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Article: Progressive and regressive fate of lens tumors correlates with subtle differences in transgene expression in γF-crystallin-SV40 T antigen transgenic mice

TitleProgressive and regressive fate of lens tumors correlates with subtle differences in transgene expression in γF-crystallin-SV40 T antigen transgenic mice
Authors
Issue Date1993
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1993, v. 8 n. 6, p. 1611-1620 How to Cite?
AbstractRegulatory elements of the mouse γF-crystallin gene were used to derive transgenic mice expressing SV40 large T antigen in terminally differentiating fiber cells of the ocular lens. The resulting γF-crystallin-T antigen mice developed either malignant or regressive lens tumors in a strain-dependent fashion. Developmental and RNA analyses revealed that in both 'tumor-progressing' and 'tumor-regressing' mouse strains expression of the transgene blocked morphological differentiation of lens fibers without appreciably affecting γ-crystallin gene expression, a marker of terminal lens fiber cell differentiation. Strain-dependent differences in tumorigenic outcome could be correlated with both subtle differences in transgene expression and the ability of tumor cells to escape from the normal confines of the lens. The results implicate the importance of cellular environment to malignant tumor development and provide insight into those features of normal lens ontogeny that may render the lens refractory to the development of spontaneous tumors.
Persistent Identifierhttp://hdl.handle.net/10722/44258
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBryce, DMen_HK
dc.contributor.authorLiu, Qen_HK
dc.contributor.authorKhoo, Wen_HK
dc.contributor.authorTsui, LTen_HK
dc.contributor.authorBreitman, MLen_HK
dc.date.accessioned2007-09-12T03:50:03Z-
dc.date.available2007-09-12T03:50:03Z-
dc.date.issued1993en_HK
dc.identifier.citationOncogene, 1993, v. 8 n. 6, p. 1611-1620en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44258-
dc.description.abstractRegulatory elements of the mouse γF-crystallin gene were used to derive transgenic mice expressing SV40 large T antigen in terminally differentiating fiber cells of the ocular lens. The resulting γF-crystallin-T antigen mice developed either malignant or regressive lens tumors in a strain-dependent fashion. Developmental and RNA analyses revealed that in both 'tumor-progressing' and 'tumor-regressing' mouse strains expression of the transgene blocked morphological differentiation of lens fibers without appreciably affecting γ-crystallin gene expression, a marker of terminal lens fiber cell differentiation. Strain-dependent differences in tumorigenic outcome could be correlated with both subtle differences in transgene expression and the ability of tumor cells to escape from the normal confines of the lens. The results implicate the importance of cellular environment to malignant tumor development and provide insight into those features of normal lens ontogeny that may render the lens refractory to the development of spontaneous tumors.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subject.meshAntigens, polyomavirus transforming - biosynthesis - geneticsen_HK
dc.subject.meshCrystallins - biosynthesis - geneticsen_HK
dc.subject.meshEye neoplasms - genetics - pathologyen_HK
dc.subject.meshLens diseases - genetics - pathologyen_HK
dc.subject.meshSimian virus 40 - geneticsen_HK
dc.titleProgressive and regressive fate of lens tumors correlates with subtle differences in transgene expression in γF-crystallin-SV40 T antigen transgenic miceen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LT: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LT=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.pmid8389033en_HK
dc.identifier.scopuseid_2-s2.0-0027280581en_HK
dc.identifier.volume8en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1611en_HK
dc.identifier.epage1620en_HK
dc.identifier.isiWOS:A1993LE06400025-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBryce, DM=7006138663en_HK
dc.identifier.scopusauthoridLiu, Q=7406296355en_HK
dc.identifier.scopusauthoridKhoo, W=6602677510en_HK
dc.identifier.scopusauthoridTsui, LT=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK

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