shown previously to encode a transcriptional repressor that down-modulates the expression of c-Myc. Activation of the c-Myc oncogenic potential has been shown in many cancers to result from alterations in one or the other of its several mechanisms of regulation. These observations led us to hypothesize that CUTL1 could act as a tumor suppressor gene. In the present study, we have identified polymorphic markers within and directly adjacent to CUTL1 at 7q22 and demonstrated that these markers are present in a commonly deleted region in seven out of 50 uterine leiomyomas samples examined. Furthermore, Northern blot analysis revealed that CUTL1 mRNA levels were reduced in eight tumors out of 13. These results suggest that CUTL1 may act as a tumor suppressor gene whose inactivation could be of pathological importance in the etiology of uterine leiomyomas.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectChromosome 7q22en_HK
dc.subjectCUTL1en_HK
dc.subjectHuman Cut homeobox geneen_HK
dc.subjectLoss of heterozygosityen_HK
dc.subjectTumor suppressor geneen_HK
dc.subjectUterine leiomyomaen_HK
dc.subject.meshUterine leiomyomaen_HK
dc.subject.meshChromosome 7q22en_HK
dc.subject.meshTumor suppressor geneen_HK
dc.subject.meshCutl1en_HK
dc.subject.meshHuman cut homeobox geneen_HK
dc.titleLoss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=14&issue=19&spage=2355&epage= 2365&date=1997&atitle=Loss+of+heterozygosity+and+reduced+expression+of+the+CUTL1+gene+in+uterine+leiomyomasen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1038/sj.onc.1201076-
dc.identifier.pmid9178912-
dc.identifier.scopuseid_2-s2.0-0031001030en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031001030&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue19en_HK
dc.identifier.spage2355en_HK
dc.identifier.epage2365en_HK
dc.identifier.isiWOS:A1997WY88300013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZeng, WR=7203023762en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridKoutsilieris, M=7005149144en_HK
dc.identifier.scopusauthoridHuizenga, JJ=7005960086en_HK
dc.identifier.scopusauthoridFilteau, F=6505988256en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridNepveu, A=7005134365en_HK

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