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Article: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

TitleA human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
Authors
Keywordsfluorescence in situ hybridization
G protein-coupled receptors
polymerase chain reaction
transmembrane
vasopressin
Issue Date1993
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 1993, v. 136 n. 1-2, p. 355-360 How to Cite?
AbstractWe report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.
Persistent Identifierhttp://hdl.handle.net/10722/44269
ISSN
2015 Impact Factor: 2.319
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorO'Dowd, BFen_HK
dc.contributor.authorHeiber, Men_HK
dc.contributor.authorChan, Aen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorKennedy, JLen_HK
dc.contributor.authorShi, Xen_HK
dc.contributor.authorPetronis, Aen_HK
dc.contributor.authorGeorge, SRen_HK
dc.contributor.authorNguyen, Ten_HK
dc.date.accessioned2007-09-12T03:50:18Z-
dc.date.available2007-09-12T03:50:18Z-
dc.date.issued1993en_HK
dc.identifier.citationGene, 1993, v. 136 n. 1-2, p. 355-360en_HK
dc.identifier.issn0378-1119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44269-
dc.description.abstractWe report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/geneen_HK
dc.relation.ispartofGeneen_HK
dc.subjectfluorescence in situ hybridizationen_HK
dc.subjectG protein-coupled receptorsen_HK
dc.subjectpolymerase chain reactionen_HK
dc.subjecttransmembraneen_HK
dc.subjectvasopressinen_HK
dc.subject.meshChromosomes, human, pair 11en_HK
dc.subject.meshIn situ hybridization, fluorescenceen_HK
dc.subject.meshReceptors, angiotensin - geneticsen_HK
dc.subject.meshSequence homology, amino aciden_HK
dc.subject.meshAmino acid sequenceen_HK
dc.titleA human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-1119&volume=136&issue=1-2&spage=355&epage=360&date=1993&atitle=A+human+gene+that+shows+identity+with+the+angiotensin+receptor+is+located+on+chromosome+11en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/0378-1119(93)90495-Oen_HK
dc.identifier.pmid8294032-
dc.identifier.scopuseid_2-s2.0-0027717002en_HK
dc.identifier.volume136en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage355en_HK
dc.identifier.epage360en_HK
dc.identifier.isiWOS:A1993MU76700055-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridO'Dowd, BF=7102778005en_HK
dc.identifier.scopusauthoridHeiber, M=6507950665en_HK
dc.identifier.scopusauthoridChan, A=7403168292en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridKennedy, JL=36012646700en_HK
dc.identifier.scopusauthoridShi, X=7402953863en_HK
dc.identifier.scopusauthoridPetronis, A=7003912209en_HK
dc.identifier.scopusauthoridGeorge, SR=35429392100en_HK
dc.identifier.scopusauthoridNguyen, T=26667936100en_HK

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