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Article: Developmental regulation and cell type-specific expression of the murine γF-crystalline gene is mediated through a lens-specific element containing the γF-1 binding site

TitleDevelopmental regulation and cell type-specific expression of the murine γF-crystalline gene is mediated through a lens-specific element containing the γF-1 binding site
Authors
KeywordsCrystallin gene
Lens specificity
Transcriptional regulation
Transgenic mice
Issue Date1993
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Citation
Developmental Dynamics, 1993, v. 196 n. 2, p. 143-152 How to Cite?
AbstractThe mouse γF-crystallin gene, one of six differentially regulated members of the γ-crystallin gene family, is expressed exclusively in central nuclear fiber cells of the adult lens. The expression of this gene is controlled through regulatory elements contained in two upstream enhancers and the proximal promoter. Here we show that while the upstream enhancers and the proximal promoter could each direct gene expression in fiber cells formed at early stages of lens growth and development, cooperation between these elements is required to achieve expression in fiber cells formed at later stages. Evidence is provided that cooperative interaction between these elements modulates gene expression by increasing promoter strength. We also show that sequences within the proximal promoter region that bind lens cell nuclear factor γF-1 are sufficient to elicit gene expression in central nuclear fiber cells of the adult lens.
Persistent Identifierhttp://hdl.handle.net/10722/44260
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGoring, DRen_HK
dc.contributor.authorBryce, DMen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBreitman, MLen_HK
dc.contributor.authorLiu, Qen_HK
dc.date.accessioned2007-09-12T03:50:06Z-
dc.date.available2007-09-12T03:50:06Z-
dc.date.issued1993en_HK
dc.identifier.citationDevelopmental Dynamics, 1993, v. 196 n. 2, p. 143-152en_HK
dc.identifier.issn1058-8388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44260-
dc.description.abstractThe mouse γF-crystallin gene, one of six differentially regulated members of the γ-crystallin gene family, is expressed exclusively in central nuclear fiber cells of the adult lens. The expression of this gene is controlled through regulatory elements contained in two upstream enhancers and the proximal promoter. Here we show that while the upstream enhancers and the proximal promoter could each direct gene expression in fiber cells formed at early stages of lens growth and development, cooperation between these elements is required to achieve expression in fiber cells formed at later stages. Evidence is provided that cooperative interaction between these elements modulates gene expression by increasing promoter strength. We also show that sequences within the proximal promoter region that bind lens cell nuclear factor γF-1 are sufficient to elicit gene expression in central nuclear fiber cells of the adult lens.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417en_HK
dc.relation.ispartofDevelopmental Dynamicsen_HK
dc.subjectCrystallin geneen_HK
dc.subjectLens specificityen_HK
dc.subjectTranscriptional regulationen_HK
dc.subjectTransgenic miceen_HK
dc.subject.meshCrystallin geneen_HK
dc.subject.meshLens specificityen_HK
dc.subject.meshTranscriptional regulationen_HK
dc.subject.meshTransgenic miceen_HK
dc.subject.meshCrystallins - analysis - geneticsen_HK
dc.titleDevelopmental regulation and cell type-specific expression of the murine γF-crystalline gene is mediated through a lens-specific element containing the γF-1 binding siteen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/aja.1001960208en_HK
dc.identifier.pmid8364223-
dc.identifier.scopuseid_2-s2.0-0027269795en_HK
dc.identifier.volume196en_HK
dc.identifier.issue2en_HK
dc.identifier.spage143en_HK
dc.identifier.epage152en_HK
dc.identifier.isiWOS:A1993LL23900007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGoring, DR=7005468517en_HK
dc.identifier.scopusauthoridBryce, DM=7006138663en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK
dc.identifier.scopusauthoridLiu, Q=7406296355en_HK

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