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Article: Molecular definition of a narrow interval at 7q22.1 associated with myelodysplasia

TitleMolecular definition of a narrow interval at 7q22.1 associated with myelodysplasia
Authors
Issue Date1996
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 1996, v. 87 n. 9, p. 3579-3586 How to Cite?
AbstractChromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study two cosmid DNA probes that mapped to 7q22.1 and were known to be separated by approximately 500 kb were identified to flank the proximal inversion breakpoint in a patient carrying a constitutional inversion (7q22.1-34) associated with MDS. A yeast artificial chromosome (YAC) clone that encompassed the two cosmids was identified and shown to span the breakpoint. Fluorescence in situ hybridization was then used to analyze six additional patients with myelodysplasia and chromosomal rearrangements of the 7q22 region (three patients had translocations and three carried deletions). The breakpoint in one of the patients was found to be contained within the same YAC clone that spanned the inversion breakpoint. Moreover, this same interval was determined to be absent in all three patients with chromosomal deletions. These results suggest that this segment of DNA on chromosome 7q22.1 may contain specific gene(s) that have a significant role in myeloid malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/44298
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
Other Identifiers
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJohnson, EJen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorOsborne, Len_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorOscier, Den_HK
dc.contributor.authorMould, Sen_HK
dc.contributor.authorCotter, FEen_HK
dc.date.accessioned2007-09-12T03:50:53Z-
dc.date.available2007-09-12T03:50:53Z-
dc.date.issued1996en_HK
dc.identifierhttp://bloodjournal.hematologylibrary.org/cgi/reprint/87/9/3579.pdfen_HK
dc.identifier.citationBlood, 1996, v. 87 n. 9, p. 3579-3586en_HK
dc.identifier.issn0006-4971en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44298-
dc.description.abstractChromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study two cosmid DNA probes that mapped to 7q22.1 and were known to be separated by approximately 500 kb were identified to flank the proximal inversion breakpoint in a patient carrying a constitutional inversion (7q22.1-34) associated with MDS. A yeast artificial chromosome (YAC) clone that encompassed the two cosmids was identified and shown to span the breakpoint. Fluorescence in situ hybridization was then used to analyze six additional patients with myelodysplasia and chromosomal rearrangements of the 7q22 region (three patients had translocations and three carried deletions). The breakpoint in one of the patients was found to be contained within the same YAC clone that spanned the inversion breakpoint. Moreover, this same interval was determined to be absent in all three patients with chromosomal deletions. These results suggest that this segment of DNA on chromosome 7q22.1 may contain specific gene(s) that have a significant role in myeloid malignancies.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_HK
dc.relation.ispartofBlooden_HK
dc.subject.meshChromosome aberrationsen_HK
dc.subject.meshChromosome aberrationsen_HK
dc.subject.meshChromosomes, human, pair 7en_HK
dc.subject.meshMyelodysplastic syndromes - geneticsen_HK
dc.subject.meshKaryotypingen_HK
dc.titleMolecular definition of a narrow interval at 7q22.1 associated with myelodysplasiaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.pmid8611680-
dc.identifier.scopuseid_2-s2.0-0029874494en_HK
dc.identifier.volume87en_HK
dc.identifier.issue9en_HK
dc.identifier.spage3579en_HK
dc.identifier.epage3586en_HK
dc.identifier.isiWOS:A1996UH14200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJohnson, EJ=7404681321en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridOsborne, L=35369973100en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridOscier, D=7005408586en_HK
dc.identifier.scopusauthoridMould, S=6603176921en_HK
dc.identifier.scopusauthoridCotter, FE=7006119322en_HK

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