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Article: Isolation of three novel human genes encoding G protein-coupled receptors

TitleIsolation of three novel human genes encoding G protein-coupled receptors
Authors
Issue Date1995
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/dna
Citation
Dna And Cell Biology, 1995, v. 14 n. 1, p. 25-35 How to Cite?
AbstractWe have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane regions) with the human orphan receptor GPR3 and was localized to chromosome 6 (q21-q22.1). Northern blot analysis revealed that GPR6 transcripts were abundant in the human putamen and to a lesser extent in the frontal cortex, hippocampus, and hypothalamus. Gene GPR5 encoded a receptor that most closely resembled the orphan receptor RBS11 (48% in the transmembrane regions) and the MIP Iα/RANTES receptor (45% in the transmembrane regions) and was localized to chromosome 3 (p21.3-p21.1). Gene GPR4 shared identity (40% in the transmembrane regions) with the human platelet-activating factor receptor and was localized to chromosome 19 (q13.2-q13.3).
Persistent Identifierhttp://hdl.handle.net/10722/44284
ISSN
2015 Impact Factor: 2.574
2015 SCImago Journal Rankings: 0.810
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHeiber, Men_HK
dc.contributor.authorDocherty, JMen_HK
dc.contributor.authorShah, Gen_HK
dc.contributor.authorNguyen, Ten_HK
dc.contributor.authorCheng, Ren_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorMarchese, Aen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorShi, Xen_HK
dc.contributor.authorGeorge, SRen_HK
dc.contributor.authorO'Dowd, BFen_HK
dc.date.accessioned2007-09-12T03:50:37Z-
dc.date.available2007-09-12T03:50:37Z-
dc.date.issued1995en_HK
dc.identifier.citationDna And Cell Biology, 1995, v. 14 n. 1, p. 25-35en_HK
dc.identifier.issn1044-5498en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44284-
dc.description.abstractWe have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane regions) with the human orphan receptor GPR3 and was localized to chromosome 6 (q21-q22.1). Northern blot analysis revealed that GPR6 transcripts were abundant in the human putamen and to a lesser extent in the frontal cortex, hippocampus, and hypothalamus. Gene GPR5 encoded a receptor that most closely resembled the orphan receptor RBS11 (48% in the transmembrane regions) and the MIP Iα/RANTES receptor (45% in the transmembrane regions) and was localized to chromosome 3 (p21.3-p21.1). Gene GPR4 shared identity (40% in the transmembrane regions) with the human platelet-activating factor receptor and was localized to chromosome 19 (q13.2-q13.3).en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/dnaen_HK
dc.relation.ispartofDNA and Cell Biologyen_HK
dc.subject.meshGenes - geneticsen_HK
dc.subject.meshMembrane proteinsen_HK
dc.subject.meshReceptors, cell surface - chemistry - geneticsen_HK
dc.subject.meshReceptors, g-protein-coupleden_HK
dc.subject.meshSequence homology, amino aciden_HK
dc.titleIsolation of three novel human genes encoding G protein-coupled receptorsen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1089/dna.1995.14.25-
dc.identifier.pmid7832990-
dc.identifier.scopuseid_2-s2.0-0028978079en_HK
dc.identifier.volume14en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage35en_HK
dc.identifier.isiWOS:A1995QD52000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHeiber, M=6507950665en_HK
dc.identifier.scopusauthoridDocherty, JM=7102949746en_HK
dc.identifier.scopusauthoridShah, G=7202979761en_HK
dc.identifier.scopusauthoridNguyen, T=26667936100en_HK
dc.identifier.scopusauthoridCheng, R=7201955297en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridMarchese, A=7005075855en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridShi, X=7402953863en_HK
dc.identifier.scopusauthoridGeorge, SR=35429392100en_HK
dc.identifier.scopusauthoridO'Dowd, BF=7102778005en_HK

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