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Article: Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31

TitleDifferential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31
Authors
KeywordsAcute lymphoblastic leukemia
Acute myelogenous leukemia
Basic helix-loop-helix protein
Chromosome 1
Chronic myelogenous leukemia
G0S8
Issue Date1995
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leu
Citation
Leukemia, 1995, v. 9 n. 8, p. 1291-1298 How to Cite?
AbstractA basic helix-loop-helix phosphoprotein gene, G0S8, was recently isolated by differential screening of cDNA from human blood mononuclear cells stimulated with a T cell mitogen and cycloheximide. In this study, G0S8 expression was examined in normal and malignant hematopoietic cells by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). G0S8 expression was observed in most fresh samples of acute myelogenous leukemia (AML) (28/30) and most cases of adult acute lymphoblastic leukemia (ALL) (9/11) regardless of clinical classification. G0S8 mRNA was also detected in all cases tested of chronic myelogenous leukemia (CML) in blast crisis. However, G0S8 expression was not detected in CML patients in chronic phase, nor in normal bone marrow or other hematopoietic cells. G0S8 has been mapped using fluorescence in site hybridization (FISH) to human chromosome 1q31, the same site reported for the B cell homolog BL34/1R20 and within a region implicated in the development of hematological malignancies. The consistent observation of G0S8 mRNA in patient samples of acute leukemia suggests that G0S8 expression may either play a role in leukemogenesis or represent a common consequence of dysregulated growth.
Persistent Identifierhttp://hdl.handle.net/10722/44288
ISSN
2015 Impact Factor: 12.104
2015 SCImago Journal Rankings: 5.142
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorWu, HKen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorForsdyke, DRen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorMak, TWen_HK
dc.contributor.authorMinden, MDen_HK
dc.contributor.authorSiderovski, DPen_HK
dc.date.accessioned2007-09-12T03:50:42Z-
dc.date.available2007-09-12T03:50:42Z-
dc.date.issued1995en_HK
dc.identifier.citationLeukemia, 1995, v. 9 n. 8, p. 1291-1298en_HK
dc.identifier.issn0887-6924en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44288-
dc.description.abstractA basic helix-loop-helix phosphoprotein gene, G0S8, was recently isolated by differential screening of cDNA from human blood mononuclear cells stimulated with a T cell mitogen and cycloheximide. In this study, G0S8 expression was examined in normal and malignant hematopoietic cells by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). G0S8 expression was observed in most fresh samples of acute myelogenous leukemia (AML) (28/30) and most cases of adult acute lymphoblastic leukemia (ALL) (9/11) regardless of clinical classification. G0S8 mRNA was also detected in all cases tested of chronic myelogenous leukemia (CML) in blast crisis. However, G0S8 expression was not detected in CML patients in chronic phase, nor in normal bone marrow or other hematopoietic cells. G0S8 has been mapped using fluorescence in site hybridization (FISH) to human chromosome 1q31, the same site reported for the B cell homolog BL34/1R20 and within a region implicated in the development of hematological malignancies. The consistent observation of G0S8 mRNA in patient samples of acute leukemia suggests that G0S8 expression may either play a role in leukemogenesis or represent a common consequence of dysregulated growth.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leuen_HK
dc.relation.ispartofLeukemiaen_HK
dc.subjectAcute lymphoblastic leukemiaen_HK
dc.subjectAcute myelogenous leukemiaen_HK
dc.subjectBasic helix-loop-helix proteinen_HK
dc.subjectChromosome 1en_HK
dc.subjectChronic myelogenous leukemiaen_HK
dc.subjectG0S8en_HK
dc.subject.meshDna-binding proteins - geneticsen_HK
dc.subject.meshGene expression regulation, neoplasticen_HK
dc.subject.meshHelix-loop-helix motifsen_HK
dc.subject.meshRgs proteinsen_HK
dc.subject.meshPhosphoproteins - geneticsen_HK
dc.titleDifferential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31en_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.pmid7643615en_HK
dc.identifier.scopuseid_2-s2.0-0029115312en_HK
dc.identifier.volume9en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1291en_HK
dc.identifier.epage1298en_HK
dc.identifier.isiWOS:A1995RR88900001-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.erratumeid:eid_2-s2.0-0029593266-
dc.identifier.scopusauthoridWu, HK=24777496100en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridShi, XM=7402953863en_HK
dc.identifier.scopusauthoridForsdyke, DR=7005066557en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridMak, TW=7401931099en_HK
dc.identifier.scopusauthoridMinden, MD=7006060361en_HK
dc.identifier.scopusauthoridSiderovski, DP=7004949965en_HK

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