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Article: No Evidence for a Major Gene Effect of the Dopamine D4 Receptor Gene in the Susceptibility to Gilles de la Tourette Syndrome in Five Canadian Families

TitleNo Evidence for a Major Gene Effect of the Dopamine D4 Receptor Gene in the Susceptibility to Gilles de la Tourette Syndrome in Five Canadian Families
Authors
KeywordsDopamine D4 receptor
Genetics
Gilles de la Tourette Syndrome
Issue Date1996
PublisherJohn Wiley & Sons, Inc.
Citation
American Journal Of Medical Genetics - Seminars In Medical Genetics, 1996, v. 67 n. 3, p. 301-305 How to Cite?
AbstractGilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics affecting approximately 1/10,000 females and 1/2000 males. Because of the success of neuroleptics and other agents interacting with the dopaminergic system in the suppression of tics, a defect in the dopamine system has been hypothesized in the etiology of TS. In this paper we test the hypothesis that the dopamine D4 receptor (DRD4) is linked to the genetic susceptibility to TS in five families. We tested three polymorphisms in the DRD4 gene and a polymorphism in the closely linked locus, tyrosine hydroxylase (TH). We found no evidence for linkage of DRD4 or TH to TS using an autosomal dominant model with reduced penetrance or using non-parametric methods. The presence of a mutation that results in a truncated non-functional D4 receptor protein was also tested for, but was not observed in these families. © 1996 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/44294
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarr, CLen_HK
dc.contributor.authorWigg, KGen_HK
dc.contributor.authorZovko, Een_HK
dc.contributor.authorSandor, Pen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:50:49Z-
dc.date.available2007-09-12T03:50:49Z-
dc.date.issued1996en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Seminars In Medical Genetics, 1996, v. 67 n. 3, p. 301-305en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44294-
dc.description.abstractGilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics affecting approximately 1/10,000 females and 1/2000 males. Because of the success of neuroleptics and other agents interacting with the dopaminergic system in the suppression of tics, a defect in the dopamine system has been hypothesized in the etiology of TS. In this paper we test the hypothesis that the dopamine D4 receptor (DRD4) is linked to the genetic susceptibility to TS in five families. We tested three polymorphisms in the DRD4 gene and a polymorphism in the closely linked locus, tyrosine hydroxylase (TH). We found no evidence for linkage of DRD4 or TH to TS using an autosomal dominant model with reduced penetrance or using non-parametric methods. The presence of a mutation that results in a truncated non-functional D4 receptor protein was also tested for, but was not observed in these families. © 1996 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Seminars in Medical Geneticsen_HK
dc.subjectDopamine D4 receptoren_HK
dc.subjectGeneticsen_HK
dc.subjectGilles de la Tourette Syndromeen_HK
dc.subject.meshGilles de la tourette syndromeen_HK
dc.subject.meshGeneticsen_HK
dc.subject.meshReceptors, dopamine d2 - geneticsen_HK
dc.subject.meshReceptors, dopamine d4en_HK
dc.subject.meshTyrosine 3-monooxygenase - geneticsen_HK
dc.titleNo Evidence for a Major Gene Effect of the Dopamine D4 Receptor Gene in the Susceptibility to Gilles de la Tourette Syndrome in Five Canadian Familiesen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1002/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO;2-P-
dc.identifier.pmid8725747-
dc.identifier.scopuseid_2-s2.0-0029931471en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029931471&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue3en_HK
dc.identifier.spage301en_HK
dc.identifier.epage305en_HK
dc.identifier.isiWOS:A1996UN62600006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBarr, CL=35447356300en_HK
dc.identifier.scopusauthoridWigg, KG=6602896419en_HK
dc.identifier.scopusauthoridZovko, E=6507130837en_HK
dc.identifier.scopusauthoridSandor, P=7006004292en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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