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Article: Mapping the midkine family of developmentally regulated signaling molecules

TitleMapping the midkine family of developmentally regulated signaling molecules
Authors
Issue Date1993
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/
Citation
Mammalian Genome, 1993, v. 4 n. 11, p. 632-638 How to Cite?
AbstractMidkine (Mdk) and heparin-binding neurotrophic factor (Hbnf)/pleiotrophin (Ptn) comprise the Midkine family of developmentally regulated signaling molecules. We have determined the chromosomal localization of these genes in the mouse by use of single-strand conformation polymorphisms (SSCPs), which facilitated the typing of Mdk and Hbnf alleles in recombinant inbred (RI) strains and interspecific backcrosses. Mapping was performed relative to other cloned genes, as well as simple sequence length polymorphisms (SSLPs) in the interspecific backcrosses. Mdk maps to mouse Chromosome (Chr) 2, linked to the Hoxd gene cluster. Hbnf maps to proximal mouse Chr 6, linked to the Cftr and Cpa genes. Comparative mapping of human MDK and HBNF employing species-specific polymerase chain reaction (PCR) primers and human monochromosomal somatic cell hybrids assigns MDK to human Chr 11 and HBNF to human Chr 7q32-qter.
Persistent Identifierhttp://hdl.handle.net/10722/44270
ISSN
2015 Impact Factor: 2.078
2015 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPeichel, CLen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBeier, DRen_HK
dc.contributor.authorVogt, TFen_HK
dc.date.accessioned2007-09-12T03:50:20Z-
dc.date.available2007-09-12T03:50:20Z-
dc.date.issued1993en_HK
dc.identifier.citationMammalian Genome, 1993, v. 4 n. 11, p. 632-638en_HK
dc.identifier.issn0938-8990en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44270-
dc.description.abstractMidkine (Mdk) and heparin-binding neurotrophic factor (Hbnf)/pleiotrophin (Ptn) comprise the Midkine family of developmentally regulated signaling molecules. We have determined the chromosomal localization of these genes in the mouse by use of single-strand conformation polymorphisms (SSCPs), which facilitated the typing of Mdk and Hbnf alleles in recombinant inbred (RI) strains and interspecific backcrosses. Mapping was performed relative to other cloned genes, as well as simple sequence length polymorphisms (SSLPs) in the interspecific backcrosses. Mdk maps to mouse Chromosome (Chr) 2, linked to the Hoxd gene cluster. Hbnf maps to proximal mouse Chr 6, linked to the Cftr and Cpa genes. Comparative mapping of human MDK and HBNF employing species-specific polymerase chain reaction (PCR) primers and human monochromosomal somatic cell hybrids assigns MDK to human Chr 11 and HBNF to human Chr 7q32-qter.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/en_HK
dc.relation.ispartofMammalian Genomeen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.subject.meshCarrier proteins - geneticsen_HK
dc.subject.meshChromosomes, human, pair 11en_HK
dc.subject.meshChromosomes, human, pair 7en_HK
dc.subject.meshCytokines - geneticsen_HK
dc.subject.meshGene expression regulationen_HK
dc.titleMapping the midkine family of developmentally regulated signaling moleculesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0938-8990&volume=4&issue=11&spage=632&epage=638&date=1993&atitle=Mapping+themidkine+family+of+developmentally+regulated+signaling+moleculesen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1007/BF00360899en_HK
dc.identifier.pmid8281012en_HK
dc.identifier.scopuseid_2-s2.0-0027688026en_HK
dc.identifier.volume4en_HK
dc.identifier.issue11en_HK
dc.identifier.spage632en_HK
dc.identifier.epage638en_HK
dc.identifier.isiWOS:A1993MF57400002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPeichel, CL=6602163057en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBeier, DR=7006462014en_HK
dc.identifier.scopusauthoridVogt, TF=16154720700en_HK

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