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Article: Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome

TitleLinkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc.
Citation
American Journal of Medical Genetics, 1997, v. 74 n. 1, p. 58-61 How to Cite?
AbstractA defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D5 receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for linkage to the dopamine D5 receptor gene using a microsatellite polymorphism located in the same cosmid clone. Using an autosomal dominant model with reduced penetrance, we were able to exclude linkage in four of the five families for the TS and chronic multiple tics (CMT) phenotype. Also, no evidence for linkage was found using nonparametric methods in all five families.
Persistent Identifierhttp://hdl.handle.net/10722/44313
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBarr, CLen_HK
dc.contributor.authorWigg, KGen_HK
dc.contributor.authorZovko, Een_HK
dc.contributor.authorSandor, Pen_HK
dc.contributor.authorTsui, L-Cen_HK
dc.date.accessioned2007-09-12T03:51:13Z-
dc.date.available2007-09-12T03:51:13Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal of Medical Genetics, 1997, v. 74 n. 1, p. 58-61en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44313-
dc.description.abstractA defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D5 receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for linkage to the dopamine D5 receptor gene using a microsatellite polymorphism located in the same cosmid clone. Using an autosomal dominant model with reduced penetrance, we were able to exclude linkage in four of the five families for the TS and chronic multiple tics (CMT) phenotype. Also, no evidence for linkage was found using nonparametric methods in all five families.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics-
dc.subject.meshGilles de la tourette syndromeen_HK
dc.subject.meshGeneticsen_HK
dc.subject.meshDopamine d5 receptoren_HK
dc.subject.meshTourette syndrome - genetics - metabolismen_HK
dc.subject.meshPedigreeen_HK
dc.titleLinkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=74&issue=1&spage=58&epage=61&date=1997&atitle=Linkage+study+of+the+dopamine+D5+receptor+gene+and+Gilles+de+la+Tourette+syndromeen_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1002/(SICI)1096-8628(19970221)74:1<58::AID-AJMG13>3.0.CO;2-Qen_HK
dc.identifier.pmid9034008-
dc.identifier.isiWOS:A1997WG27300013-

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