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Article: Genomic organization and FISH mapping of human Pmel 17, the putative silver locus

TitleGenomic organization and FISH mapping of human Pmel 17, the putative silver locus
Authors
KeywordsChromosomal location
Chromosome 12 q12-q13
cis-Transcription elements
FISH mapping
Human Pmel 17 gene
Issue Date1996
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PCR
Citation
Pigment Cell Research, 1996, v. 9 n. 1, p. 42-48 How to Cite?
AbstractThe Pmel 17 gene is expressed preferentially in pigment cells. It has been mapped to human chromosome 12 pter-q21 and mouse chromosome 10, near the silver locus. The Pmel 17 gene contains an insertional mutation at its carboxyl terminus in the silver mouse, suggesting that the silver locus might correspond to the gene. In the current studies, we have isolated and characterized human Pmel 17 genomic clones and employed FISH mapping for a precise localization of this gene in the human chromosome. The FISH mapping placed the Pmel 17 gene at human chromosome 12 q12-q13. The human gene consists of nine exons and eight introns, and the entire coding region of the gene spans approximately 7.9 kb of the human chromosome 12. The putative functional domains, such as the signal sequence, histidine-rich, 26-amino acid repeats, cysteine-rich, transmembrane and cytoplasmic domains, were encoded by separate exons. Cis-transcription elements such as a TATA, a CAT and other potential elements for pigment cell-specific gene expression were found within 1100 base pairs of the 5′ flanking region.
Persistent Identifierhttp://hdl.handle.net/10722/44310
ISSN
2007 Impact Factor: 4.288
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKim, KKen_HK
dc.contributor.authorYoun, BSen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorLee, ZHen_HK
dc.contributor.authorPickard, RTen_HK
dc.contributor.authorKwon, BSen_HK
dc.date.accessioned2007-09-12T03:51:09Z-
dc.date.available2007-09-12T03:51:09Z-
dc.date.issued1996en_HK
dc.identifier.citationPigment Cell Research, 1996, v. 9 n. 1, p. 42-48en_HK
dc.identifier.issn0893-5785en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44310-
dc.description.abstractThe Pmel 17 gene is expressed preferentially in pigment cells. It has been mapped to human chromosome 12 pter-q21 and mouse chromosome 10, near the silver locus. The Pmel 17 gene contains an insertional mutation at its carboxyl terminus in the silver mouse, suggesting that the silver locus might correspond to the gene. In the current studies, we have isolated and characterized human Pmel 17 genomic clones and employed FISH mapping for a precise localization of this gene in the human chromosome. The FISH mapping placed the Pmel 17 gene at human chromosome 12 q12-q13. The human gene consists of nine exons and eight introns, and the entire coding region of the gene spans approximately 7.9 kb of the human chromosome 12. The putative functional domains, such as the signal sequence, histidine-rich, 26-amino acid repeats, cysteine-rich, transmembrane and cytoplasmic domains, were encoded by separate exons. Cis-transcription elements such as a TATA, a CAT and other potential elements for pigment cell-specific gene expression were found within 1100 base pairs of the 5′ flanking region.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PCRen_HK
dc.relation.ispartofPigment Cell Researchen_HK
dc.rightsFor full bibliographic citation, please refer to the version available at www.blackwell-synergy.comen_HK
dc.subjectChromosomal locationen_HK
dc.subjectChromosome 12 q12-q13en_HK
dc.subjectcis-Transcription elementsen_HK
dc.subjectFISH mappingen_HK
dc.subjectHuman Pmel 17 geneen_HK
dc.subject.meshChromosomes, human, pair 12en_HK
dc.subject.meshIn situ hybridization, fluorescenceen_HK
dc.subject.meshProteins - geneticsen_HK
dc.subject.meshAmino acid sequenceen_HK
dc.subject.meshMolecular sequence dataen_HK
dc.titleGenomic organization and FISH mapping of human Pmel 17, the putative silver locusen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1111/j.1600-0749.1996.tb00085.x-
dc.identifier.pmid8739560-
dc.identifier.scopuseid_2-s2.0-0030078608en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030078608&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue1en_HK
dc.identifier.spage42en_HK
dc.identifier.epage48en_HK
dc.identifier.isiWOS:A1996UH04000008-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridKim, KK=16180902100en_HK
dc.identifier.scopusauthoridYoun, BS=7005009217en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridShi, XM=37043617300en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridLee, ZH=24329591300en_HK
dc.identifier.scopusauthoridPickard, RT=7007115190en_HK
dc.identifier.scopusauthoridKwon, BS=26642910400en_HK

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