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Article: Fine mapping of the human and mouse genes for the type i procollagen COOH-terminal proteinase enhancer protein

TitleFine mapping of the human and mouse genes for the type i procollagen COOH-terminal proteinase enhancer protein
Authors
Issue Date1996
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1996, v. 31 n. 2, p. 253-256 How to Cite?
AbstractThe human gene (PCOLCE) for the C-proteinase enhancer, a glycoprotein that enhances the enzymatic activity that cleaves the type I procollagen C-propeptide, was previously mapped to the same cytogenetic region (7q21.3-q22) as COL1A2, the type I collagen proα2 chain gene. The apparent proximity of these two genes, whose products interact, might have reflected some mechanism for coregulation of expression. We have employed somatic cell hybrids, cosmid contigs, and interspecific backcross mice to investigate further the apparent proximity of the two genes. Our data show that PCOLCE and COL1A2 are separated by at least 6 Mb on human chromosome 7q and that Pcolce and Col1a2 are located on two separate chromosomes in mouse. These data also indicate that PCOLCE is located within a 10-to 15-cM region of conserved synteny between human chromosome 7 and mouse chromosome 5. © 1996 Academic Press, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/44290
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTakahara, Ken_HK
dc.contributor.authorOsborne, Len_HK
dc.contributor.authorElliott, RWen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorGreenspan, DSen_HK
dc.date.accessioned2007-09-12T03:50:45Z-
dc.date.available2007-09-12T03:50:45Z-
dc.date.issued1996en_HK
dc.identifier.citationGenomics, 1996, v. 31 n. 2, p. 253-256en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44290-
dc.description.abstractThe human gene (PCOLCE) for the C-proteinase enhancer, a glycoprotein that enhances the enzymatic activity that cleaves the type I procollagen C-propeptide, was previously mapped to the same cytogenetic region (7q21.3-q22) as COL1A2, the type I collagen proα2 chain gene. The apparent proximity of these two genes, whose products interact, might have reflected some mechanism for coregulation of expression. We have employed somatic cell hybrids, cosmid contigs, and interspecific backcross mice to investigate further the apparent proximity of the two genes. Our data show that PCOLCE and COL1A2 are separated by at least 6 Mb on human chromosome 7q and that Pcolce and Col1a2 are located on two separate chromosomes in mouse. These data also indicate that PCOLCE is located within a 10-to 15-cM region of conserved synteny between human chromosome 7 and mouse chromosome 5. © 1996 Academic Press, Inc.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshBone morphogenetic proteinsen_HK
dc.subject.meshChromosomes, human, pair 7 - geneticsen_HK
dc.subject.meshMetalloendopeptidases - geneticsen_HK
dc.subject.meshMice, inbred c57blen_HK
dc.subject.meshDna primersen_HK
dc.titleFine mapping of the human and mouse genes for the type i procollagen COOH-terminal proteinase enhancer proteinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=31&issue=2&spage=253&epage=256&date=1996&atitle=Fine+mapping+of+the+human+and+mouse+genes+for+the+type+I+procollagen+COOH-terminal+protease+enhancer+proteinen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1996.0043en_HK
dc.identifier.pmid8824813-
dc.identifier.scopuseid_2-s2.0-0030041410en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030041410&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue2en_HK
dc.identifier.spage253en_HK
dc.identifier.epage256en_HK
dc.identifier.isiWOS:A1996TT13800019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTakahara, K=7005296643en_HK
dc.identifier.scopusauthoridOsborne, L=35369973100en_HK
dc.identifier.scopusauthoridElliott, RW=7402640055en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridGreenspan, DS=7102791607en_HK

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