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Article: Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET

TitleDetailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET
Authors
KeywordsBreast cancer
Chromosome 7q31
Loss of heterozygosity
MET receptor tyrosine kinase
Tumor suppressor gene
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1996, v. 13 n. 9, p. 2001-2008 How to Cite?
AbstractIn breast cancer, loss of heterozygosity (LOH) has been described on the long arm of chromosome 7 at band q31, suggesting the presence of a tumor suppressor gene in this region. To define the deleted region, we analysed 73 cases of breast cancer and matched normal DNAs with 17 polymorphic markers. A minimal area of LOH was identified as the chromosomal interval flanked by markers D7S687 and metH, spanning a segment of 2 Mb on chromosome 7q31. Of the 73 breast cancer patients studied, all were informative for at least one marker in this region and nine patients showed LOH at one or more loci (12.3%). To define the physical size of the deletion and to ensure the correct interpretation of the LOH deletion studies, we redefined the physical map of markers within this region of 7q31. We present a new physical order for markers at 7q31. More significantly, we have mapped the minimum deletion of 7q31 in the breast cancers studied to date to a physical distance of 1000 kb, contained on a single YAC clone, which includes the MET receptor tyrosine kinase but no other known genes.
Persistent Identifierhttp://hdl.handle.net/10722/44306
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, JCen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorTougas, Len_HK
dc.contributor.authorTraverso, Gen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorAndrulis, ILen_HK
dc.contributor.authorJothy, Sen_HK
dc.contributor.authorPark, Men_HK
dc.date.accessioned2007-09-12T03:51:04Z-
dc.date.available2007-09-12T03:51:04Z-
dc.date.issued1996en_HK
dc.identifier.citationOncogene, 1996, v. 13 n. 9, p. 2001-2008en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44306-
dc.description.abstractIn breast cancer, loss of heterozygosity (LOH) has been described on the long arm of chromosome 7 at band q31, suggesting the presence of a tumor suppressor gene in this region. To define the deleted region, we analysed 73 cases of breast cancer and matched normal DNAs with 17 polymorphic markers. A minimal area of LOH was identified as the chromosomal interval flanked by markers D7S687 and metH, spanning a segment of 2 Mb on chromosome 7q31. Of the 73 breast cancer patients studied, all were informative for at least one marker in this region and nine patients showed LOH at one or more loci (12.3%). To define the physical size of the deletion and to ensure the correct interpretation of the LOH deletion studies, we redefined the physical map of markers within this region of 7q31. We present a new physical order for markers at 7q31. More significantly, we have mapped the minimum deletion of 7q31 in the breast cancers studied to date to a physical distance of 1000 kb, contained on a single YAC clone, which includes the MET receptor tyrosine kinase but no other known genes.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectBreast canceren_HK
dc.subjectChromosome 7q31en_HK
dc.subjectLoss of heterozygosityen_HK
dc.subjectMET receptor tyrosine kinaseen_HK
dc.subjectTumor suppressor geneen_HK
dc.subject.meshBreast neoplasms - geneticsen_HK
dc.subject.meshChromosome mapping - methodsen_HK
dc.subject.meshChromosomes, human, pair 7en_HK
dc.subject.meshGenes, tumor suppressoren_HK
dc.subject.meshReceptor protein-tyrosine kinases - biosynthesis - geneticsen_HK
dc.titleDetailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of METen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.pmid8934547-
dc.identifier.scopuseid_2-s2.0-0029963491en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029963491&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2001en_HK
dc.identifier.epage2008en_HK
dc.identifier.isiWOS:A1996VR79500020-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, JC=7501721585en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridTougas, L=6507694103en_HK
dc.identifier.scopusauthoridTraverso, G=7006918319en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridAndrulis, IL=7005655442en_HK
dc.identifier.scopusauthoridJothy, S=7005657762en_HK
dc.identifier.scopusauthoridPark, M=7404490591en_HK

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