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Article: Refined mapping of the G(M2) activator protein (GM2A) locus to 5q31.3- q33.1, distal to the spinal muscular atrophy locus

TitleRefined mapping of the G(M2) activator protein (GM2A) locus to 5q31.3- q33.1, distal to the spinal muscular atrophy locus
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1993, v. 18 n. 2, p. 429-431 How to Cite?
AbstractThe G(M2) activator locus (GM2A) had previously been considered as a candidate gene for some forms of spinal muscular atrophy (SMA; mapped to 5q11.2-q13.3). It was eliminated as a possible candidate because PCR-based mapping failed to localize the gene to chromosome 5, as was previously reported using an ELISA-based methodology. However, we demonstrated that the PCR primers used preferentially amplified a processed pseudogene (GM2AP) that we mapped to chromosome 3 and that GM2A was located on chromosome 5. In this report, we reconsider the candidacy of GM2A by refining its localization on chromosome 5 using fluorescence in situ hybridization. We localize GM2A to 5q31.3-q33.1; thus, it is not a candidate gene for SMA.
Persistent Identifierhttp://hdl.handle.net/10722/44267
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorXie, Ben_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorMahuran, DJen_HK
dc.date.accessioned2007-09-12T03:50:16Z-
dc.date.available2007-09-12T03:50:16Z-
dc.date.issued1993en_HK
dc.identifier.citationGenomics, 1993, v. 18 n. 2, p. 429-431en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44267-
dc.description.abstractThe G(M2) activator locus (GM2A) had previously been considered as a candidate gene for some forms of spinal muscular atrophy (SMA; mapped to 5q11.2-q13.3). It was eliminated as a possible candidate because PCR-based mapping failed to localize the gene to chromosome 5, as was previously reported using an ELISA-based methodology. However, we demonstrated that the PCR primers used preferentially amplified a processed pseudogene (GM2AP) that we mapped to chromosome 3 and that GM2A was located on chromosome 5. In this report, we reconsider the candidacy of GM2A by refining its localization on chromosome 5 using fluorescence in situ hybridization. We localize GM2A to 5q31.3-q33.1; thus, it is not a candidate gene for SMA.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshCells, cultureden_HK
dc.subject.meshChromosomes, human, pair 5en_HK
dc.subject.meshDna primersen_HK
dc.subject.meshG(m2) activator proteinen_HK
dc.subject.meshG(m2) ganglioside - geneticsen_HK
dc.titleRefined mapping of the G(M2) activator protein (GM2A) locus to 5q31.3- q33.1, distal to the spinal muscular atrophy locusen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1993.1491en_HK
dc.identifier.pmid8288250-
dc.identifier.scopuseid_2-s2.0-0027330166en_HK
dc.identifier.volume18en_HK
dc.identifier.issue2en_HK
dc.identifier.spage429en_HK
dc.identifier.epage431en_HK
dc.identifier.isiWOS:A1993MG99300040-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridXie, B=7201872722en_HK
dc.identifier.scopusauthoridShi, XM=37043617300en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridMahuran, DJ=7004841730en_HK

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