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Article: MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain

TitleMLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain
Authors
Issue Date1994
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1994, v. 9 n. 6, p. 1745-1750 How to Cite?
AbstractWe have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived from sequencing a 3.5 kb MLK-3 cDNA, encodes a protein of 847 amino acids with several interesting structural features. These include an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. This kinase shows homology with the mixed-lineage family of protein kinases (MLK) and shares the unusual leucine zipper-basic motif found in previously identified MLK kinases. By northern analysis, MLK-3 mRNA was detected in a wide variety of normal and transformed human cell lines and tissue specimens. The gene encoding MLK-3 has been mapped using fluorescence in situ hybridization to human chromosome 11 q13.1-13.3, a region frequently altered in human malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/44280
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLynn Ing, Yen_HK
dc.contributor.authorLeung, IWLen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorLassam, NJen_HK
dc.date.accessioned2007-09-12T03:50:32Z-
dc.date.available2007-09-12T03:50:32Z-
dc.date.issued1994en_HK
dc.identifier.citationOncogene, 1994, v. 9 n. 6, p. 1745-1750en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44280-
dc.description.abstractWe have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived from sequencing a 3.5 kb MLK-3 cDNA, encodes a protein of 847 amino acids with several interesting structural features. These include an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. This kinase shows homology with the mixed-lineage family of protein kinases (MLK) and shares the unusual leucine zipper-basic motif found in previously identified MLK kinases. By northern analysis, MLK-3 mRNA was detected in a wide variety of normal and transformed human cell lines and tissue specimens. The gene encoding MLK-3 has been mapped using fluorescence in situ hybridization to human chromosome 11 q13.1-13.3, a region frequently altered in human malignancies.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subject.meshLeucine zippersen_HK
dc.subject.meshProtein kinases - chemistry - geneticsen_HK
dc.subject.meshRna, messenger - analysisen_HK
dc.subject.meshChromosomes, human, pair 11en_HK
dc.subject.meshMolecular sequence dataen_HK
dc.titleMLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domainen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.pmid8183572en_HK
dc.identifier.scopuseid_2-s2.0-23444453486en_HK
dc.identifier.volume9en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1745en_HK
dc.identifier.epage1750en_HK
dc.identifier.isiWOS:A1994NL81500029-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLynn Ing, Y=6701750065en_HK
dc.identifier.scopusauthoridLeung, IWL=36913978400en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridLassam, NJ=7003743180en_HK

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