File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: A possible contributor to the holoprosencephaly 3 phenotype

TitleChromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: A possible contributor to the holoprosencephaly 3 phenotype
Authors
Issue Date1996
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1996, v. 37 n. 3, p. 345-353 How to Cite?
AbstractThe neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) have been shown to act on a wide range of tissue and cell types, both in the central nervous system and in the periphery. Two distinct receptors for VIP, the VIP receptor type 1 (VIPR1) and the VIP receptor type 2 (VIPR2), have recently been cloned, each of which binds PACAP and VIP with equal affinity. We report here the chromosomal mapping of the human and mouse VIPR2 genes by fluorescence in situ hybridization. The VIPR2 gene maps to the human chromosomal region 7q36.3 and to the F2 region of mouse chromosome 12. Our localization of the human gene places it in the region where the locus for the craniofacial defect holoprosencephaly type 3 (HPE3) maps. Further mapping experiments, carried out on cell lines derived from patients with HPE or HPE microforms and associated 7q deletions, have led us to redefine the distal extent of the HPE3 minimal critical region, originally characterized by Gurrieri et al. (1993, Nature Genet. 3: 247-251.) The VIPR2 gene lies within this new HPE3 minimal critical region. Our results suggest that deletion of the VIPR2 gene is not the sole factor responsible for the HPE3 phenotype. However, it is possible that monosomy at the VIPR2 locus may contribute to the phenotype observed in many cases of HPE3.
Persistent Identifierhttp://hdl.handle.net/10722/44307
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMackay, Men_HK
dc.contributor.authorFantes, Jen_HK
dc.contributor.authorScherer, Sen_HK
dc.contributor.authorBoyle, Sen_HK
dc.contributor.authorWest, Ken_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBelloni, Een_HK
dc.contributor.authorLutz, Een_HK
dc.contributor.authorVan Heyningen, Ven_HK
dc.contributor.authorHarmar, AJen_HK
dc.date.accessioned2007-09-12T03:51:06Z-
dc.date.available2007-09-12T03:51:06Z-
dc.date.issued1996en_HK
dc.identifier.citationGenomics, 1996, v. 37 n. 3, p. 345-353en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44307-
dc.description.abstractThe neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) have been shown to act on a wide range of tissue and cell types, both in the central nervous system and in the periphery. Two distinct receptors for VIP, the VIP receptor type 1 (VIPR1) and the VIP receptor type 2 (VIPR2), have recently been cloned, each of which binds PACAP and VIP with equal affinity. We report here the chromosomal mapping of the human and mouse VIPR2 genes by fluorescence in situ hybridization. The VIPR2 gene maps to the human chromosomal region 7q36.3 and to the F2 region of mouse chromosome 12. Our localization of the human gene places it in the region where the locus for the craniofacial defect holoprosencephaly type 3 (HPE3) maps. Further mapping experiments, carried out on cell lines derived from patients with HPE or HPE microforms and associated 7q deletions, have led us to redefine the distal extent of the HPE3 minimal critical region, originally characterized by Gurrieri et al. (1993, Nature Genet. 3: 247-251.) The VIPR2 gene lies within this new HPE3 minimal critical region. Our results suggest that deletion of the VIPR2 gene is not the sole factor responsible for the HPE3 phenotype. However, it is possible that monosomy at the VIPR2 locus may contribute to the phenotype observed in many cases of HPE3.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshChromosome mappingen_HK
dc.subject.meshChromosomes, human, pair 7 - geneticsen_HK
dc.subject.meshHoloprosencephaly - classification - genetics - pathologyen_HK
dc.subject.meshMice - geneticsen_HK
dc.subject.meshReceptors, vasoactive intestinal peptide - geneticsen_HK
dc.titleChromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: A possible contributor to the holoprosencephaly 3 phenotypeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=37&issue=3&spage=345&epage=353&date=1996&atitle=Chromosome+localization+in+mouse+and+human+of+the+vasoactive+intestinal+peptide+receptor+type+2+gene:+A+possible+contributor+to+the+holoprosencephaly+3+phenotypeen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1996.0569-
dc.identifier.pmid8938447-
dc.identifier.scopuseid_2-s2.0-0030298335en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030298335&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue3en_HK
dc.identifier.spage345en_HK
dc.identifier.epage353en_HK
dc.identifier.isiWOS:A1996VU07500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMackay, M=7103172844en_HK
dc.identifier.scopusauthoridFantes, J=7004280423en_HK
dc.identifier.scopusauthoridScherer, S=35374654500en_HK
dc.identifier.scopusauthoridBoyle, S=7005772146en_HK
dc.identifier.scopusauthoridWest, K=7401596836en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBelloni, E=7003332359en_HK
dc.identifier.scopusauthoridLutz, E=7103315089en_HK
dc.identifier.scopusauthoridVan Heyningen, V=7006570141en_HK
dc.identifier.scopusauthoridHarmar, AJ=7005232816en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats